Navigation Links
Enzyme Beneficial to Alzheimer's Plays Darker Role in Other Dementia
Date:4/23/2008

Finding could mean changing animal models used for future research

WEDNESDAY, April 23 (HealthDay News) -- An enzyme shown to help suppress development of Alzheimer's disease appears to hasten progress of a related but far less common type of dementia, according to a new study.

The surprising findings, published in the April 22 online issue of The Journal of Clinical Investigation, are significant, because individuals with frontotemporal dementia with parkinsonism-17 -- a relatively rare hereditary form of dementia -- are often used as models for studying Alzheimer's disease.

Alzheimer's disease and frontotemporal dementia each develop as a result of too many tau proteins accumulating and causing tangled lesions in the brain's neurons. These knotted nerve cells eventually choke off the brain cells responsible for memory.

However, individuals with frontotemporal dementia have mutations in the gene, known as P301L, encoding tau. These mutations have not been found in individuals with Alzheimer's.

Researchers found in mouse models and human cells that boosting levels of the prolyl isomerase (Pin1) enzyme, previously shown to aid in "detangling" tau in Alzheimer's disease, helps break down the tau proteins. However, the same experiments on mice with the genetic mutations in the tau that cause frontotemporal dementia resulted in increased and accelerated tau protein tangling.

"First, we have established a proof of concept that boosting Pin1 activity may offer a new idea for preventing or even treating the tau pathology and neurodegeneration in Alzheimer's disease," senior author Kun Ping Lu, a scientist in the Division of Hematology/Oncology at Beth Israel Deaconess Medical Center, said in a prepared statement. "And, second, given that no tau mutation is found in Alzheimer's patients, this research suggests that it would be prudent to not use P301L tau as an Alzheimer's disease model, especially when screening and testing drugs, as it may produce diametrically opposite effects."

More information

The Alzheimer's Association has more about current treatments for Alzheimer's.



-- Kevin McKeever



SOURCE: Beth Israel Deaconess Medical Center, news release, April 22, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Blood pressure enzyme can have tumor-sensing role
2. Enzyme complex could be key to new cancer treatments
3. Elevated liver enzymes associated with higher future mortality
4. Enzyme structure reveals new drug targets for cancer and other diseases
5. Genzyme Delivers Strong Fourth Quarter to Conclude Outstanding Year
6. AGI Dermatics Data Indicates 8 Oxo-Guanine Repair Enzyme OGG1 Encapsulated in Liposomes, Reduces MMP-1, Increases Collagen and Enhances DNA Repair
7. First look at an enzyme target for antibacterial and cancer drugs
8. Caught in the act: The dynamic dance of enzymes
9. McGill researchers link enzyme to breast cancer malignancy
10. Telomerase enzyme structure provides significant new target for anti-cancer therapies
11. Genzyme Receives FDA Response Letter on Synvisc-One(TM)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2017)... ... July 25, 2017 , ... ... the launch of their partnership to provide the Pharmacist eCare Plan ... platform in the country with the ability to develop the Pharmacist eCare Plan, ...
(Date:7/25/2017)... ... July 25, 2017 , ... Dr. Gina Negrette, a ... more than a decade of experience in psychiatry, treating clients in diverse settings, ... eating disorders, psychotic and manic conditions, as well as those who were fighting ...
(Date:7/24/2017)... (PRWEB) , ... July 24, ... ... Marketing Director,      (407) 916-7235, kklaproth(at)robinsmorton(dot)com , Robins & Morton, ... together to celebrate the structural topping out of the new Destination Medical ...
(Date:7/24/2017)... ... July 24, 2017 , ... Horizon Goodwill Industries, ... opportunity that helps high school girls succeed in STEM programs as well as ... Goodwill will host over 20 high school girls at their corporate headquarters on ...
(Date:7/24/2017)... ... July 24, 2017 , ... Axiad IDS , a leading provider ... partnered with WALLIX to expand its solution to help government contractors more ... a number of ways to address the authentication requirements within NIST SP800-171, but ...
Breaking Medicine News(10 mins):
(Date:7/20/2017)... , July 20, 2017  Prime Therapeutics LLC (Prime) ... Gavras , M.D., following today,s Institute for Clinical and Economic ... on the effectiveness and value of abuse-deterrent formulations (ADF) ... the policy roundtable at the meeting. ... a material cost benefit to the use of abuse-deterrent formulations ...
(Date:7/14/2017)... -- Endo International plc (NASDAQ: ENDP ) will announce ... of its senior management team will host a conference call and ... The dial-in number to access the call is ... the passcode is 45397076. Please dial in 10 minutes prior to ... A replay of the call will be available from August 8, ...
(Date:7/13/2017)...  New York City-based market research firm Kalorama Information notes ... of.  From new products to new costs, to the threat ... completed study, Potential Pipeline Disruptors . Among ... 1.  Age-Driven Growth - True Impact Moment Arriving   ... impact the growing population and, to a more extreme extent, ...
Breaking Medicine Technology: