Navigation Links
Enhancing bioavailability of healthful components in food using nanoparticle design
Date:1/17/2014

AMHERST, Mass. - Food scientist Hang Xiao of the University of Massachusetts Amherst recently received a four-year, $491,220 grant to study the biochemical fate of nanoemulsion-based food delivery systems in the gastrointestinal (GI) tract, hoping to re-shape them and enhance the absorption of beneficial food components encapsulated in delivery systems.

Food biochemists like Xiao believe that if taken up in appropriate amounts and forms, certain food components known as nutraceuticals might benefit human health by providing anti-inflammatory or anti-cancer effects. Nutraceuticals include flavonoids and carotenoids in fruits and vegetables, for example.

This project, supported by the U.S. Department of Agriculture's National Institute of Food and Agriculture, will focus on manipulating the structure and composition of nano-emulsion delivery systems to modify the fate of encapsulated nutraceuticals in the GI tract to enhance their bioavailability.

"In the last decade, knowledge has been advancing about how to effectively deliver beneficial components in food. This research will allow us to direct the assembly of nano-emulsion droplets to create characteristics that will dictate how they are digested and absorbed," Xiao explains. "This would be a model for nutraceutical delivery in a wide range of food products. Someday prepared foods may help lower our risk of cancer, for example."

Specifically, using both cell culture and animal models, Xiao and colleagues will design lipid nanoparticles at three stages: From nano-emulsion droplets containing nutraceuticals, to mixed micelles and finally to chylomicrons. To start this process, digestion physiochemically disassembles nano-emulsion droplets. The resulting chemical components are then assembled into mixed micelles in the small intestine, where epithelial cells called enterocytes take them up. There they are reassembled into chylomicrons and absorbed into blood circulation through the lymph system.

The scientists want to influence the size and composition of chylomicrons, because these characteristics dictate the fate of nutraceuticals encapsulated in the chylomicrons. Certain sizes and compositions are better able to deliver nutraceuticals to the lymph system, which protects nutraceuticals from being cleared by the liver. This will enhance bioavailability of flavonoids and other beneficial compounds to the body, potentially offering health benefits.

"We're basically utilizing what already happens in our bodies all the time, but introducing food-grade nano-emulsion systems that can influence the nature of mixed micelles as well as chylomicrons," says Xiao. "It's safe, it's all digested and simply delivers beneficial food components to a greater extent than if the system was left alone."

Xiao, a specialist in how food components interact with biochemical processes in the GI tract, will work with UMass Amherst colleagues including Julian McClements, an expert in the design of nano-scale delivery systems, and Eric Decker, an expert in food chemistry. This team is among the world's most accomplished groups at using food-grade delivery systems to enhance health benefits of food components.


'/>"/>
Contact: Janet Lathrop
jlathrop@admin.umass.edu
413-545-0444
University of Massachusetts at Amherst
Source:Eurekalert  

Related medicine news :

1. 123Greetings.com Launches German Ecards Under World Languages Category, Enhancing Its Portfolio Of Multilingual Greetings
2. PolyU Develops Anti-Counterfeiting Ink for Enhancing Product Authenticity and Traceability
3. The Secret to Revealing and Enhancing Younger-Looking Skin from Sublime Beauty
4. Enhancing RNA interference
5. Enhancing Compatibility and Boosting Performance; NEXCOM Introduces the ICES 670 COM Express Module Based on 4th Generation Intel® Core™ Processor
6. Research Suggests that Lack of Exercise Drive is Genetic, Making Energy Enhancing Supplements Like Prescopodene Beneficial For Sticking to Your Exercise Routine
7. NYU and NYU Langone researchers devise method for enhancing CEST MRI
8. Researchers identify new pathway, enhancing tamoxifen to tame aggressive breast cancer
9. BOMI International and Transwestern Partner to Offer Property and Facility Staff Skill-Enhancing Education Programs
10. Continuing Education Provider HomeCEUConnection.com Adds New Career Enhancing Video Courses to Online Catalog
11. Delray Recovery Center Treats Steroid and Performance Enhancing Drug Abuse
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Enhancing bioavailability of healthful components in food using nanoparticle design
(Date:9/21/2017)... Va. (PRWEB) , ... September 21, 2017 , ... ... with a different approach to addiction recovery at a time when Virginia faces ... deaths resulting from drug overdose, a staggering increase of 38 percent from 2015, ...
(Date:9/21/2017)... ... September 21, 2017 , ... ... the acquisition of Isle at Kingwood Assisted Living and Memory Care located at ... retirement community with 55 assisted living apartments, 43 memory care apartments and 23 ...
(Date:9/21/2017)... ... September 21, 2017 , ... In ... and Clark College Emeritus Professor of Education Gregory A. Smith examines student privacy ... Asleep at the Switch: Schoolhouse Commercialism, Privacy, and the Failure of Policymaking . ...
(Date:9/20/2017)... CHARLOTTE, NC (PRWEB) , ... September 20, 2017 ... ... for Transformation and Centers of Excellence (CoE) with the latest Artificial Intelligence (AI) ... newly designed presence offers quick and easy access to essential information that offers ...
(Date:9/20/2017)... , ... September 20, 2017 , ... ... one of the Best Places to Work in the Research Triangle for 2017. ... Once nominated, a company had to meet a threshold in employee participation--a percentage ...
Breaking Medicine News(10 mins):
(Date:9/7/2017)... Ind. , Sept. 7, 2017  Zimmer Biomet ... in musculoskeletal healthcare, today announced that it will be ... Global Healthcare Conference at the Grand Hyatt hotel in ... 11, 2017 at 11:40 a.m. Eastern Time. ... via Zimmer Biomet,s Investor Relations website at http://investor.zimmerbiomet.com ...
(Date:9/6/2017)... Sept. 6, 2017 NeuroRx, a clinical stage biopharma ... and Behavior (ASIB), has been granted Fast Track status by ... of NRX-100 (ketamine HCl) followed by NRX-101 (D-cycloserine + lurasidone). ... trial of this sequential therapy targeting patients who are admitted ... ...
(Date:9/5/2017)... LONDON , Sept. 5, 2017  Just 18 ... Valid Insight is pleased to announce the appointment of ... Tammy Wynne , Dominic Jones-Phillips and ... from industry. ... a team of market access writers. She has over ...
Breaking Medicine Technology: