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EntreMed Reports Clinical Program Progress and Company Update
Date:11/12/2008

ng. Phase 1 results are anticipated in the first half of 2009. A

second Phase 1 study in patients with multiple myeloma is planned to

begin later this year. The Company is engaged in partnering discussions

for the ENMD-2076 program.

-- MKC-1 - The primary response rate endpoint has been met for the efficacy

portion of the MKC-1 Phase 1/2 study in combination with Alimta(R)

(pemetrexed) in patients with non-small cell lung cancer. EntreMed is

considering possible options for further studies in NSCLC patients which

could include continuation of the current single arm study or a

randomized Phase 2 study in the same patient population if additional

financial resources are available.

-- ENMD-1198 - The Phase 1 study in advanced cancer patients is nearing

completion. A dose-limiting toxicity has been reached. The Phase 1

program may be expanded to identify combination therapies and target

indications. The mechanism-of-action for ENMD-1198 indicates that

prostate cancer may be a key indication. Possible next steps for the

clinical development of ENMD-1198 are being considered in light of our

objectives for 2009.

-- Panzem(R) RA - The Company completed a healthy volunteer study and

results were submitted to the FDA. The study results reaffirmed the

safety of Panzem(R), even at higher doses than are anticipated for the

treatment of rheumatoid arthritis. Based on the FDA's review, the

Company now has a clear path forward for clinical development and will

consider its options relative to our objectives for 2009. Possible next

steps for the RA program could include a drug-drug interaction (DDI)

clinical trial with methotrexate and chronic animal toxicology studies,

followed by a Phase 2 study in RA patien
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SOURCE EntreMed, Inc.
Copyright©2008 PR Newswire.
All rights reserved

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