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Enlightening cancer cells
Date:7/1/2014

cells, activation of the engineered receptors causes changes in cell morphology, proliferation and gene expression, characteristic of increased cancer malignancy. In blood cells, activation leads to cell sprouting, typical of the formation of new blood vessels.

The development of RTKs regulated through light-activated dimerization by Janovjak and Grusch is the first instance of light-activated dimerization of mammalian receptors. The engineered receptors can be precisely controlled by a light intensity easily achieved in microscopes and in animal models. The newly developed receptors trigger complex cellular programs in both cancer and blood endothelial cells. These cells represent new models in which behavior is under light control and which can, for instance, be used for new methods to identify drugs. In contrast to cancer, where uncontrolled activation of cell signaling results in features linked to malignancy, light activation of signaling may rescue cell survival and function in degenerative disease.


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Contact: Oliver Lehmann
oliver.lehmann@ist.ac.at
43-067-640-12562
Institute of Science and Technology Austria
Source:Eurekalert  

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