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Engineering center to probe forces that cause cancer to spread
Date:10/26/2009

tumor growth and metastasis."

Denis Wirtz, a professor of chemical and biomolecular engineering in the Whiting School of Engineering, will direct the center, and Gregg L. Semenza, a leading researcher at the School of Medicine, will serve as associate director.

"Metastasis is a highly coordinated, multistep process," Wirtz said. "Cancer cells break free from a primary tumor, penetrate into the bloodstream, evade host defenses, stick to the interior walls of blood vessels and travel to other organs, where they set up new cancer cell colonies. During this cascade of events, tumor cells push on and are pushed by mechanical forces within their microenvironment. Cells translate those mechanical forces into biochemical signals that affect cell growth and function. If we can gain a better understanding of this process, we may find new and better ways to treat cancer."

Wirtz, who is principal investigator, also serves as associate director of the university's Institute for NanoBioTechnology, a cross-divisional institute launched in May 2006 with 185 Johns Hopkins faculty members who are using nanoscience to answer questions in medicine, the basic sciences and public health.

The new cancer center will similarly draw on Johns Hopkins researchers with diverse expertise to study the role of physical forces involved in the development and spread of cancer.

"Mechanical forces inside the body, such as shear exerted by blood flowing through blood vessels, typically destroy the millions of cancer cells that are constantly shed from tumors," Wirtz said. "But the 'fittest' of cancer cells survive these Darwinian-like selective pressures and may become the culprits that spread cancer. Little is known about the effect of mechanical forces on the regulation of cancer cell growth. That is what the Engineering in Oncology Center and the National Cancer Institute want to find out. The results should point us to therapies and diagnostic tool
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Contact: Mary Spiro
mspiro@jhu.edu
410-516-4802
Johns Hopkins University
Source:Eurekalert

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