Navigation Links
Engineers use blood's hydrodynamics to manipulate stem, cancer cells
Date:1/23/2008

neutrophil rolling in his office one day when Jane Liesveld, a hematology clinician doing work on bone marrow stem cells at the University of Rochester, walked by and noticed a poster of Kings work in the hallway outside his office.

She dropped in and said, I have a pretty plentiful source of primary stem cells from patients. Can you think of any biophysical research to do with that" says King. The stem cell angle just fell from the sky.

As King worked with Liesveld he found that the basic rolling mechanism was the foundation of a number of other processes, including stem cell transplantationa natural phenomenon where stem cells move in and out of bone tissue via the blood. In 2004, he found that he could coat a material with specific adhesive selectins and capture living stem cells. This collaboration resulted in two human stem cell papers published just within the last month: in Biotechnology Progress (Charles et al., 2007) and Clinical Chemistry (Narasipura et al., 2007).

In the new British Journal of Haematology paper, King and colleagues show they can take the process a step further by implanting the device in a living rat with the selectin coating remaining active for 1-2 hours. When the tube was removed, King found hed indeed captured cells straight out of the bloodstream, including contaminantsnon-stem cellsas expected. What he didnt expect was how many of the cells were viable stem cells.

I was astounded, says King. More than 25 percent of the sample was stem cells. Its amazing because even when you use drugs to increase the number of free stem cells in the blood, they still only make up less than 1 percent of all cells. If you use traditional methods to collect stem cells, centrifuging the rats blood, even in these drug-treated rats you might get 3 or 4 percent stem cellsmeaning only 3 or 4 percent of the cells you obtain are stem cells.

King points out that centrifugal methods currently produce an overall higher stem cell yield becaus
'/>"/>

Contact: Jonathan Sherwood
jonathan.sherwood@rochester.edu
585-273-4726
University of Rochester
Source:Eurekalert

1

GOOD

Page: 1 2 3

Related medicine news :

1. Engineers developing new cements to heal spinal fractures
2. SMRT Architects and Engineers Selected to Design New $115M Digital X-Ray Manufacturing Facility for GE Healthcare
3. Microchip-based device can detect rare tumor cells in bloodstream
4. Microchip Spots Stray Tumor Cells in the Bloodstream
5. CoolTouch Introduces CoolLipo(TM) Laser System, Recently FDA Cleared for Laser-Assisted Lipolysis
6. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
7. Survival differences by race most apparent in advanced stages of breast cancer
8. MRI finds breast cancer before it becomes dangerous
9. Investigators uncover intriguing clues to why persistent acid reflux sometimes turns into cancer
10. Pathway links inflammation, angiogenesis and breast cancer
11. Radiologists encouraged to look beyond cancer for clinically unseen diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2009)... dementia risk, research finds , , TUESDAY, Dec. 15 (HealthDay ... that regulates appetite, may guard against Alzheimer,s disease, new ... this may be one of many agents that we ... senior study author Dr. Sudha Seshadri, an associate professor ... it may be one of many markers that we ...
(Date:12/15/2009)... education program will train advocates to be leaders ... Project developed with support from experts in online ... ,, WASHINGTON, Dec. 15 ... are accepting applications for the first-ever "Malaria Griots" ... and educate participants to become leaders in the ...
(Date:12/15/2009)... NEW YORK, Dec. 15 The following are ... Attorney General for the criminal division, at the ... you, Secretary Sebelius. And thank you for the ... the HEAT initiative. ,, Together, our Departments ... lasting results. ,, We,ve made tremendous progress in ...
(Date:12/15/2009)... Mich. A new study links chronic obstructive pulmonary ... act as sentinels to activate the body,s immune system. ... research adds to growing awareness of the immune system,s ... affects more than 12 million Americans with wheezing, shortness ... factors is key if doctors are to find better ...
(Date:12/15/2009)... that phthalates actually cause the condition, experts ... Common chemicals found in plastic toys and elsewhere ... in boys, preliminary research suggests. , The ... pediatricians, adds fuel to the debate over these ... by some scientists. The chemical industry claims the ...
Breaking Medicine News(10 mins):Health News:Fat Hormone May Protect Against Alzheimer's 2Health News:Fat Hormone May Protect Against Alzheimer's 3Health News:ONE and Malaria No More Launch 'Malaria Griots' 2Health News:ONE and Malaria No More Launch 'Malaria Griots' 3Health News:ONE and Malaria No More Launch 'Malaria Griots' 4Health News:Remarks by Lanny A. Breuer, Assistant Attorney General for the Criminal Division, at the Medicare Fraud Strike Force Press Conference 2Health News:Remarks by Lanny A. Breuer, Assistant Attorney General for the Criminal Division, at the Medicare Fraud Strike Force Press Conference 3Health News:Immune cell activity linked to worsening COPD 2Health News:Immune cell activity linked to worsening COPD 3Health News:Breast Growth in Boys Might Be Linked to Plastics Chemical 2Health News:Breast Growth in Boys Might Be Linked to Plastics Chemical 3
... 13, 2008 Five neonatology fellows have been ... in the area of follow-up care of the ... The grants, which underscore MedImmune,s commitment to expanding ... institution a $35,000 grant, totaling $175,000 in research ...
... Fall Should Not Pose Setback and Expects the 89-Year-Old ... Evangelist to Recover ... to his mountain home in Montreat, N.C. upon his release this,afternoon ... admitted for observation after he tripped over one of his three ...
... form of disease by 20 years after operation, study ... transplant patients have a higher incidence of cancer than ... In a new study published in the October issue ... risk pattern in 540 Finnish liver transplant recipients from ...
... Oct. 10 Do you think that the blind,can,t ... the October,17 open house at the Virginia Rehabilitation Center ... there empower the blind and,visually impaired to lead productive, ... The center, located at 401 Azalea Avenue, is holding ...
... Life Sciences Inc.,(NuView) has agreed to assume management ... the linear accelerator and cyclotron,production facilities in Denton, ... Iodine-123 and Thallium-201 used in,molecular imaging and nuclear ... "We are confident that by improving operational,efficiencies at ...
... blame , , FRIDAY, Oct. 10 (HealthDay News) -- In a ... associated with a higher death rate, according to a new ... the Journal of General Internal Medicine , researchers from ... of 75.6 years) who had diabetes and were enrolled in ...
Other Medicine News:Health News:MedImmune grants 5 new fellowships to help expand premature infant follow-up care research 2Health News:Billy Graham Returns Home Following Hospital Observation 2Health News:Liver Transplant Patients at Higher Cancer Risk 2Health News:Virginia Rehabilitation Center for the Blind and Vision Impaired Celebrates Opening of New Student Dormitory 2Health News:Older Diabetics With Depression Face Higher Death Rate 2
(Date:12/15/2009)... -- Reportlinker.com announces that a new ... its catalogue: ,, Systemic Lupus ... Market Forecasts to 2015 ,, ... Lupus Erythematosus - Drug Pipeline Analysis ... Summary ,, GlobalData, the ...
(Date:12/15/2009)... HA,AYIN, Israel, December 15 EnzySurge ... the advanced chronic,wound management market, announced today ... Food and Drug Administration (FDA) to market ... FDA also cleared,DermaSept, an Over-the-Counter version of ... EnzySurge is the developer of the ...
(Date:12/15/2009)... Dec. 15 NxStage Medical, Inc. (Nasdaq: ... dialysis products, today announced that a group of ... be embarking on a week-long, conventional (non-dialysis) Caribbean ... The cruise, dubbed the "2010 Freedom Cruise: We,re ... Fla. on January 3, 2010 and returns on ...
Breaking Medicine Technology:Reportlinker Adds Systemic Lupus Erythematosus - Drug Pipeline Analysis and Market Forecasts to 2015 2Reportlinker Adds Systemic Lupus Erythematosus - Drug Pipeline Analysis and Market Forecasts to 2015 3Reportlinker Adds Systemic Lupus Erythematosus - Drug Pipeline Analysis and Market Forecasts to 2015 4Reportlinker Adds Systemic Lupus Erythematosus - Drug Pipeline Analysis and Market Forecasts to 2015 5Reportlinker Adds Systemic Lupus Erythematosus - Drug Pipeline Analysis and Market Forecasts to 2015 6Reportlinker Adds Systemic Lupus Erythematosus - Drug Pipeline Analysis and Market Forecasts to 2015 7Reportlinker Adds Systemic Lupus Erythematosus - Drug Pipeline Analysis and Market Forecasts to 2015 8EnzySurge Receives FDA Approval for SilverStream(TM) Innovative Wound Management Solution 2Group of NxStage(R) Home Hemodialysis Patients to Take Caribbean Cruise with the System One(TM) 2Group of NxStage(R) Home Hemodialysis Patients to Take Caribbean Cruise with the System One(TM) 3Group of NxStage(R) Home Hemodialysis Patients to Take Caribbean Cruise with the System One(TM) 4Study shows family caregivers simple touch techniques reduce symptoms in cancer patients 61568 1Study shows family caregivers simple touch techniques reduce symptoms in cancer patients 61568 2Oscar Pistorius artificial limbs give him clear major advantage for sprint running 10776 1Oscar Pistorius artificial limbs give him clear major advantage for sprint running 10776 2Oscar Pistorius artificial limbs give him clear major advantage for sprint running 10776 3Benefits of Eating Fish May Depend on Preparation 61563 1Benefits of Eating Fish May Depend on Preparation 61563 2
Chemically Resistant Sealing Mat for 384ch, Square Well Available Sterile...
Silicone Compression Mat, Bulk...
... Alpha unit, these new pads may be used in ... runs may be sealed with the same pad. ... a microplate from sticking to the block and lid, ... sealing performance, which means you can use as little ...
Easy to pierce, remove using foil stripper...
Medicine Products: