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Engineering center to probe forces that cause cancer to spread
Date:10/26/2009

s that complement existing genetic or molecular treatments."

In a congratulatory letter to Wirtz concerning the new center, Johns Hopkins President Ronald J. Daniels wrote, "This is a terrific achievement that highlights the value of interdisciplinary research and collaboration across the university and the increasing importance this approach will have in the coming years. I am especially proud to see Johns Hopkins lead the way in this manner. Not only will you be embarking into a new realm of scientific collaboration, you will be, at the same time, establishing Johns Hopkins as a leading center of excellence in this field. The ongoing fight against cancer demands new ideas, perspectives and approaches, and that is precisely what you are creating in [this] center."

Semenza, the associate director, is affiliated with the School of Medicine's departments of Pediatrics, Medicine, Oncology and Radiation Oncology, and the McKusick-Nathans Institute of Genetic Medicine. He is the C. Michael Armstrong Professor in Medicine and founding director of the Vascular Program at the school's Institute for Cell Engineering. He also has ties to the School of Medicine's Department of Biological Chemistry and to the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins.

Semenza and Sharon Gerecht, an assistant professor of chemical and biomolecular engineering, will lead one of the center's three key research projects related to how cancer spreads. They will focus on analyzing the makeup and physical properties of the extracellular matrix, the three-dimensional scaffold in which cells live.

"Normal cells live in a flexible scaffold, but cancer cells create a rigid scaffold that they climb through to invade normal tissue," Semenza said. "We will study how this change occurs and how it is affected by the amount of oxygen to which cancer cells are exposed. Our studies have shown that cancer cells are deprived of oxygen, which incites them to
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Contact: Mary Spiro
mspiro@jhu.edu
410-516-4802
Johns Hopkins University
Source:Eurekalert

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