Navigation Links
Engineers probe mechanics behind rapid-aging disease
Date:9/14/2011

ein tail, when pulled, first breaks nearly in half, forming a large gap near the middle of its folded structure, then begins unfolding sequentially. The MIT scientists deduced that it takes an additional 70 kilocalories per mole (a unit of energy) to straighten the mutant tails, meaning the mutant protein is actually more stable than its healthy counterpart.

At Carnegie Mellon, Dahl and Kalinowski studied the same topic by subjecting lamin A protein tails to heat, which causes proteins to denature or unfold. In their lab, they observed the same pattern of unraveling in healthy and mutated proteins as the MIT engineers did in their atomistic simulation.

Qin then wrote a mathematical equation to convert the temperature differential seen in denaturing the mutant and healthy proteins (4.7 degrees Fahrenheit) to the unit of energy found in the atomistic simulations, finding that the increase in temperature very nearly matched the increase in energy. This agreement, the researchers say, validates the application of the civil engineering methodology to the study of the mutated protein in diseased cells.

The results, however, were counterintuitive to the civil engineers, who are accustomed to flawed materials being weaker not stronger than their unimpaired counterparts.

As a component of the cell's nucleoskeleton, lamin A plays an important role in defining the mechanical properties of a cell's nuclear membrane, which must remain flexible enough to easily withstand deformation. In previous work, Dahl had observed that nuclear membranes built from the mutated proteins become very stiff and brittle, which could explain the altered protein-DNA and protein-protein interactions observed in diseased cells.

"Our surprising finding is that the defective mutant structure is actually more stable and more densely packed than the healthy protein," said Buehler. "This is contrary to our intuition that a 'defective' structure is less stabl
'/>"/>

Contact: Marta Buczek
mbuczek@mit.edu
617-721-5749
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. MIT engineers design new nanoparticle that could lead to vaccines for HIV, malaria, other diseases
2. Tissue engineers create a new way to assemble artificial tissues
3. Engineers turn noise into vision
4. Nanoscale stealth probe slides into cell walls seamlessly, say Stanford engineers
5. Artists, Product Designers, Printing Gurus, Game Developers, Manufacturing Engineers Will Converge at RAPID 2010/3D IMAGING Conference/Expo, May 18-20 in LA
6. X-ray protein probe leads to potential anticancer tactic
7. Imaging probe allows noninvasive detection of dangerous heart-valve infection
8. Study Probes Potential Link Between Welding, Parkinsons Disease
9. Firefly glow: Berkeley Lab scientists develop a hydrogen peroxide probe based on firefly luciferin
10. Provocative new Montreal study probes link between breast cancer and air pollution
11. Fluorescent probe for oral cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2015)... ... September 01, 2015 , ... METTLER TOLEDO ... available. With the Connectivity Kit, EasySampler data is automatically transferred to, and ... experiment, on a touchscreen platform. , EasySampler fully automates the sampling process ...
(Date:9/1/2015)... ... ... Ogawa’s new massage chairs tout innovative functionality that change the way robotic ... With the goal of bringing wellness to the world, Ogawa introduces their new line ... in its name, the Ogawa Refresh aims to “refresh” and rejuvenate the ...
(Date:9/1/2015)... ... September 01, 2015 , ... Éminence Organic ... products, the VitaSkin™ Exfoliating Peels. This revolutionary collection of natural peel solutions complements ... and Clear. , Formulated with alpha hydroxy acids and natural active ingredients, ...
(Date:9/1/2015)... ... September 01, 2015 , ... ... customer communications archiving solution integrated with Alfresco‘s enterprise content management system. PRO ... organizations save millions of dollars in printing costs by digitizing vast amounts ...
(Date:9/1/2015)... ... September 01, 2015 , ... Anthony J. Tantillo, Esq., ... 2015 for his third consecutive year in a row. Through nomination, research and ... people. , Born in Niagara Falls, New York, Tantillo is a Buffalo State College ...
Breaking Medicine News(10 mins):Health News:New Technology Allows Unattended Sampling and Synthesis of Chemical Reactions 2Health News:New Technology Allows Unattended Sampling and Synthesis of Chemical Reactions 3Health News:Ogawa World USA Releases New Massage Chairs to the US 2Health News:Ogawa World USA Releases New Massage Chairs to the US 3Health News:Éminence Organic Skin Care Introduces Results-Oriented Exfoliating Peels for Every Skin Type 2Health News:Éminence Organic Skin Care Introduces Results-Oriented Exfoliating Peels for Every Skin Type 3Health News:Introducing Next-Generation Archiving Solution PRO Archiver for Alfresco® 2Health News:Introducing Next-Generation Archiving Solution PRO Archiver for Alfresco® 3
... LCA-Vision Inc. (Nasdaq:,LCAV), a leading provider of laser ... financial and operational results for,the three months and ... Quarter 2008 Financial & Operational Results (all comparisons ... Revenue was $37.4 million compared with $74.6 million; ...
... November, Philips Norelco,will partner with the charitable organization ... that affects one in six American men.,Movember, the ... an annual,global ",Mo,-vement" to raise funds for prostate ... the U.S. is the Prostate Cancer Foundation,(PCF), which ...
... MINNEAPOLIS, Oct. 28 It,s estimated that almost 2.5,million ... by 2020, of those,44% will be over the age ... effects of diabetes are vividly present. While Medicare can ... is,particularly critical to managing complicated medical conditions., It,s ...
... team, Dr. Bob Basu, MD, MPH, FACS and Dr. Sugene Kim, MD ... DIEP free flap breast reconstruction procedure in The Woodlands at the Memorial ... ... 2008 -- Dr. Bob Basu and Dr. Sugene Kim, were recently featured ...
... Staffing Company with over 100 million Dollars of Revenue , ... Alpharetta, ... been named the 5th largest healthcare staffing company ranked by total revenue ... SIA, firms are ranked on the list by temporary staffing revenue generated ...
... seizures with the sedative propofol may be at high ... at CHEST 2008, the 74th annual international scientific assembly ... that the use of propofol as an antiepileptic agent ... that do not respond to initial treatment, was associated ...
Cached Medicine News:Health News:LCA-Vision Reports Third Quarter 2008 Financial Results 2Health News:LCA-Vision Reports Third Quarter 2008 Financial Results 3Health News:LCA-Vision Reports Third Quarter 2008 Financial Results 4Health News:LCA-Vision Reports Third Quarter 2008 Financial Results 5Health News:LCA-Vision Reports Third Quarter 2008 Financial Results 6Health News:LCA-Vision Reports Third Quarter 2008 Financial Results 7Health News:LCA-Vision Reports Third Quarter 2008 Financial Results 8Health News:LCA-Vision Reports Third Quarter 2008 Financial Results 9Health News:LCA-Vision Reports Third Quarter 2008 Financial Results 10Health News:LCA-Vision Reports Third Quarter 2008 Financial Results 11Health News:LCA-Vision Reports Third Quarter 2008 Financial Results 12Health News:LCA-Vision Reports Third Quarter 2008 Financial Results 13Health News:Philips Norelco Encourages Americans to Change the Face of Men's Health: Grow a Moustache This November and Raise Awareness for Prostate Cancer Research 2Health News:Philips Norelco Encourages Americans to Change the Face of Men's Health: Grow a Moustache This November and Raise Awareness for Prostate Cancer Research 3Health News:Philips Norelco Encourages Americans to Change the Face of Men's Health: Grow a Moustache This November and Raise Awareness for Prostate Cancer Research 4Health News:Advanced Health Care Options for People With Diabetes 2Health News:Plastic Surgery Team Pioneered the First DIEP Free Flap Breast Reconstruction in The Woodlands, Texas 2Health News:Plastic Surgery Team Pioneered the First DIEP Free Flap Breast Reconstruction in The Woodlands, Texas 3Health News:Plastic Surgery Team Pioneered the First DIEP Free Flap Breast Reconstruction in The Woodlands, Texas 4Health News:Jackson Healthcare Named 5th Largest Healthcare Staffing Company 2Health News:Jackson Healthcare Named 5th Largest Healthcare Staffing Company 3Health News:Anti-seizure drug could be fatal 2
(Date:8/31/2015)... Ohio , Aug. 31, 2015 ... applications, has acquired MACTek Corporation, a leading provider ... of Pepperl+Fuchs, strategy to further extend its integrated ... WirelessHART market.    "We are pleased ... our existing portfolio," said Jim Bolin , ...
(Date:8/31/2015)... 2015 With increasing clinical applications, the ... rise in active partnerships. The primary reason for ... quantitate CD4 cell markers in human immunodeficiency virus ... New analysis from Frost ... Market ( http://www.frost.com/nf0e ), finds the market earned ...
(Date:8/31/2015)... , Aug. 31, 2015  Regulatory affairs professionals ... where regulations are often strict and legislation is ... a demand for professionals who have a deep ... across a product lifecycle and demonstrate its use ... University of California, Irvine Extension , in partnership ...
Breaking Medicine Technology:Clinical Applications of Flow Cytometry Instrumentation and Reagents are Transforming this Market with a High-Growth Path 2Clinical Applications of Flow Cytometry Instrumentation and Reagents are Transforming this Market with a High-Growth Path 3Clinical Applications of Flow Cytometry Instrumentation and Reagents are Transforming this Market with a High-Growth Path 4UC Irvine Extension Launches New Regulatory Affairs and Compliance Certificate Program 2UC Irvine Extension Launches New Regulatory Affairs and Compliance Certificate Program 3
... , , ...  (AIM: CRW.L), the market leader in automated revenue integrity ... new product and its first customer. , Supplies ... manage and optimize reimbursement for chargeable supplies. It does this ...
... , , JERUSALEM , ... privately held biopharma company, announced today that it has granted Novartis ... the Company,s Transient Permeability Enhancer (TPE) technology for use with certain ... Novartis. In a separate but related agreement, the MPM Bio ...
Cached Medicine Technology:Craneware's New Product Reduces Supply Chain Revenue Leakage 2Craneware's New Product Reduces Supply Chain Revenue Leakage 3Craneware's New Product Reduces Supply Chain Revenue Leakage 4Chiasma Grants Option to License Transient Permeability Enhancer (TPE) Technology for Small Molecule Products 2Chiasma Grants Option to License Transient Permeability Enhancer (TPE) Technology for Small Molecule Products 3
... next generation system for ... the power of automation ... laboratory. As many as ... loaded and analyzed in ...
The NIAGARA Thermal Retention System (TRS) maintains the temperature of prewarmed irrigation fluid continuously as it is delivered through the Corson®, Surgiflex® WAVE™, or Surgiflex D...
Simple, Effective Laparoscopic Irrigation Pumps from the Market Leader...
Stryker Endoscopy has combined a standardized pressurizing system with an advanced hand piece design that is lightweight and compact in order to streamline laparoscopic procedures....
Medicine Products: