Navigation Links
Engineering center to probe forces that cause cancer to spread
Date:10/26/2009

more aggressively invade the surrounding normal tissues where oxygen is more plentiful. Hypoxia-inducible factor 1 controls the responses of cancer cells to low oxygen, and we have recently identified drugs that block the action of HIF-1 and inhibit tumor growth in experimental cancer models."

The center's second key research project teams Wirtz with Greg D. Longmore, a cancer cell biologist at Washington University in St. Louis. The two will study the physical basis for cancer cell adhesion and de-adhesion and how it increases the likelihood that cancer cells will break free, move into the bloodstream and migrate to other tissues. "Cancer cells are able to modulate proteins on the surface almost like a protein 'brake' that allows them to adhere or de-adhere in response to mechanical forces," Wirtz said.

The center's third primary research project will be led by Konstantinos Konstantopoulos, professor and chair of the Whiting School's Department of Chemical and Biomolecular Engineering, and Martin L. Pomper, who holds appointments in the School of Medicine's Department of Radiology and the Kimmel Cancer Center. These two researchers will investigate the effects of fluid mechanical forces at different oxygen tension microenvironments on tumor cell signaling, adhesion and migration.

"Fluid flow in and around tumor tissue modulates the mechanical microenvironment, including the forces acting on the cell surface and the tethering force on cell-substrate connections," Konstantopoulos said. "Cells in the interior of a tumor mass experience a lower oxygen tension microenvironment and lower fluid velocities than those at the edges in proximity with a functional blood vessel and are prompted to produce different biochemical signals. These differential responses affect tumor cell fatethat is, whether a cell will live or die, and whether it will be able to detach and migrate to secondary sites in the body."

All three projects will combi
'/>"/>

Contact: Mary Spiro
mspiro@jhu.edu
410-516-4802
Johns Hopkins University
Source:Eurekalert

Page: 1 2 3 4 5 6

Related medicine news :

1. MSU engineering team designs innovative medical device
2. Specialty Blades, Inc. Expands Management Team With New VP Engineering
3. McGraw-Hill Professional Enhances Library Access to Medical and Engineering Resources
4. Riverside Partners Teams with Management to Acquire GEMCITY Engineering & Manufacturing
5. Bayer Foundation Grant Creates Graduate Engineering Fellowship at University of Houston
6. American Oriental Bioengineering Announces Participation in November Healthcare Conferences
7. Springer to publish Sports Engineering
8. American Oriental Bioengineering to Present at the ICR XChange Asia Institutional Investor Conference
9. Antibody Engineering Company f-star Appoints Three Pioneers in Antibody Engineering and Development to its Newly Established Scientific Advisory Board
10. CDI-Life Sciences Selected by CJ CheilJedang Corp. to Provide Engineering Design for Major Pharmaceutical Complex in Korea
11. MedImmune Expands Scientific and Engineering Leadership
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2015)... Texas (PRWEB) , ... August 28, 2015 , ... Yisrayl ... a new publication and pleads for swift actions to be taken in order ... unnatural disasters. , Yisrayl says scientists have yet to understand fully the real ...
(Date:8/28/2015)... BOSTON, MA (PRWEB) , ... August 28, 2015 ... ... WorldCare International, Inc. ’s online medical consultations result in high percentages of change ... performed by the Center for Healthcare Informatics at Tennessee Tech University and analyzed ...
(Date:8/28/2015)... ... August 28, 2015 , ... On October 3, 2015, BethAnn Telford of TeamBT ... the Grand Canyon with a shared mission: to beat brain cancer. In one grueling ... the canyon, then up to the South Rim over 21.1 miles and more than 10,000 ...
(Date:8/27/2015)... ... ... This new webinar educates providers about how can they create a scalable and ... authorizations are in check, and they are current with their payments. Learn ... Software, growing a practice depends on patient experience and clinician’s relationship with the patient. ...
(Date:8/27/2015)... ... August 27, 2015 , ... In the addiction treatment industry, some ... months later, relapsing and returning again, all at great cost to them and their ... living homes or soon after leaving facilities who claim to have given addicts tools ...
Breaking Medicine News(10 mins):Health News:Wake Up and Smell the Sick Atmosphere Says Yisrayl Hawkins in New Article This Week 2Health News:WorldCare International, Inc. Celebrates Findings of Independent ROI Study 2Health News:Women Athletes Cross the Grand Canyon to Raise Funds for Brain Cancer Research – October 3rd 2Health News:A New Webinar Teaches Chiropractors How to Use Compliance Alerts to Manage Patient Relationships 2Health News:National Screenings of Documentary Indicate Burgeoning Questions about the Effectiveness of Addiction Treatment Facilities 2Health News:National Screenings of Documentary Indicate Burgeoning Questions about the Effectiveness of Addiction Treatment Facilities 3
... the billions of pounds being spent on hospitals for the NHS ... of care.// ,The report has claimed that the NHS ... 30 years to pay off, when the present plans for the ... people live. ,According to this report the Department of ...
... have suggested that some links exist between Alzheimer's and Type ... two are actually// different forms of the same disease. ... causes to the pancreas is similar to the effect of ... on Saturday during the International Conference on Alzheimer's Disease and ...
... the lowest number of reported HIV/Aids cases in the world ... prove it.// ,This was the conclusion of the ... Ministry of Health. Neighboring countries have also reported a similar ... behavioral norms have contributed to keeping infection at very low ...
... sleep-deprived youth working continuously on night shifts in BPO ... night, skipping breakfast, eating lunch in the evening and ... Lim Li Ling, Deputy Director, sleep disorders unit, Singapore ... would be affected due to lack of proper sleep, ...
... Indian Ocean such as Mauritius have been struck by a ... far, according to doctors. // ,The chikungunya virus ... and rashes and is potentially lethal. It has ravaged the ... Researchers from the University of Lausanne, Switzerland have reported the ...
... U.S. are suffering from long-term spinal cord injuries, with more ... ,One study appearing in the July 12th issue of the ... towards providing evidence that a combination of treatments could lead ... The result would be a return of functional activity. ...
Cached Medicine News:Health News:Diabetes and Alzheimer's disease May be Two Sides of the Same Coin 2
(Date:8/27/2015)... 27, 2015 According to a ... Type (Integrated, Standalone), by Deployment Mode (Web based, On-Premise, ... Healthcare Service Providers), by Component - Global Trends & ... is estimated at $501.1 Million 2014, and is projected ... of 7.6% from 2014 to 2019. ...
(Date:8/27/2015)... 2015  Mytrus, a technology and services company revolutionizing clinical trials, ... consent has received approval for use by ... the first time e-Consent technology will be used in ... Mytrus was also the first electronic informed ... by the U.S. Food and Drug Administration in 2011. ...
(Date:8/27/2015)... Colo. , Aug. 27, 2015  Lightwave ... on the development of Next Generation Photonic ... for applications in high speed fiber-optic data communications ... Michael Lebby has been appointed to the ... reputation in the field of optoelectronics is widely ...
Breaking Medicine Technology:Radiology Information Systems Market Worth $722.7 Million by 2019 2Radiology Information Systems Market Worth $722.7 Million by 2019 3Radiology Information Systems Market Worth $722.7 Million by 2019 4Britain's National Health Service Approves The Use Of Mytrus Technology For Electronic Informed Consent In Clinical Trials 2Britain's National Health Service Approves The Use Of Mytrus Technology For Electronic Informed Consent In Clinical Trials 3Britain's National Health Service Approves The Use Of Mytrus Technology For Electronic Informed Consent In Clinical Trials 4Britain's National Health Service Approves The Use Of Mytrus Technology For Electronic Informed Consent In Clinical Trials 5Britain's National Health Service Approves The Use Of Mytrus Technology For Electronic Informed Consent In Clinical Trials 6Britain's National Health Service Approves The Use Of Mytrus Technology For Electronic Informed Consent In Clinical Trials 7Lightwave Logic Announces the Appointment of Optoelectronics Industry Leader, Michael Lebby, Ph.D. to its Board of Directors 2Lightwave Logic Announces the Appointment of Optoelectronics Industry Leader, Michael Lebby, Ph.D. to its Board of Directors 3
... 2011 With the support of Key Opinion Leaders ... the time and attention of KOLs is intensifying. But ... landscape for creating and maintaining KOL and physician relationships. ... KOL landscape, Best Practices, LLC has published an updated ...
... Endo Pharmaceuticals (Nasdaq: ENDP ) announced today ... of President, HealthTronics Inc., effective Aug. 29, 2011. HealthTronics, ... urological products and services based in Austin, Texas. ... HealthTronics Group President James Whittenburg, who is staying through ...
Cached Medicine Technology:Pharma Medical Science Liaison Outreach Shifting Away from Traditional Company Sales Regions 2Endo Pharmaceuticals Announces Leadership Change at HealthTronics Subsidiary: Appoints Kelly Huang, Ph.D. New President 2Endo Pharmaceuticals Announces Leadership Change at HealthTronics Subsidiary: Appoints Kelly Huang, Ph.D. New President 3
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: