Navigation Links
Entire T-cell receptor repertoire sequenced revealing extensive and unshared diversity
Date:2/23/2011

February 24, 2011 T-cell receptor diversity in blood samples from healthy individuals has been extensively cataloged for the first time in a study published online today in Genome Research (www.genome.org), setting the stage for a better understanding of infectious disease, cancer, and immune system disorders.

Adaptive immunity is mediated by T-cells, a white blood cell that identifies and attacks cells that may be infected with viruses or contain cancer-causing mutations. To recognize a wide array of potentially infectious agents or cancer-causing mutations, gene shuffling creates a highly variable and diverse collection of T-cell receptor sequences.

While the diversity of sequences in immune cell repertoires has been investigated previously, no study had yet been able to capture the entire range present in an individual sample. Now, using next-generation sequencing technology, researchers in Canada have identified essentially all T-cell receptor variants in blood samples, identifying more than one million unique sequences.

Dr. Robert Holt of the BC Cancer Agency and Simon Fraser University, senior author of the report, explained that this study is the first to establish that while there is high T-cell diversity in a standard blood sample, it does not give the entire picture. "This is only part of the diversity that would be present within a person's entire body," Holt said, "but now we know that although the diversity is very large, it is ultimately limited, and it is measureable."

The group found that some T-cell receptor sequences are common, some are rare, and the repertoire can change over time. The individual repertoire was then compared to that of two other individuals, showing that only a minority of sequences is shared between them.

Interestingly, they noted that for sequences that were shared, different gene shuffling events had often generated the same sequence. "This shows that certain sequences are more favored than others, most likely because they are more effective in recognizing specific types of infections or mutations," said Holt.

By cataloging the baseline diversity of the immune repertoire in a healthy individual, Holt explained that future studies would be able to then recognize how the repertoire is disturbed in cases of immune challenge, such as infectious disease or organ transplantation, and furthermore, may assist in the development of new vaccines.


'/>"/>

Contact: Peggy Calicchia
calicchi@cshl.edu
516-422-4012
Cold Spring Harbor Laboratory
Source:Eurekalert

Related medicine news :

1. Entire Family Genome Sequenced for First Time
2. Yantra Mat USA Introduces the Yantra Kit: Bringing the Health Benefits of Acupressure to the Entire Body
3. Study finds key protein controls T-cell proliferation
4. Scott & White Healthcare study aimed at T-cell lymphoma
5. Pharmacokinetic/Pharmacodynamic Data Support Further Development of Tobiras Next-Generation CCR5 Receptor Antagonist
6. New Guidelines Issued on Hormone Receptor Testing for Breast Cancer
7. Cell study finds receptor can fight tamoxifen-resistant breast cancer cells
8. Estrogen receptor status of HER2+ breast cancer correlates with response to anti-HER therapies
9. Androgen receptor may explain male dominance in liver cancer
10. CD74 serves as a survival receptor on colon epithelial cells
11. Nicotine binding to receptor linked to breast cancer cell growth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... ... non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as a method ... —Johnson is one of the first doctors to perform the treatment. Orthobiologics are ...
(Date:6/24/2016)... Los Angeles, CA (PRWEB) , ... June 24, 2016 , ... ... plastic surgery procedures that most people are unfamiliar with. The article goes on to ... known procedures, but also many of these less common operations such as calf and ...
(Date:6/24/2016)... ... , ... Marcy was in a crisis. Her son James, eight, was out of control. Prone ... physically. , “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If ... at my other children and say he was going to kill them. If we ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. ... accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas of orthodontics, ... and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic ...
(Date:6/24/2016)... Plano, TX (PRWEB) , ... June 24, 2016 , ... ... taking part in Genome magazine’s Code Talker Award, an essay contest in which patients ... for an award to be presented at the 2016 National Society of Genetic Counselors ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Tenn. , June 24, 2016  Arkis ... providing less invasive and more durable cerebrospinal fluid ... in funding.  The Series-A funding is led by ... Lighthouse Fund, and other private investors.  Arkis, new ... neurosurgical instrumentation and the market release of its ...
(Date:6/23/2016)... , June 23, 2016 Any dentist who has ... of the current process. Many of them do not even ... technical difficulties and high laboratory costs involved. And those who ... it at such a high cost that the majority of ... Dr. Parsa Zadeh , founder of Dental Evolutions ...
(Date:6/23/2016)... Roche (SIX: RO, ROG; OTCQX: RHHBY) announced ... BRAHMS PCT (procalcitonin) assay as a dedicated testing solution ... this clearance, Roche is the first IVD company in ... sepsis risk assessment and management. PCT is ... levels in blood can aid clinicians in assessing the ...
Breaking Medicine Technology: