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Entire T-cell receptor repertoire sequenced revealing extensive and unshared diversity
Date:2/23/2011

ce. "This shows that certain sequences are more favored than others, most likely because they are more effective in recognizing specific types of infections or mutations," said Holt.

By cataloging the baseline diversity of the immune repertoire in a healthy individual, Holt explained that future studies would be able to then recognize how the repertoire is disturbed in cases of immune challenge, such as infectious disease or organ transplantation, and furthermore, may assist in the development of new vaccines.


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Contact: Peggy Calicchia
calicchi@cshl.edu
516-422-4012
Cold Spring Harbor Laboratory
Source:Eurekalert

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