Navigation Links
Enzalutamide adds 5 months survival in late-stage prostate cancer
Date:8/16/2012

Results of a phase III clinical trial of the drug Enzalutamide, published yesterday in the New England Journal of Medicine, show the drug extends life by an average five months in the most advanced stages of prostate cancer.

"This is a major advance. Not only do we see more survival benefit than from traditional chemotherapy, but the side effects of Enzalutamide are much lower. It provides both more benefit and less harm you get the quantification of more life, but also see quality of life improvements," says study co-author, Thomas Flaig, MD, medical director of the University of Colorado Cancer Center's Clinical Investigations Shared Resource and associate professor of medicine at the University of Colorado School of Medicine.

The study, known by the acronym AFFIRM, followed 1199 patients with prostate cancer that had progressed despite both hormonal and chemotherapy treatments, with 2/3 of patients receiving the drug Enzalutamide versus control. Median overall survival for patients in the treatment arm of the trial was 18.4 months compared to 13.6 months for patients in the placebo arm. In addition to prolonged survival, patients given Enzalutamide showed meaningful improvement in other measures including PSA blood levels, an increase from 3.0 months to 8.3 months in time until PSA progression, and an increase from 2.9 months to 8.3 months in overall progression-free survival.

The once-a-day oral drug works by blocking prostate cancer's ability to supply itself with androgens hormones including testosterone that otherwise drive the cancer's growth. It does this by binding to cancer cells' androgen receptors the waving tentacles on the outsides of cells that are designed to grab specific molecules as they float past. Enzalutamide plugs these receptors, removing their ability to grab androgen.

This out-competition for space in androgen receptors is not a new strategy. But when treated with existing anti-androgen dr
'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. June 2012 marks a milestone for International Urogynecology Associates as Dr. Robert D. Moore and Dr. John R. Miklos perform their 24th Neovagina Surgery in 24 months
2. New Drug Appears to Extend Survival in Advanced Prostate Cancer Patients
3. Study: Vaccine targets malignant brain cancer antigens, significantly lengthens survival
4. Spending more on trauma care doesnt translate to higher survival rates
5. UT MD Anderson study finds link between depressive symptoms and cancer survival
6. Depression Could Shorten Cancer Survival, Study Suggests
7. Coordinated Care Boosts Cardiac Arrest Survival: Study
8. New research seeks to improve survival for myeloma and lymphoma patients
9. Survival rates for premature babies in high-level NICUs are better than previously reported
10. HPV improves survival for African-Americans with throat cancer
11. Access to clinical trials drives dramatic increases in survival from childhood cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2013)... News) -- Over the next two decades, the cost ... to more than double, topping more than $180 billion ... factor driving the increase: an aging population. The report, ... Stroke Association, was published May 22 in the journal ... health care system," Dr. Bruce Ovbiagele, chairman of the ...
(Date:5/22/2013)... HealthDay Reporter , , WEDNESDAY, May 22 (HealthDay ... great deal of suffering, but new research indicates the ... else entirely -- a smaller brain. , , Already ... of depression, scientists wanted to determine if having both ... size -- about 2 percent -- isn,t alarming, study ...
(Date:5/22/2013)... Johns Hopkins researchers report that hospitals may be ... are complicated by preventable bloodstream infections contracted in ... new study, reported online in the American ... that an ICU patient who develops an avoidable ... times more to care for than a similar ...
(Date:5/22/2013)... 22, 2013 Award Presented at the ... press release here: http://bit.ly/13DkFfk , Merrill Corporation ... “Information Management Product/Service of the Year” at the 7th ... The Colony Hotel in Palm Beach, Florida. , ... room (VDR) solution that optimizes the due diligence ...
(Date:5/22/2013)... 22, 2013 Phelps Memorial Hospital Center ... Westchester Lung Nodule Center for individuals who would like ... care. Lung cancer is the deadliest form of cancer for ... the U.S. die from lung cancer than from breast, colon ... early detection increases survival rates. It is well established ...
Breaking Medicine News(10 mins):Health News:Cost of Treating Strokes in U.S. Could Soar to $180B Annually by 2030: Report 2Health News:Cost of Treating Strokes in U.S. Could Soar to $180B Annually by 2030: Report 3Health News:Having Both Migraines, Depression May Mean Smaller Brain 2Health News:Having Both Migraines, Depression May Mean Smaller Brain 3Health News:Hospitals profit when patients develop bloodstream infections 2Health News:Hospitals profit when patients develop bloodstream infections 3Health News:Hospitals profit when patients develop bloodstream infections 4Health News:Merrill DataSite New Press Release: Merrill DataSite® Virtual Data Room Honored as “Information Management Product/Service of the Year” 2Health News:Merrill DataSite New Press Release: Merrill DataSite® Virtual Data Room Honored as “Information Management Product/Service of the Year” 3Health News:Phelps Memorial Hospital Center Establishes The Westchester Lung Nodule Center To Diagnose And Administer Lung Cancer Care 2Health News:Phelps Memorial Hospital Center Establishes The Westchester Lung Nodule Center To Diagnose And Administer Lung Cancer Care 3
... Recent study reports that women don’t have to worry about their ... fertility is higher only in their thirties. // Women don’t have ... be a constraint for conception of babies. Researchers have found from ... as man as increased considerably. The fertility rate of women in ...
... as formed a new cabinet committee to plan strategies to ... has said that though the United Kingdom //Government has taken ... flu spread but the committee feels still a lot has ... ,The committee feels that the Government should organize the food ...
... Motion has been developed by University of Toronto scientists with ... again. The device makes the muscles// work again by sending ... called functional electrical stimulation or FES, is unlike similar therapies ... is not dependent on the machine. ,Instead, the ...
... it takes to get pregnant or conceive the sex of the ... by Dutch reserachers. //The sample size was 5,283 women who gave ... ,Among the 498 women who took longer than 12 months ... whereas the proportion of male births among the 4,785 women with ...
... UK Parliamentarian Roger Williams has called for a ban ... the production of 6,000 types of medicines, food and ... the sweetener, which is used in cereal, chocolate and ... published reports that aspartame caused cancer in rats. Doses ...
... the Government in treating drug addicts is beginning to yield ... users seeking treatment in 2004. Heroin users accounted for 8,000 ... the number of people trying to get back to normal ... the figures, which also said that the percentage of heroin ...
Cached Medicine News:
(Date:5/22/2013)... , May 22, 2013  Flagship Ventures, a ... on healthcare and sustainability, today announced the appointment ... a Senior Partner. In this role, Mr. Bancel ... companies. In addition to working closely ... also serves as President and Chief Executive Officer ...
(Date:5/22/2013)... and TORONTO , May 22, ... today that John Mon , Chief Operating ... Conference on Thursday, May 30, 2013 in New ... The Company,s presentation is scheduled to begin at ... webcast. To access the webcast, go to:   http://wsw.com/webcast/marcum/mfs.v/   ...
(Date:5/22/2013)... May 22, 2013 While many parents may ... to drink at home under adult supervision keeps kids ... truth is that there are serious negative consequences for ... and The Treatment Research Institute (TRI) ... resource for parents and caregivers to help inform them ...
Breaking Medicine Technology:Life Science Industry Veteran Stephane Bancel Joins Flagship Ventures 2Life Science Industry Veteran Stephane Bancel Joins Flagship Ventures 3Medifocus, Inc. to Present At The Second Annual Marcum LLP MicroCap Conference 2Medifocus, Inc. to Present At The Second Annual Marcum LLP MicroCap Conference 3Myths Debunked: Underage Drinking of Alcohol at Home Leads to Real Consequences for Both Parents and Teens 2Myths Debunked: Underage Drinking of Alcohol at Home Leads to Real Consequences for Both Parents and Teens 3Myths Debunked: Underage Drinking of Alcohol at Home Leads to Real Consequences for Both Parents and Teens 4Myths Debunked: Underage Drinking of Alcohol at Home Leads to Real Consequences for Both Parents and Teens 5Myths Debunked: Underage Drinking of Alcohol at Home Leads to Real Consequences for Both Parents and Teens 6Myths Debunked: Underage Drinking of Alcohol at Home Leads to Real Consequences for Both Parents and Teens 7
... July 14 D3 Radiation Services announced today  that the ... reduce errors in the delivery of radiation therapy--as a Practice Quality Improvement ... , , ... radiation oncology physicists can order a comprehensive audit of their beam data ...
... 14 Mylan Inc. (Nasdaq: MYL ) ... received final approval from the U.S. Food and Drug ... for Nabumetone Tablets USP, 500 mg and 750 mg. ... therapeutically equivalent to Nabumetone Tablets, a treatment for osteoarthritis ...
Cached Medicine Technology:eDataAudit Receives Approval from the American Board of Radiology 2Mylan Receives Approval for Nabumetone Tablets 2
Straight, with guard. Ideal for multi-directional manipulation....
Vaulted shank with guard....
Vaulted shank. For engaging the inferior haptic without touching the dome of the IOL....
... adjusted for perfect focus where it's needed ... This, along with Keeler's wide angle light ... the patient's pupil size, you will see ... Lithium-ion technology provides a longer life battery ...
Medicine Products: