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EntreMed Reports Clinical Program Progress and Company Update
Date:11/12/2008

ts. The Company is engaged in

partnering discussions for the Panzem(R) RA program.

Mr. Burns commented on the update, "Increased royalty revenues and strategic cost reductions should place the Company in a position to weather the current market conditions into 2010. Aggressive partnering efforts for our Aurora/angiogenesis inhibitor, ENMD-2076, are underway, which will help accelerate development of this exciting compound and provide the financial resources to maintain our clinical development plan. These are difficult market conditions but we will continue to be resilient in our strategies. While our stock price has suffered, we have continued to make excellent clinical progress. I am confident in our pipeline of multi-mechanism drugs for cancer and inflammatory diseases and I believe that we remain on course to achieve our clinical and partnering milestones."

About EntreMed

EntreMed, Inc. is a clinical-stage pharmaceutical company developing therapeutic candidates primarily for the treatment of cancer and inflammation. MKC-1, an oral cell-cycle regulator with activity against the mTOR pathway, is currently in multiple Phase 2 clinical trials for cancer. ENMD-2076, a selective angiogenic kinase inhibitor, and ENMD-1198, a novel antimitotic agent are in Phase 1 studies in advanced cancers. The Company also has an approved IND application for Panzem(R) in rheumatoid arthritis. EntreMed's goal is to develop and commercialize new compounds based on the Company's expertise in angiogenesis, cell cycle regulation, cell signaling and inflammation - processes vital to the treatment of cancer and other diseases, such as rheumatoid arthritis. Additional information about EntreMed is available on the Company's web site at http://www.entremed.com and in various filings with the Securities and Exchange Commission.

Forward Looking Statements

This release contains forward-looking state
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