Navigation Links
Enhancing bioavailability of healthful components in food using nanoparticle design
Date:1/17/2014

AMHERST, Mass. - Food scientist Hang Xiao of the University of Massachusetts Amherst recently received a four-year, $491,220 grant to study the biochemical fate of nanoemulsion-based food delivery systems in the gastrointestinal (GI) tract, hoping to re-shape them and enhance the absorption of beneficial food components encapsulated in delivery systems.

Food biochemists like Xiao believe that if taken up in appropriate amounts and forms, certain food components known as nutraceuticals might benefit human health by providing anti-inflammatory or anti-cancer effects. Nutraceuticals include flavonoids and carotenoids in fruits and vegetables, for example.

This project, supported by the U.S. Department of Agriculture's National Institute of Food and Agriculture, will focus on manipulating the structure and composition of nano-emulsion delivery systems to modify the fate of encapsulated nutraceuticals in the GI tract to enhance their bioavailability.

"In the last decade, knowledge has been advancing about how to effectively deliver beneficial components in food. This research will allow us to direct the assembly of nano-emulsion droplets to create characteristics that will dictate how they are digested and absorbed," Xiao explains. "This would be a model for nutraceutical delivery in a wide range of food products. Someday prepared foods may help lower our risk of cancer, for example."

Specifically, using both cell culture and animal models, Xiao and colleagues will design lipid nanoparticles at three stages: From nano-emulsion droplets containing nutraceuticals, to mixed micelles and finally to chylomicrons. To start this process, digestion physiochemically disassembles nano-emulsion droplets. The resulting chemical components are then assembled into mixed micelles in the small intestine, where epithelial cells called enterocytes take them up. There they are reassembled into chylomicrons and absorbed into blood circulation through the lymph system.

The scientists want to influence the size and composition of chylomicrons, because these characteristics dictate the fate of nutraceuticals encapsulated in the chylomicrons. Certain sizes and compositions are better able to deliver nutraceuticals to the lymph system, which protects nutraceuticals from being cleared by the liver. This will enhance bioavailability of flavonoids and other beneficial compounds to the body, potentially offering health benefits.

"We're basically utilizing what already happens in our bodies all the time, but introducing food-grade nano-emulsion systems that can influence the nature of mixed micelles as well as chylomicrons," says Xiao. "It's safe, it's all digested and simply delivers beneficial food components to a greater extent than if the system was left alone."

Xiao, a specialist in how food components interact with biochemical processes in the GI tract, will work with UMass Amherst colleagues including Julian McClements, an expert in the design of nano-scale delivery systems, and Eric Decker, an expert in food chemistry. This team is among the world's most accomplished groups at using food-grade delivery systems to enhance health benefits of food components.


'/>"/>
Contact: Janet Lathrop
jlathrop@admin.umass.edu
413-545-0444
University of Massachusetts at Amherst
Source:Eurekalert  

Related medicine news :

1. 123Greetings.com Launches German Ecards Under World Languages Category, Enhancing Its Portfolio Of Multilingual Greetings
2. PolyU Develops Anti-Counterfeiting Ink for Enhancing Product Authenticity and Traceability
3. The Secret to Revealing and Enhancing Younger-Looking Skin from Sublime Beauty
4. Enhancing RNA interference
5. Enhancing Compatibility and Boosting Performance; NEXCOM Introduces the ICES 670 COM Express Module Based on 4th Generation Intel® Core™ Processor
6. Research Suggests that Lack of Exercise Drive is Genetic, Making Energy Enhancing Supplements Like Prescopodene Beneficial For Sticking to Your Exercise Routine
7. NYU and NYU Langone researchers devise method for enhancing CEST MRI
8. Researchers identify new pathway, enhancing tamoxifen to tame aggressive breast cancer
9. BOMI International and Transwestern Partner to Offer Property and Facility Staff Skill-Enhancing Education Programs
10. Continuing Education Provider HomeCEUConnection.com Adds New Career Enhancing Video Courses to Online Catalog
11. Delray Recovery Center Treats Steroid and Performance Enhancing Drug Abuse
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Enhancing bioavailability of healthful components in food using nanoparticle design
(Date:7/21/2017)... ... , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh in Abilene, Texas, has ... solve problems and pleads with world leaders to be more open about positive changes. Yisrayl ... He says there is a peaceful and positive way to solve all; yes, all issues, ...
(Date:7/21/2017)... ... 21, 2017 , ... “Kids aren't born knowing how to regulate their emotions ... Tucker, Founder of St. Louis-based positive education company Generation Mindful. To help with that ... July 21st. , The kit uses colorful, engaging and educational illustrations and games ...
(Date:7/21/2017)... TORONTO, ONTARIO, CANADA (PRWEB) , ... July 21, ... ... with over 80% follow-up at 10 years, researchers from the Multicenter Orthopaedics Outcome ... knee-related quality of life a decade after surgery, though activity levels decline over ...
(Date:7/20/2017)... Viejo, CA (PRWEB) , ... July 20, 2017 , ... ... when placed between two clips in the FCPX timeline. This effect isolates horizontal and ... transition in this package contains either a rotating or flipping animation and can be ...
(Date:7/20/2017)... July 20, 2017 (PRWEB) , ... ... ... Technologies, a global provider of enterprise-grade IT operations analytics and application performance ... of one of world’s largest healthcare services providers. , According to Peter ...
Breaking Medicine News(10 mins):
(Date:7/10/2017)... 2017  BDI Group subsidiary Pathway Purchasing Network, ... organization serving specialty pharmacies, home infusion companies and ... significant, value-added member programs designed to help organizations ... and improve access and affordability for patients who ... Pathway has worked ...
(Date:7/6/2017)... -- ThriveRx, the nutrition division of Diplomat Specialty Infusion Group, is celebrating ... support. To celebrate its anniversary, ThriveRx recently launched a redesigned ... look with improved organization to create the best user experience for consumers ... ... "We,ve made several great strides throughout ...
(Date:7/5/2017)... July 5, 2017 Pace Analytical, a company of over 2,000 employees ... they have acquired ESC Lab Sciences, further solidifying their position as the top ... . ... President and CEO of Pace Analytical ... Sciences out of Mt Juliet, TN , enhances Pace Analytical,s ...
Breaking Medicine Technology: