Navigation Links
Engineers use blood's hydrodynamics to manipulate stem, cancer cells
Date:1/23/2008

A tiny, implantable device has pulled adult stem cells out of a living rat with a far greater purity than any present technique.

The test of the device designed by Michael R. King, associate professor of biomedical engineering at the University of Rochester, will be reported in the March 3 issue of the British Journal of Haematology.

Its the kind of research that, before we tried it, we never would have expected such a remarkable result straight out of the gate, says King. Were finding we can play off the hydrodynamics of moving blood to isolate and manipulate specific cell populations with great efficiency.

King is at the forefront of a new field; manipulating stem cells, white blood cells, and even cancer cells by exploiting the mechanics of the cells movement with such precision that he is having success capturing and even reprogramming several cell types as they pass through the device, he says.

A chance encounter between an engineer and a hematology clinician gave rise to the field in 2002.

King was studying how certain white blood cells, called neutrophils, know how to migrate to a point of infection. He observed how, near an injury site, the walls of the nearby blood vessels expressed an adhesive protein called a selectin, and if passing neutrophils brushed against these selectins, they stuck to the vessel wall.

But the cells did not remain stuckthey rolled. With a precise balance between the adhesion of the selectins and the forces of the flowing bloodstream, the cells could move much more slowly as they approached the infection site. With that slowed pace, the cell can look for a second signal on the vessel wall that tells the cell to exit the vessel by squeezing between cells in the wall and moving directly to the site of infection.

One reason the system is so effective is that only the neutrophils respond to those selectins, so only neutrophils slow down in the blood.

King was working out the physical dynamics of this
'/>"/>

Contact: Jonathan Sherwood
jonathan.sherwood@rochester.edu
585-273-4726
University of Rochester
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Engineers developing new cements to heal spinal fractures
2. SMRT Architects and Engineers Selected to Design New $115M Digital X-Ray Manufacturing Facility for GE Healthcare
3. Microchip-based device can detect rare tumor cells in bloodstream
4. Microchip Spots Stray Tumor Cells in the Bloodstream
5. CoolTouch Introduces CoolLipo(TM) Laser System, Recently FDA Cleared for Laser-Assisted Lipolysis
6. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
7. Survival differences by race most apparent in advanced stages of breast cancer
8. MRI finds breast cancer before it becomes dangerous
9. Investigators uncover intriguing clues to why persistent acid reflux sometimes turns into cancer
10. Pathway links inflammation, angiogenesis and breast cancer
11. Radiologists encouraged to look beyond cancer for clinically unseen diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... DMG Productions announces the upcoming airing ... broadcast on Wednesday, September 24, 2014 at 7:30 ... episode, Innovations will go behind the scenes to ... each client the opportunity to achieve the highest ... principles of Care, Compassion, and Commitment. , Audiences ...
(Date:9/17/2014)... 2014 Kristen Yarker, MSc, RD recently announced ... children 9 months to 2 years old who are seeking ... picky eaters from developing by encouraging healthy eating habits from ... to 2 years): How to Transition From Baby Food to ... the Nutrition They Need)” is a new online seminar based ...
(Date:9/17/2014)... Wailea, Maui, HI (PRWEB) September 17, 2014 ... has announced the eighth annual Wailea Tennis Fantasy ... 19-23, 2014 at Maui’s prestigious Wailea Tennis Club, with ... ranked Lindsay Davenport returning to Wailea, Maui for her ... world-class instruction and match play with Davenport, recently inducted ...
(Date:9/17/2014)... In a new video released for ... expert on the condition known as PPP, demonstrates a proven ... or PPP, is a condition that affects mostly uncircumcised men ... affected as well. The condition is characterized by small bumps ... is not a sexually transmitted disease and generally has no ...
(Date:9/17/2014)... 17, 2014 Request A Test , ... is offering 10% off drug testing through the ... drug tests, including those ordered by employers for workplace or ... of this discount by using promo code DRUG10 when placing ... positives on workplace drug testing, especially for marijuana or THC. ...
Breaking Medicine News(10 mins):Health News:Innovations to Explore Substance Abuse and Mental Health in Upcoming Episode Airing Wednesday, September 24, 2014 via Discovery Channel. 2Health News:Nutritionist Kristen Yarker Offers Parents a Fresh Approach to Prevent Picky Eaters in New Online Seminar 2Health News:Nutritionist Kristen Yarker Offers Parents a Fresh Approach to Prevent Picky Eaters in New Online Seminar 3Health News:Four Seasons Resort Maui at Wailea Announces 8th Annual Wailea Tennis Fantasy Camp 2Health News:Four Seasons Resort Maui at Wailea Announces 8th Annual Wailea Tennis Fantasy Camp 3Health News:New Video Depicts Best Treatment for PPP 2Health News:New Video Depicts Best Treatment for PPP 3Health News:Request A Test Can Save You 10% on Drug Testing 2Health News:Request A Test Can Save You 10% on Drug Testing 3
... Center have found a new method for identifying suspect ... common acute infections in children. ,Traditionally, researchers ... down the virus or bacteria causing it. But that ... not be present in the blood or other easily ...
... from University of Missouri, Columbia indicates that the masculine tendencies ... been assumed all along that such tendencies were the barriers ... this issue. ,Generally it has been said that ... quality is said to aid in their recovery in traumatic ...
... major Ranbaxy Laboratories Ltd says it has obtained tentative approval ... market a drug for insomnia. ,The US unit ... Drugs, US FDA, has determined the Ranbaxy formulations of Zolpidem ... therapeutic effect as that of Ambien tablets of Sanofi Aventis ...
... Health Services called Frontpoint Systems (http://www.frontpointsystems.co.uk /weblog) has ... Royal College of Obstetricians & Gynaecologists indicating a ... ,The site highlights what is wrong ... in the UK has published a letter from ...
... of Virginia Health System suggests that composition of plaque deposits ... a stroke. ,Published in the March edition of ... deposits in the carotid arteries of 102 patients treated at ... likely to have a stroke, physicians may want to take ...
... the risk of death among children aged 12 to 48 ... conducted by researchers at the Johns Hopkins Bloomberg School of ... in mortality among children 1 to11 months of age. The ... The Lancet. ,Zinc is one of the ...
Cached Medicine News:Health News:‘Fingerprints’ to Track Common Infections in Childr 2Health News:‘Fingerprints’ to Track Common Infections in Childr 3Health News:More Evidence of Racial Discrimination in the NHS 2Health News:Calcium in Arterial Plaque is a Good Indicator for Risk of Stroke 2Health News:Zinc Supplements Enhance Immunity in Children 2
(Date:9/17/2014)... 17, 2014 Cardiac Dimensions ® , Inc. ... the TITAN II clinical trial of its enhanced ... improvements in mitral regurgitation, functional improvement, quality of ... and efficacy data, which was consistent with previous ... at the 26 th annual Transcatheter Cardiovascular ...
(Date:9/17/2014)... , Sept. 17, 2014 Isis Pharmaceuticals, ... it has earned a $4 million milestone payment ... associated with the initiation of a Phase 3 ... resistant (MDR), gram-negative bacterial infections.  The Phase 3 ... evaluate the efficacy and safety of plazomicin compared ...
(Date:9/17/2014)... ALTO, Calif. , Sept. 17, 2014  Neuraltus ... the Company,s Phase 2 clinical program of NP001 for ... Lou Gehrig,s disease) are being highlighted today in ... the ALS Research Group , being held in ... to a  post hoc  analysis, administration of a high ...
Breaking Medicine Technology:Cardiac Dimensions Announces New Long-Term Outcomes Data From TITAN II Clinical Trial Demonstrates Safety, Efficacy Of Enhanced CARILLON Mitral Contour System 2Cardiac Dimensions Announces New Long-Term Outcomes Data From TITAN II Clinical Trial Demonstrates Safety, Efficacy Of Enhanced CARILLON Mitral Contour System 3Isis Pharmaceuticals Earns $4 Million from Achaogen for the Initiation of a Phase 3 Study of Plazomicin 2Isis Pharmaceuticals Earns $4 Million from Achaogen for the Initiation of a Phase 3 Study of Plazomicin 3Neuraltus Pharmaceuticals' ALS Treatment Candidate, NP001, Highlighted at ALS Research Group Summit 2Neuraltus Pharmaceuticals' ALS Treatment Candidate, NP001, Highlighted at ALS Research Group Summit 3
Tennant straight tying forceps with extra delicate smooth jaws, 6 mm tying platform, For 9-0 to 11-0 sutures. Overall length 108 mm....
Catalano curved tying forcep has 6 mm V-grove tying platform. Overall length 100 mm....
McPherson curved tying forceps is long has curved shafts with tying platform 4 mm, serrated handle and polished finish. Overall length 110 mm....
McPherson straight tying forceps have straight shafts, tying platforms 4 mm, serrated handle, polished finish, overall length 85 mm....
Medicine Products: