Navigation Links
Enzyme Beneficial to Alzheimer's Plays Darker Role in Other Dementia
Date:4/23/2008

Finding could mean changing animal models used for future research

WEDNESDAY, April 23 (HealthDay News) -- An enzyme shown to help suppress development of Alzheimer's disease appears to hasten progress of a related but far less common type of dementia, according to a new study.

The surprising findings, published in the April 22 online issue of The Journal of Clinical Investigation, are significant, because individuals with frontotemporal dementia with parkinsonism-17 -- a relatively rare hereditary form of dementia -- are often used as models for studying Alzheimer's disease.

Alzheimer's disease and frontotemporal dementia each develop as a result of too many tau proteins accumulating and causing tangled lesions in the brain's neurons. These knotted nerve cells eventually choke off the brain cells responsible for memory.

However, individuals with frontotemporal dementia have mutations in the gene, known as P301L, encoding tau. These mutations have not been found in individuals with Alzheimer's.

Researchers found in mouse models and human cells that boosting levels of the prolyl isomerase (Pin1) enzyme, previously shown to aid in "detangling" tau in Alzheimer's disease, helps break down the tau proteins. However, the same experiments on mice with the genetic mutations in the tau that cause frontotemporal dementia resulted in increased and accelerated tau protein tangling.

"First, we have established a proof of concept that boosting Pin1 activity may offer a new idea for preventing or even treating the tau pathology and neurodegeneration in Alzheimer's disease," senior author Kun Ping Lu, a scientist in the Division of Hematology/Oncology at Beth Israel Deaconess Medical Center, said in a prepared statement. "And, second, given that no tau mutation is found in Alzheimer's patients, this research suggests that it would be prudent to not use P301L tau as an Alzheimer's disease model, espec
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. Blood pressure enzyme can have tumor-sensing role
2. Enzyme complex could be key to new cancer treatments
3. Elevated liver enzymes associated with higher future mortality
4. Enzyme structure reveals new drug targets for cancer and other diseases
5. Genzyme Delivers Strong Fourth Quarter to Conclude Outstanding Year
6. AGI Dermatics Data Indicates 8 Oxo-Guanine Repair Enzyme OGG1 Encapsulated in Liposomes, Reduces MMP-1, Increases Collagen and Enhances DNA Repair
7. First look at an enzyme target for antibacterial and cancer drugs
8. Caught in the act: The dynamic dance of enzymes
9. McGill researchers link enzyme to breast cancer malignancy
10. Telomerase enzyme structure provides significant new target for anti-cancer therapies
11. Genzyme Receives FDA Response Letter on Synvisc-One(TM)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... Steven Reinberg HealthDay ... If you can,t balance on one leg for at least ... Japanese researchers suggest. Difficulty standing on one leg may ... which means the risk for more serious strokes is high, ... Stroke . "Individuals showing instability while standing on one ...
(Date:12/17/2014)... Myo Nwe is the co-author of a new weight loss ... of the Ace Medical Weight Loss Center in Rock Hill, ... at the industry of weight loss, and how several fad ... in television shows, however, she says the topic of obesity ... for basic laughs, which she believes impacts whether Americans view ...
(Date:12/17/2014)... This prestigious award is given annually ... outstanding and innovative contributions to the physical therapy ... practice physical therapy by the Private Practice Section ... behalf of Performance Physical Therapy, Michelle Collie PT, ... accepted the award at the Private Practice, APTA ...
(Date:12/17/2014)... 2014 A group of 127 scientists sent ... in reaction to a recent statement by the center that ... and derogated the efficacy of all brain exercises. , Signatories ... parts of the center’s statement critical of brain exercise companies ... also overstated its case, in a document it had entitled ...
(Date:12/17/2014)... No matter how far modern medicine ... the head louse parasite—a common childhood malady and a ... between six and twelve million individuals will suffer an ... treatment company comes to the rescue, providing an all-natural ... its track record of customer service, and effectiveness in ...
Breaking Medicine News(10 mins):Health News:Can You Balance on One Leg? You May Have Lower Stroke Risk 2Health News:Obesity Should Not Be a Hollywood Punchline, Weight Loss Doc Says 2Health News:Performance Physical Therapy Awarded with Jayne L. Snyder Private Practice of the Year 2014 2Health News:Scientists to Stanford: Research Shows Brain Exercises Can Work 2Health News:Scientists to Stanford: Research Shows Brain Exercises Can Work 3Health News:Scientists to Stanford: Research Shows Brain Exercises Can Work 4Health News:Lice Troopers Announces New Lice Treatment Clinic in Coral Gables to Service Key Biscayne, Coconut Grove, Kendall, Brickell & South Miami 2
... some traditional risk factors, study finds, , , TUESDAY, July ... smoking, Japanese men are far less likely to have ... or Japanese-American men, a difference that researchers believe stems ... "Japanese living in Japan eat fish every day, about ...
... Society for Biochemistry and Molecular Biology (ASBMB) has selected ... Howard K. Schachman Public Service Award, the society,s highest ... for their outstanding commitment in supporting public health over ... States but around the world, through the Bill & ...
... Va., July 29 - Burgess(TM) a leading,Medicare-based ... an expanded agreement with its Woodland Hills, ... is a publicly traded, managed health care ... health plans and,government contracts subsidiaries provide health ...
... Casa Saba,S.A.B. de C.V. (SAB) announces the passing of the ... past Sunday, July 27, 2008. The,Group,s management and staff members ... condolences to his widow and children., In homage ... to operate,based on his principles of hard work and his ...
... RESEDA, Calif., July 29 The Los Angeles Jewish ... applications,as it enters its second session as one of ... of nursing., The Annenberg School of Nursing offers ... the state-required exam for licensure. The,intensive vocational nursing program ...
... drug-taking athletes from damaging sport by using performance enhancing ... according to a major four-decade review by three of ... , Writing in the August issue of the European-based ... significant advances have been made in the fight against ...
Cached Medicine News:Health News:Fondness for Fish Keeps Japanese Hearts Healthy 2Health News:Fondness for Fish Keeps Japanese Hearts Healthy 3Health News:ASBMB honors Bill and Melinda Gates with Schachman Award 2Health News:Burgess Announces Expanded Software Partnership With Health Net 2Health News:Los Angeles Jewish Home's New Annenberg School of Nursing Seeks Applicants for Second Session of Precedent-Setting U.S. Senior-Care Facility's School of Nursing 2Health News:Los Angeles Jewish Home's New Annenberg School of Nursing Seeks Applicants for Second Session of Precedent-Setting U.S. Senior-Care Facility's School of Nursing 3Health News:Scientists race to stay ahead of the drug-taking and genetic manipulation that threatens sport 2Health News:Scientists race to stay ahead of the drug-taking and genetic manipulation that threatens sport 3
(Date:12/15/2014)... 15, 2014 Registreer nu via  ... und 20. Februar sind alle akkreditierten pharmazeutischen ... ECOSYSTEM PARTNER PROGRAMM ™ 2015 in ... Diese Tagung soll dazu beitragen, der ... die neue profitablen Unternehmensdienstleistungen, die für Apotheken ...
(Date:12/15/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/32cmct/inferior_vena ) has ... (IVC) Filters - Global Trends, Estimates and Forecasts, 2012-2018" ... http://photos.prnewswire.com/prnh/20130307/600769 Global Inferior Vena Cava ... by 2016. The North America ... while Europe claims approximately 27% ...
(Date:12/15/2014)... and HERZLIYA PITUACH, Israel , Dec. ... IMNP ) announced today that its Board of ... succeeding Dr. Daniel Teper who continues as Chief ... of Immune,s Board of Directors since 2013. Immune,s ... delighted to represent the interest of shareholders and to continue ...
Breaking Medicine Technology:Symposium über Aegates Ecosystem-Partner-Programm für sichere Medikamente vom 19. - 20. Februar 2015 in Amsterdam 2Inferior Vena Cava (IVC) Filters - Global Trends, Estimates and Forecasts, 2012-2018 2Inferior Vena Cava (IVC) Filters - Global Trends, Estimates and Forecasts, 2012-2018 3Inferior Vena Cava (IVC) Filters - Global Trends, Estimates and Forecasts, 2012-2018 4Immune Pharmaceuticals Elects Daniel Kazado as New Chairman of the Board. 2Immune Pharmaceuticals Elects Daniel Kazado as New Chairman of the Board. 3Immune Pharmaceuticals Elects Daniel Kazado as New Chairman of the Board. 4
... Oct. 13, 2011 K-V Pharmaceutical Company (the ... of Obstetricians and Gynecologists (ACOG) and Society for ... that ensures healthcare providers, patients, and the payer ... information update emphasizes that previous ACOG and SMFM ...
... 13, 2011 IVD Technology , ... diagnostics technologies including research, development, and manufacturing, today announced ... emerging trend in the industry – ... (CONTACT:   http://photos.prnewswire.com/prnh/20101214/LA16070LOGO ) The featured speaker ...
Cached Medicine Technology:K-V Pharmaceutical Comments on ACOG and SMFM Information Update Regarding 17-Alpha Hydroxyprogesterone Caproate - FDA-Approved Makena™ and Compounded 17P 2K-V Pharmaceutical Comments on ACOG and SMFM Information Update Regarding 17-Alpha Hydroxyprogesterone Caproate - FDA-Approved Makena™ and Compounded 17P 3K-V Pharmaceutical Comments on ACOG and SMFM Information Update Regarding 17-Alpha Hydroxyprogesterone Caproate - FDA-Approved Makena™ and Compounded 17P 4K-V Pharmaceutical Comments on ACOG and SMFM Information Update Regarding 17-Alpha Hydroxyprogesterone Caproate - FDA-Approved Makena™ and Compounded 17P 5K-V Pharmaceutical Comments on ACOG and SMFM Information Update Regarding 17-Alpha Hydroxyprogesterone Caproate - FDA-Approved Makena™ and Compounded 17P 6K-V Pharmaceutical Comments on ACOG and SMFM Information Update Regarding 17-Alpha Hydroxyprogesterone Caproate - FDA-Approved Makena™ and Compounded 17P 7K-V Pharmaceutical Comments on ACOG and SMFM Information Update Regarding 17-Alpha Hydroxyprogesterone Caproate - FDA-Approved Makena™ and Compounded 17P 8Distinguished Speaker Dr. Elizabeth Mansfield Joins IVD Technology for Upcoming Webcast: The Regulation of Companion Diagnostics: Current Status and Updates 2Distinguished Speaker Dr. Elizabeth Mansfield Joins IVD Technology for Upcoming Webcast: The Regulation of Companion Diagnostics: Current Status and Updates 3
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: