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Engineers use blood's hydrodynamics to manipulate stem, cancer cells
Date:1/23/2008

neutrophil rolling in his office one day when Jane Liesveld, a hematology clinician doing work on bone marrow stem cells at the University of Rochester, walked by and noticed a poster of Kings work in the hallway outside his office.

She dropped in and said, I have a pretty plentiful source of primary stem cells from patients. Can you think of any biophysical research to do with that" says King. The stem cell angle just fell from the sky.

As King worked with Liesveld he found that the basic rolling mechanism was the foundation of a number of other processes, including stem cell transplantationa natural phenomenon where stem cells move in and out of bone tissue via the blood. In 2004, he found that he could coat a material with specific adhesive selectins and capture living stem cells. This collaboration resulted in two human stem cell papers published just within the last month: in Biotechnology Progress (Charles et al., 2007) and Clinical Chemistry (Narasipura et al., 2007).

In the new British Journal of Haematology paper, King and colleagues show they can take the process a step further by implanting the device in a living rat with the selectin coating remaining active for 1-2 hours. When the tube was removed, King found hed indeed captured cells straight out of the bloodstream, including contaminantsnon-stem cellsas expected. What he didnt expect was how many of the cells were viable stem cells.

I was astounded, says King. More than 25 percent of the sample was stem cells. Its amazing because even when you use drugs to increase the number of free stem cells in the blood, they still only make up less than 1 percent of all cells. If you use traditional methods to collect stem cells, centrifuging the rats blood, even in these drug-treated rats you might get 3 or 4 percent stem cellsmeaning only 3 or 4 percent of the cells you obtain are stem cells.

King points out that centrifugal methods currently produce an overall higher stem cell yield becaus
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Contact: Jonathan Sherwood
jonathan.sherwood@rochester.edu
585-273-4726
University of Rochester
Source:Eurekalert

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