Navigation Links
Engineering center to probe forces that cause cancer to spread
Date:10/26/2009

more aggressively invade the surrounding normal tissues where oxygen is more plentiful. Hypoxia-inducible factor 1 controls the responses of cancer cells to low oxygen, and we have recently identified drugs that block the action of HIF-1 and inhibit tumor growth in experimental cancer models."

The center's second key research project teams Wirtz with Greg D. Longmore, a cancer cell biologist at Washington University in St. Louis. The two will study the physical basis for cancer cell adhesion and de-adhesion and how it increases the likelihood that cancer cells will break free, move into the bloodstream and migrate to other tissues. "Cancer cells are able to modulate proteins on the surface almost like a protein 'brake' that allows them to adhere or de-adhere in response to mechanical forces," Wirtz said.

The center's third primary research project will be led by Konstantinos Konstantopoulos, professor and chair of the Whiting School's Department of Chemical and Biomolecular Engineering, and Martin L. Pomper, who holds appointments in the School of Medicine's Department of Radiology and the Kimmel Cancer Center. These two researchers will investigate the effects of fluid mechanical forces at different oxygen tension microenvironments on tumor cell signaling, adhesion and migration.

"Fluid flow in and around tumor tissue modulates the mechanical microenvironment, including the forces acting on the cell surface and the tethering force on cell-substrate connections," Konstantopoulos said. "Cells in the interior of a tumor mass experience a lower oxygen tension microenvironment and lower fluid velocities than those at the edges in proximity with a functional blood vessel and are prompted to produce different biochemical signals. These differential responses affect tumor cell fatethat is, whether a cell will live or die, and whether it will be able to detach and migrate to secondary sites in the body."

All three projects will combi
'/>"/>

Contact: Mary Spiro
mspiro@jhu.edu
410-516-4802
Johns Hopkins University
Source:Eurekalert

Page: 1 2 3 4 5 6

Related medicine news :

1. MSU engineering team designs innovative medical device
2. Specialty Blades, Inc. Expands Management Team With New VP Engineering
3. McGraw-Hill Professional Enhances Library Access to Medical and Engineering Resources
4. Riverside Partners Teams with Management to Acquire GEMCITY Engineering & Manufacturing
5. Bayer Foundation Grant Creates Graduate Engineering Fellowship at University of Houston
6. American Oriental Bioengineering Announces Participation in November Healthcare Conferences
7. Springer to publish Sports Engineering
8. American Oriental Bioengineering to Present at the ICR XChange Asia Institutional Investor Conference
9. Antibody Engineering Company f-star Appoints Three Pioneers in Antibody Engineering and Development to its Newly Established Scientific Advisory Board
10. CDI-Life Sciences Selected by CJ CheilJedang Corp. to Provide Engineering Design for Major Pharmaceutical Complex in Korea
11. MedImmune Expands Scientific and Engineering Leadership
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 2015 Blue Cross and Blue Shield of ... what it means to “Live Fearless.” , The ... share their stories about how they or someone they know ... by living in the moment. By telling these types of ...
(Date:1/22/2015)... Juvent Sports ( http://www.juventsports.com ) and ... Merchandise Show to bestow a Juvent Sports Achievement award ... Arlene McKitrick. The award commemorated and congratulated McKitrick for ... She won her first amateur tournament in 1979 and ...
(Date:1/22/2015)... January 22, 2015 Autocarinsurancebest.com has released a ... a commercial auto insurance policy . , Auto insurance ... vehicles. It is no longer necessary to call an agent ... now available online on a single website: http://autocarinsurancebest.com/ . ...
(Date:1/22/2015)... Joan Lunden, award-winning American journalist, beloved television host, ... 32nd Annual Miami Breast Cancer Conference planned and ... , shares that “a fast-growing, virulent” cancer in her ... not followed up her clean mammogram with an ultrasound. ...
(Date:1/22/2015)... 23, 2015 Recently, Weddingshe.com has added many ... has announced its highest annual revenues in the past three ... popular glamorous wedding dresses. , According to the sales manager ... dress promotions for them in 2015. This point can be ...
Breaking Medicine News(10 mins):Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3Health News:Commercial Auto Insurance Provides Several Important Features! 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 4Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 5Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 6Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2
... and support for those suffering from anorexia. ... Lothian//, said that all measures are being taken to ... Executive said that help would be provided for people ... in the Ombudsman's report. Mr Duncanson expressed his condolences ...
... the Indian Council of Medical Research (ICMR) today signed an ... medicinal plants or multi-herb formulations that have never been compiled. ... five years was signed by ICMR Director General N K ... ,As per the MoU, the ICMR will work towards validating ...
... With dengue, viral fever and malarial attacks reported in ... to appoint 30 doctors on contract and engage para-medical ... Mayor-in-Council (Health) Subodh De said that only dengue cases ... fanned out for surveillance in the affected areas., ...
... more than 2.85 lakh population in parts of Karnataka was coming ... ,As against 1.20 lakh cases reported till April this year, it ... so far, Minister for Health R Ashok said while making a ... government has failed to take urgent steps to contain the spread ...
... conducted on 28,000 postmenopausal women has shown that those who ... were benefited by a 3 percent reduction in risk of ... completely. ,Though the scientists were not able to place ... the diabetes risk, yet they strongly feel that the presence ...
... in the United States and the Far East who use ... blindness. ,Investigators have warned contact lens users about ... lead to the withdrawal of one type of a lens ... affected. ,Researchers have also explained that many people ...
Cached Medicine News:Health News:Investigations Reveal That Infections Due To Contact lens Could Cause Blindness 2
(Date:1/23/2015)... 23, 2015 Research and Markets ( http://www.researchandmarkets.com/research/vzhr6h/video ) ... Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 ... communication has been the topic of fascination since the era ... and the Soviet Russia. Earlier even a small ...
(Date:1/23/2015)...  A new analysis of Centers for Medicare and Medicaid ... that 81 percent of seniors chose lower-cost preferred pharmacy ... certain pharmacies. The findings were released by Drug ... the foundation of Medicare Part D," said Pharmaceutical Care ...
(Date:1/23/2015)... and DUBLIN , Jan. 23, 2015  Immune ... KRS Global Biotechnology, Inc. for the compounding, packaging and distributing ... shipment in the United States . ... Facility capable of compounding naltrexone tablets in various strengths for ...
Breaking Medicine Technology:Video Telemedicine Market- Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Video Telemedicine Market- Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3New Analysis: 81 Percent of Medicare Part D Seniors Choose "Preferred Pharmacy" Plans in 2015 2Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 2Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 3Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 4
... BEIJING , April 22 /PRNewswire-Asia-FirstCall/ -- Lotus Pharmaceuticals,Inc. ... medicine and drugs in the People,s,Republic of China (the "PRC"), today reported ... April 24-26, 2010, Venue: ... Primary Booth: Liang Fang, Beijing Delegate Area, , ...
... April 22 CardioGenics Inc. (OTC Bulletin Board: CGNH), a developer ... market, will be spotlighted in three publications during the month of April: ... The Wall Street Transcript . , ... In the April 2010 print and online editions ...
Cached Medicine Technology:Lotus Pharmaceuticals to Exhibit at the 63rd PHARMCHINA 2CardioGenics to be Spotlighted in Three Publications During Month of April 2CardioGenics to be Spotlighted in Three Publications During Month of April 3CardioGenics to be Spotlighted in Three Publications During Month of April 4
Single Use Reloadable Stapler with Titanium Staples., ,The Auto Suture™ PREMIUM MULTIFIRE TA™ stapler has applications in abdominal, gynecological, pediatric and thoracic surgical proced...
... Auto Suture™ POLY GIA™ 75-.060 single ... staggered rows of LACTOMER™ absorbable copolymer ... between the two, double rows., ... single use surgical stapler has application ...
... Use Loading Cartridges With Titanium Staples for ... With Titanium Staples)., ,The PI™ disposable ... resection or transection of normal, healthy internal ... row (or triple staggered row, when using ...
... Single Use Loading Units With Titanium ... Use Reloadable Staplers With Titanium Staples)., ... 80 single use surgical staplers with MULTIFIRE ... units and the Auto Suture™ MULTIFIRE SGIA™ ...
Medicine Products: