Navigation Links
Engineers improve blood testing technology with smartphone app, hand-held biosensor

KINGSTON, R.I. September 6, 2012 A team of engineers and students at the University of Rhode Island has developed an advanced blood-testing technology that incorporates a smartphone application, a hand-held biosensor and a credit card-sized cartridge to provide rapid, accurate biological analysis and wireless communication of test results.

This new lab-on-a-chip technology improves upon a previous system announced by the URI team in 2011 that generated enthusiasm among many sectors of the health care industry. Several patents are pending on the invention.

"We went from a shoebox-size device last year to a hand-held device with several additional capabilities," said Mohammad Faghri, URI professor of mechanical engineering and the lead researcher on the project. "The smartphone app turns the system on, monitors the assay, and sends the results securely back to your phone or to your doctor, all in about 20 minutes."

Faghri said the advancements make the new system faster, more accurate, easier to use, and much less expensive than previous versions. For example, the fluorescence sensor in the hand-held unit costs less than $10 compared to the $3,200 sensor in the shoe-box system.

"It's accuracy, compactness and low cost are a result of an innovative contact imaging system that serves as the fluorescence detector and the central piece of the fluid feedback control system," Faghri said.

To operate the system, users place a drop of blood from a finger prick on a disposable plastic polymer cartridge and insert it into the hand-held biosensor. The blood travels through the cartridge in tiny channels 500 microns wide to a detection site where it reacts with preloaded reagents enabling the sensor to detect certain biomarkers of disease.

"Today when you go to the lab to have a blood test, they take vials of liquid from you and you have to wait sometimes days to get the results," Faghri said. "With our system, you can have your blood tested when you walk into the doctor's office and the results will be ready before you leave. Or you can do it at home and have the results sent to your doctor in real time."

Faghri even envisions having astronauts at the International Space Station test their blood and sending the results wirelessly back to Earth.

The first cartridges the researchers developed focus on the detection of C-reactive proteins in the blood, a preferred method for helping doctors assess the risk of cardiovascular and peripheral vascular diseases. Additional cartridges can be engineered to detect biomarkers of other diseases, including the beta amyloid protein that can be used as a predictor of Alzheimer's disease. The device can also be developed to detect virulent pathogens, like HIV, hepatitis B and H1N1 (swine) flu.

One of the most important advancements of the new device is that it can conduct the test on whole blood rather than blood plasma. The cartridge filters out the cellular components of blood, as well as some of the abundant non-target proteins that often interfere with the detection of the targeted protein.

The third generation of the device, currently in development, will put the entire lab on paper, eliminating the need for active pumping of blood and reagents through the cartridge.

Contact: Todd McLeish
University of Rhode Island

Related medicine news :

1. Rice University student engineers automate limb lengthening for kids
2. UCLA bioengineers discover single cancer cell can produce up to 5 daughter cells
3. Worlds fastest camera, created by UCLA engineers, used to detect rogue cancer cells
4. UT Dallas engineers identify material that reduces pollution from diesel engines
5. Clinical insight improves treatment with new lung cancer drug
6. Improved Stem Cell Line May Avoid Tumor Risk: Study
7. Normalizing tumor blood vessels improves delivery of only the smallest nanomedicines
8. Exercise improves quality of life during breast cancer treatment
9. IU, Regenstrief automated system aims to improve child health
10. Swallowing exercises linked with short-term improvement among patients with head and neck cancer
11. MU receives national award for using mind-body approach to improve health
Post Your Comments:
(Date:6/25/2016)... ... , ... "With 30 hand-drawn hand gesture animations, FCPX users can easily customize ... Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures into ... Simply select a ProHand generator and drag it above media or text in the ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits of ... of the latter, setting the bar too high can result in disappointment, perhaps even ... progress toward their goal. , Research from reveals that behind ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary ... Dallas that it will receive two significant new grants to support its work ... marked its 25th anniversary by recognizing patients, medical professionals and scientists for their ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are sharpening their ... Award, an essay contest in which patients and their families pay tribute to a ... the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. ...
(Date:6/24/2016)... ... ... National recruitment firm Slone Partners is pleased to announce the ... as Vice President of North American Capital Sales at HTG Molecular . ... team in the commercialization of the HTG EdgeSeq system and associated reagents in North ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016 Bracket , a leading ... next generation clinical outcomes platform, Bracket eCOA (SM) 6.0, ... June 26 – 30, 2016 in Philadelphia ... Clinical Outcome Assessment product of its kind to fully integrate ... Bracket eCOA 6.0 is a flexible platform for electronic ...
(Date:6/23/2016)... and INDIANAPOLIS , June 23, 2016 ... Lilly Diabetes Tomorrow,s Leaders Scholarship is any indication, the ... announced today online at by the ... diabetes stand in the way of academic and community ... Foundation,s scholarship program since 2012, and continues to advocate ...
(Date:6/23/2016)... -- Revolutionary technology includes multi-speaker listening to ... leaders in advanced audiology and hearing aid technology, has ... the world,s first internet connected hearing aid that opens ...      (Photo: ) , ... firsts,: , TwinLink™ - the first dual ...
Breaking Medicine Technology: