Navigation Links
Enhanced cord blood stem cell transplants safe in long-term studies
Date:4/18/2011

BOSTON--An innovative experimental treatment for boosting the effectiveness of stem-cell transplants with umbilical cord blood has a favorable safety profile in long-term animal studies, report scientists from Dana-Farber Cancer Institute, Beth Israel Deaconess Medical Center (BIDMC), and Children's Hospital Boston (CHB).

Analysis of long-term safety testing in nonhuman primates, published online by the journal Cell Stem Cell, revealed that, after one year following transplant, umbilical cord blood units treated with a signaling molecule called 16,16-dimethyl PGE2 reconstituted all the normal types of blood cells, and none of the animals receiving treated cord blood units developed cancer. Wolfram Goessling, MD, PhD, of Dana-Farber and Brigham and Women's Hospital, is the first author of the paper, and Trista North, PhD, of BIDMC is the senior author.

The results of long-term safety studies in mice were previously submitted to the Food and Drug Administration to gain permission for a Phase 1 clinical trial under an Investigational New Drug (IND) application. Principal investigator, Corey Cutler, MD, a Dana-Farber transplant specialist, initiated the trial in 2009 at Dana-Farber and the Massachusetts General Hospital. The IND is sponsored by Fate Therapeutics, Inc. of San Diego.

Goessling and North were post-doctoral fellows in the laboratory of co-author Leonard Zon, MD, a stem cell researcher at CHB and a scientific founder of Fate Therapeutics, when they hit upon 16,16-dimethyl PGE2 while looking for compounds that could regulate the production of hematopoietic stem cells. The initial testing made use of zebra fish models. Goessling commented that "this is the first time a compound discovered in zebra fish has received a nod from the FDA for a clinical trial."

One of the limitations of cord blood as a transplant source is the cells engraft, or "take," in the recipient's bone marrow more slowly than matched donor cells form bone marrow. In addition, there is a higher failure rate for cord blood transplants. Thus there is a need for ways to improve the speed and quality of cord blood transplantation.


'/>"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
Source:Eurekalert  

Related medicine news :

1. Efficacy of tuberculosis vaccine enhanced
2. Enhanced early childhood education pays long-term dividends in better health
3. More lives saved with 24/7 enhanced staffing in medical ICU
4. My1Stop.com Improves Customer Experience with Enhanced Online Printing Web Site Design
5. Horizon Display Demonstrates their Dedication to After-Sales Support with Enhanced Online Resources
6. Orion Health Helps Northumbria Healthcare NHS Foundation Trust Deliver an Enhanced Electronic Patient Record
7. Provalis Research Announces the Release of WordStat 6, Delivering Enhanced Analytical and Visualization Tools for Textual Data
8. 1Dental.com Announces Enhanced Broker-Affiliate Program
9. SumNuts Vitamin Nuts Launched, Enhanced with Vitamin D3 and Calcium
10. DST Health Solutions Releases Enhanced ACG System to Help Health Plans Improve Member Health
11. Acuo Technologies Announces Enhanced Offerings That Facilitate Management of Non-DICOM Objects
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Enhanced cord blood stem cell transplants safe in long-term studies
(Date:6/23/2017)... ... June 23, 2017 , ... Radabaugh ... planning to families and business owners in North Central West Virginia, is embarking ... services to differently abled residents in the region. , The Stepping Stones organization ...
(Date:6/22/2017)... ... ... Groove Ring is excited to announce they've partnered with Olympic runner Jared ... all-purpose rings. Whether you’re an athlete, adventurer, professional, or love to venture the great ... the rock face to the auto shop, Groove Ring is the world's first breathable ...
(Date:6/22/2017)... (PRWEB) , ... June 22, 2017 , ... A June ... Rittenberg to a correspondent concerned about an apparent lack of oral hygiene by an ... specializes in geriatrics and dementia-related matters, suggests a number of steps, including scheduling a ...
(Date:6/20/2017)... ... ... of negotiations, FaceCradle USA is proud to announce the debut of FaceCradle travel pillow ... on QVC is something we all worked hard to achieve for many months, and represents ... homes in the United States,” said FaceCradle USA President Dylan Doherty. “We can’t wait to ...
(Date:6/20/2017)... ... June 20, 2017 , ... EdChoice ... introduction of school choice can promote economic development in economically distressed urban areas. ... according to the report, contributed to the economic development of the city of ...
Breaking Medicine News(10 mins):
(Date:6/1/2017)... June 1, 2017 Nutriceutical Holdings (NH), parent ... Solutions (VRS), and KD Pharma Group have decided to ... by KD Pharma Group. KD Pharma Group will become ... to acquire the entire company. "We believe ... are committed to growing the NH companies by providing ...
(Date:5/30/2017)... , May 30, 2017 Hill-Rom Holdings, Inc. ... Annual Global Healthcare Conference on Tuesday, June 13, 2017, ... John Greisch , Hill-Rom,s president and chief executive officer, is ... The live audio webcast can be accessed at http://ir.hill-rom.com/events.cfm ... conclusion of the live event through September 13, 2017. ...
(Date:5/29/2017)... -- Cellect Biotechnology Ltd. (NASDAQ: APOP ; TASE: APOP), ... selection of stem cells, today provided a corporate update ... March 31 st , 2017. "We ... quarter of 2017," said Dr. Shai Yarkoni, Chief Executive ... of the first blood cancer patient in the recently ...
Breaking Medicine Technology: