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EntreMed Teams with JSB-Partners to Expedite Partnering of its Aurora Kinase Program
Date:8/12/2008

Additional Resources to Accelerate ENMD-2076 Partnering Efforts

ROCKVILLE, Md., Aug. 12 /PRNewswire-FirstCall/ -- EntreMed, Inc. (Nasdaq: ENMD), a clinical-stage pharmaceutical company developing therapeutics for the treatment of cancer and inflammatory diseases, today announced that it has engaged JSB-Partners, a global life sciences advisor, to enhance business development and partnering activities for its lead Aurora A/angiogenesis kinase inhibitor, ENMD-2076.

(Logo: http://www.newscom.com/cgi-bin/prnh/20010620/ENMDLOGO )

ENMD-2076 is a novel, orally-active, selective kinase inhibitor with potent activity against Aurora A and tyrosine kinases linked to the promotion of cancer and inflammatory diseases. ENMD-2076 has a unique combination of target activities including cell cycle inhibition (Aurora A), antiangiogenesis (VEGFR, FGFR, PDGFR), and antiproliferative (Flt-3, Src, c-Kit) kinase inhibition. ENMD-2076 has demonstrated substantial 1) dose-dependent efficacy, both as a single agent and in combination with approved therapies, in multiple preclinical models; and 2) tumor regression in breast, colon, leukemia, and other cancers. ENMD-2076 has shown a favorable safety profile in preclinical studies without cardiovascular toxicity. EntreMed has strong intellectual property around the lead compound, ENMD-2076, and over 600 analogs. ENMD-2076 is currently in a Phase 1 study in refractory cancer patients. A Phase 1 study in either multiple myeloma or hematological cancers is planned for the second half of 2008.

"Consistent with our strategy, we have been actively seeking partnership opportunities for our unique, orally-active, s
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SOURCE EntreMed, Inc.
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