EntreMed Presents Results for Panzem(R) NCD Phase 2 Ovarian Ca...( Results Demonstrate Act...),Health

Results Demonstrate Activity in Advanced Disease

ROCKVILLE, Md., Oct. 24 /PRNewswire-FirstCall/ -- EntreMed, Inc. (Nasdaq: ENMD), a clinical-stage pharmaceutical company developing therapeutics for the treatment of cancer and inflammatory diseases, today announced the presentation of results for its Phase 2, open-label study for Panzem(R) NCD (2ME2 or 2-methoxyestradiol) in patients with ovarian cancer. The results were presented by Dr. Daniela Matei, principal investigator for the study representing the Hoosier Oncology Group, at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics being held this week in San Francisco, California.

(Logo: http://www.newscom.com/cgi-bin/prnh/20010620/ENMDLOGO )

Data from the Phase 2 study demonstrate that Panzem(R) NCD, administered as a single agent in patients with platinum refractory epithelial ovarian cancer, resulted in one patient with a confirmed partial response of their CA- 125. Five patients, out of the 18 patients enrolled, achieved stable disease lasting greater than three months. Panzem(R) NCD was well tolerated and no significant neuropathy, myelosuppression or thromboembolic side effects were reported. Three patients remained on study for more than 6 months and two of these patients are still on study.

Data from in vitro studies demonstrated that 2ME2 has activity against a variety of ovarian carcinoma cell lines including those resistant to other chemotherapeutic agents. In preclinical models of ovarian cancer, 2ME2 has shown a significant survival advantage compared to animals that did not receive treatment. Furthermo
'/>"/>