Navigation Links
Enhanced white blood cells heal mice with MS-like disease

Madison, Wis. Genetically engineered immune cells seem to promote healing in mice infected with a neurological disease similar to multiple sclerosis (MS), cleaning up lesions and allowing the mice to regain use of their legs and tails.

The new finding, by a team of University of Wisconsin School of Medicine and Public Health researchers, suggests that immune cells could be engineered to create a new type of treatment for people with MS.

Currently, there are few good medications for MS, an autoimmune inflammatory disease that affects some 400,000 people in the United States, and none that reverse progress of the disease.

Dr. Michael Carrithers, assistant professor of neurology, led a team that created a specially designed macrophage an immune cell whose name means "big eater." Macrophages rush to the site of an injury or infection, to destroy bacteria and viruses and clear away damaged tissue. The research team added a human gene to the mouse immune cell, creating a macrophage that expressed a sodium channel called NaVI.5, which seems to enhance the cell's immune response.

But because macrophages can also be part of the autoimmune response that damages the protective covering (myelin) of the nerves in people with MS, scientists weren't sure whether the NaV1.5 macrophages would help or make the disease worse.

When the mice developed experimental autoimmune encephalomyelitis the mouse version of MS -- they found that the NaV1.5 macrophages sought out the lesions caused by the disease and promoted recovery.

"This finding was unexpected because we weren't sure how much damage they would do, versus how much cleaning up they would do,'' Carrithers says. "Some people thought the mice would get more ill, but we found that it protected them and they either had no disease or a very mild case."

In follow-up experiments, regular mice that do not express the human gene were treated with the NaV1.5 macrophages after the onset of symptoms, which include weakness of the back and front limbs. The majority of these mice developed complete paralysis of their hindlimbs. Almost all of the mice that were treated with the Na1.5 macrophages regained the ability to walk. Mice treated with placebo solution or regular mouse macrophages that did not have NaV1.5 did not show any recovery or became more ill. In treated mice, the research team also found the NaV1.5 macrophages at the site of the lesions, and found smaller lesions and less damaged tissue in the treated mice.

Because the NaV1.5 variation is present in human immune cells, Carrithers says, "The questions are, 'Why are these repair mechanisms deficient in patients with MS and what can we do to enhance them?' '' He says the long-range goal is to develop the NaV1.5 enhanced macrophages as a treatment for people with MS.

Carrithers is a neurologist who treats patients with multiple sclerosis at University of Wisconsin Hospital and Clinics and the William S. Middleton Veterans' Hospital in Madison. His research team includes Kusha Rahgozar, Erik Wright and Lisette Carrithers. The research was supported by a prior National MS Society research grant and a current VA Merit Award from the Biomedical Laboratory Research and Development service of the Department of Veterans Affairs (7784115).

The study is being published in the June issue of the Journal of Neuropathology and Experimental Neurology.


Contact: Susan Lampert Smith
University of Wisconsin-Madison

Related medicine news :

1. SAGES Welcomes New President, Dr. Gerald M. Fried - Surgical Education, Quality of Care and Enhanced Patient Recovery to be Top Priorities
2. Turmeric Products Are Not All Alike, Christian Wilde's Newly Released, Enhanced Turmeric+ Formula (with 7 Additional Synergizing Ingredients) Is a Totally Unique.
3. ParentMagic Inc Releases Enhanced E-Book “Surviving Your Adolescents” Available in iBooks on iOS
4. Inflammatory bowel disease detection enhanced with PET/CT
5. Altec, Premier Document Management Solution Provider, Releases doc-link 3.0 Providing Greater Mobility and Enhanced Usability
6. BroadConnect Leads the Charge in Ethernet Connectivity, Thanks to Release of Enhanced Ethernet Service
7. New QuickMedical Facility Offers More Products and Enhanced Service
8. New centers will lead to enhanced geriatric social work training
9. Telcom & Data Introduces Scitec Disposable Hospital Phones for Enhanced Disease Control
10. Enhanced Microsoft SharePoint 2013 and Microsoft Office 365 Support Highlights Release of AvePoint’s DocAve 6 Service Pack 2
11. Plastics Color Corp. Announces Phase II of Its isaac™ Web Portal: Enhanced Visualizer Supports Color Design and Development
Post Your Comments:
(Date:11/25/2015)... ... November 25, 2015 , ... ... I found that regular bras were incredibly uncomfortable," said an inventor from Bronx, ... bra." , She developed the patent-pending RECOVERY BRA for added comfort and support. ...
(Date:11/25/2015)... ... November 25, 2015 , ... An unlikely combination of recycled ... way for homeless people to have a more dignified and comfortable night’s sleep. ... they are repurposing plastic bags into sleeping mats for the homeless. The ...
(Date:11/25/2015)... CHICAGO, IL (PRWEB) , ... November 25, 2015 ... ... the cure for Tuberous Sclerosis Complex (TSC), as well as raising public awareness ... people where they need it—presented a third donation of $35,000 to bolster progress ...
(Date:11/25/2015)... ... November 25, 2015 , ... Students and parents have something ... winners of the Create Real Impact awards. California Casualty is proud to ... the tide of distracted and reckless driving, the number one killer of young drivers. ...
(Date:11/24/2015)... ... November 25, 2015 , ... Genesis Chiropractic ... Plan software creates an agreement between the practice owner and the patient that ... monitoring, notification, and projections. Click here to learn more. ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... , Nov. 24, 2015  Array BioPharma ... its Chief Executive Officer, Ron Squarer , ... Conference in New York.  The public is welcome ... on the Array BioPharma website.Event:Piper Jaffray Annual Healthcare ... Wednesday, December 2, 2015Time:1:30 p.m. Eastern Time Webcast: ...
(Date:11/24/2015)... 24. November 2015 Avery Biomedical ... Systems, ist erfreut, die Berufung von Anders ... geben zu können. ... --> Foto -   ... Von 1984-1986 war er Fellow des Cardiovascular ...
(Date:11/24/2015)... Nov. 24, 2015 Avery Biomedical Devices (ABD), ... to announce the appointment of Anders Jonzon , ... Dr. Jonzon is a ... Children,s Hospital, Uppsala University, Uppsala and Children,s Hospital, Karolinska, ... was a fellow at the Cardiovascular Institute (UCSF). His ...
Breaking Medicine Technology: