Navigation Links
Enhanced skin cancer risk linked to defects in cellular aging controls
Date:2/22/2009

February 23, 2009, Cambridge, UK Cell lifespan is limited by telomeres, DNA sequences that cap chromosomes and control the number of times a cell may be copied. A new study reported in Disease Models & Mechanisms (DMM), dmm.biologists.org, describes how telomere dysfunction in skin cells can lead to increased skin cancer risk and pigmentation.

Researchers from Spain investigated the molecular mechanisms underlying skin cell telomere dysfunction using a mouse model of Xeroderma Pigmentosum (XP), a disease in which patients have increased sensitivity to ultraviolet (UV) radiation. Their studies revealed that these mice have impaired skin cell regeneration, and that limiting the activity of a tumor suppressor signaling protein, p53, restores cell regeneration and reduces hyperpigmentation. Surprisingly, limiting p53 activity also advances the progression of skin cancers.

This study establishes a link between telomere dysfunction, cancer progression and the dysfunction of DNA repair mechanisms in XP patients. Understanding the pathways which control cell regeneration and cancer progression in these patients will not only aid in treatments for XP patients, but can likewise provide clues on how to target and better treat other cases of skin cancer.


'/>"/>

Contact: Donna Perry
donna@biologists.com
44-122-343-3319
The Company of Biologists
Source:Eurekalert

Page: 1

Related medicine news :

1. EDAP Launches Enhanced Communication Plans at SIU Paris Congress
2. Enhanced PrecyseCode 2X(TM) Further Accelerates Remote Coding and Improves Cash Flow for Hospitals
3. Joint Juice Launches New Ready-to-Drink Glucosamine & Vitamin-Enhanced Dietary Supplement Water Nationwide
4. The American Pain Foundation (APF) and The HealthCentral Network Collaborate to Develop Enhanced Internet Resources for People with Pain
5. PreViser Launches New Website and Enhanced Version of Its Oral Disease and Risk Assessment Software
6. NHP Reports Third Quarter 2007 Revenue and FFO Growth and Enhanced Disclosure Information
7. Brookdale Senior Living Announces Enhanced Web Site
8. T cell immunity enhanced by timing of interleukin-7 therapy
9. The HealthCentral Network and Sister to Sister Form Alliance to Develop Enhanced Online Resources
10. Transitions Optical Promotes Healthy Sight Through a Nationwide Integrated Advertising Campaign and the Launch of an Enhanced Consumer Web Site
11. Enhanced U.S. Efforts to Fight Tropical Disease Offer Hope to Millions of Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... (PRWEB) , ... April 28, 2016 , ... Metabolic ... supplement GlycoLoad at this week’s 2016 Europa Games Get Fit and Sports Expo ... consumers alike, the Europa Orlando Expo coming up April 29-30, was selected as the ...
(Date:4/28/2016)... ... ... The Aging in Motion Coalition (AIM) has announced the Centers for ... recognition for separate reporting and data collection. The code, M62.84, will be available for ... a combination of low muscle mass and weakness in older adults that causes functional ...
(Date:4/28/2016)... ... April 28, 2016 , ... Prescription ... co-operative bankruptcy to receive their prescription medications through America’s fastest-growing pharmacy program. ... medications from over 180 American pharmaceutical companies for $35 per month, per ...
(Date:4/28/2016)... ... April 28, 2016 , ... ... latest offering, the Protocol Calendar Exchange , is officially open to all ... protocol calendars available for sites to download into their clinical trial management system ...
(Date:4/28/2016)... ... April 28, 2016 , ... ... Medical Officer at the Steadman Philippon Research Institute in Vail, Colorado, attended the ... raise awareness about the debilitating and costly musculoskeletal disorders that are affecting millions ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... , April 28, 2016 ... insights on healthcare, announced today that it has been ... Cool Vendor in Life Sciences, 2016, ... 2016.  The report focuses on life-science- oriented analytics, algorithms ... from patients and doctors, confirm medication ingestion, and analyze ...
(Date:4/28/2016)... FREMONT, Calif. , April 28, 2016 ... Enterprise Validation Lifecycle Management Solutions (VLMS) today ... products and services for sufferers of chronic ... management System to manage their corporate validation ... been seeking a software solution to manage ...
(Date:4/27/2016)... 27 Avril 2016   ... de +5% sur le trimestre, soutenu par une ... Croissance de +16% des ventes aux ... Mauna Kea Technologies (Euronext : MKEA, FR0010609263 ; OTCQX : MKEAY), ... annonce aujourd,hui son chiffre d,affaires pour le premier ...
Breaking Medicine Technology: