Navigation Links
Enhancing bioavailability of healthful components in food using nanoparticle design

AMHERST, Mass. - Food scientist Hang Xiao of the University of Massachusetts Amherst recently received a four-year, $491,220 grant to study the biochemical fate of nanoemulsion-based food delivery systems in the gastrointestinal (GI) tract, hoping to re-shape them and enhance the absorption of beneficial food components encapsulated in delivery systems.

Food biochemists like Xiao believe that if taken up in appropriate amounts and forms, certain food components known as nutraceuticals might benefit human health by providing anti-inflammatory or anti-cancer effects. Nutraceuticals include flavonoids and carotenoids in fruits and vegetables, for example.

This project, supported by the U.S. Department of Agriculture's National Institute of Food and Agriculture, will focus on manipulating the structure and composition of nano-emulsion delivery systems to modify the fate of encapsulated nutraceuticals in the GI tract to enhance their bioavailability.

"In the last decade, knowledge has been advancing about how to effectively deliver beneficial components in food. This research will allow us to direct the assembly of nano-emulsion droplets to create characteristics that will dictate how they are digested and absorbed," Xiao explains. "This would be a model for nutraceutical delivery in a wide range of food products. Someday prepared foods may help lower our risk of cancer, for example."

Specifically, using both cell culture and animal models, Xiao and colleagues will design lipid nanoparticles at three stages: From nano-emulsion droplets containing nutraceuticals, to mixed micelles and finally to chylomicrons. To start this process, digestion physiochemically disassembles nano-emulsion droplets. The resulting chemical components are then assembled into mixed micelles in the small intestine, where epithelial cells called enterocytes take them up. There they are reassembled into chylomicrons and absorbed into blood circulation through the lymph system.

The scientists want to influence the size and composition of chylomicrons, because these characteristics dictate the fate of nutraceuticals encapsulated in the chylomicrons. Certain sizes and compositions are better able to deliver nutraceuticals to the lymph system, which protects nutraceuticals from being cleared by the liver. This will enhance bioavailability of flavonoids and other beneficial compounds to the body, potentially offering health benefits.

"We're basically utilizing what already happens in our bodies all the time, but introducing food-grade nano-emulsion systems that can influence the nature of mixed micelles as well as chylomicrons," says Xiao. "It's safe, it's all digested and simply delivers beneficial food components to a greater extent than if the system was left alone."

Xiao, a specialist in how food components interact with biochemical processes in the GI tract, will work with UMass Amherst colleagues including Julian McClements, an expert in the design of nano-scale delivery systems, and Eric Decker, an expert in food chemistry. This team is among the world's most accomplished groups at using food-grade delivery systems to enhance health benefits of food components.

Contact: Janet Lathrop
University of Massachusetts at Amherst

Related medicine news :

1. Launches German Ecards Under World Languages Category, Enhancing Its Portfolio Of Multilingual Greetings
2. PolyU Develops Anti-Counterfeiting Ink for Enhancing Product Authenticity and Traceability
3. The Secret to Revealing and Enhancing Younger-Looking Skin from Sublime Beauty
4. Enhancing RNA interference
5. Enhancing Compatibility and Boosting Performance; NEXCOM Introduces the ICES 670 COM Express Module Based on 4th Generation Intel® Core™ Processor
6. Research Suggests that Lack of Exercise Drive is Genetic, Making Energy Enhancing Supplements Like Prescopodene Beneficial For Sticking to Your Exercise Routine
7. NYU and NYU Langone researchers devise method for enhancing CEST MRI
8. Researchers identify new pathway, enhancing tamoxifen to tame aggressive breast cancer
9. BOMI International and Transwestern Partner to Offer Property and Facility Staff Skill-Enhancing Education Programs
10. Continuing Education Provider Adds New Career Enhancing Video Courses to Online Catalog
11. Delray Recovery Center Treats Steroid and Performance Enhancing Drug Abuse
Post Your Comments:
Related Image:
Enhancing bioavailability of healthful components in food using nanoparticle design
(Date:6/24/2016)... ... ... was in a crisis. Her son James, eight, was out of control. Prone to extreme ... “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If there was ... other children and say he was going to kill them. If we were driving ...
(Date:6/24/2016)... Francisco, CA (PRWEB) , ... June 24, 2016 ... ... CitiDent, is now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive ... self-ligating Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation ...
(Date:6/24/2016)... Plano, TX (PRWEB) , ... June 24, 2016 , ... ... taking part in Genome magazine’s Code Talker Award, an essay contest in which patients ... for an award to be presented at the 2016 National Society of Genetic Counselors ...
(Date:6/24/2016)... Vegas, Nevada (PRWEB) , ... June 24, 2016 ... ... Las Vegas client, The Grove Investment Group (TGIG), has initiated cultivation and processing ... Grove, in Las Vegas and Pahrump, Nevada. , Puradigm is the manufacturer of ...
(Date:6/24/2016)... ... 2016 , ... Venture Construction Group (VCG) sponsors Luke’s Wings ... at the Woodmont Country Club at 1201 Rockville Pike, Rockville, Maryland, 20852. The ... members that have been wounded in battle and their families. Venture Construction Group is ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 23, 2016  MedSource announced today that it ... software solution of choice.  This latest decision demonstrates ... to their clients by offering a state-of-the-art electronic ... establishes nowEDC as the EDC platform of choice ... clients.  "nowEDC has long been a preferred EDC ...
(Date:6/23/2016)... Any dentist who has made an implant supported ... Many of them do not even offer this as a ... laboratory costs involved. And those who ARE able to offer ... high cost that the majority of today,s patients would not ... Zadeh , founder of Dental Evolutions Inc. and inventor of ...
(Date:6/23/2016)... , June 23, 2016  In a startling report released today, ... their residents by lacking a comprehensive, proven plan to eliminate prescription ... definitive ranking of how states are tackling the worst drug crisis ... four states – Kentucky , New ... Vermont . Of the 28 failing states, three – ...
Breaking Medicine Technology: