Navigation Links
Engineered virus targets and kills apparent cancer stem cells in neuroblastoma
Date:1/20/2009

, the research team took human neuroblastoma cells and grew them in laboratory cultures. The cultures contained cells exhibiting biological properties of neural stem cells which are specific to the nervous system and grow to form a variety of nerve tissue. The cultures generated cell colonies that acted like stem cells in the way they divided, grew and were capable of diverse, or multi-lineage, differentiation. Analysis showed the cells also carried known biological markers for nerve stem cells, such as the proteins CD133 and nestin.

The cells advanced into tumor-like cell spheres and were tumorigenic, meaning they had the potential to form tumors. Cells derived from these tumorspheres were relatively resistant to the chemotherapy agent doxorubicin, similar to that seen with some treatment-resistant neuroblastomas. Researchers also noted cells from the tumorspheres carried a gene (MYCN) that is found at amplified levels in aggressive forms of neuroblastoma.

Because neural stem cells and neuroblastoma cells both carry the protein nestin, Dr. Cripe and his colleagues tested the effect of an oncolytic herpes simplex virus called rQNestin34.5 on cells. Developed by cancer researchers Ohio State University, rQNestin34.5 carries a molecular promoter for nestin, which causes it to seek out the protein and cancerous, or precancerous, cells where nestin resides. The virus is genetically programmed to grow inside and be toxic to cancer cells, while leaving healthy tissues alone.

The tumorigenic cells were infected with rQNestin34.5 and then injected into mice to see if neuroblastoma tumors would form. Tumors did not form in any of the mice over a 60-day observation period, leading the researchers to report that rQNestin34.5 "abolished tumor growth" by attacking apparent tumor-initiating cells.

In comparison experiments for control, researchers also infected tumorigenic cells with another oncolytic herpes virus called rQLuc, which does not
'/>"/>

Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. FDA Issues Final Regulations for Genetically Engineered Animals
2. E. coli engineered to produce important class of antibiotic, anti-cancer drugs
3. Top Athletes Join Forces for a New Mission: Athlete-Engineered Skincare to Support Performance and Benefit Charity
4. FDA Proposes Regulations for Genetically Engineered Animals
5. Tumor suppressor genes speed up and slow down aging in engineered mouse
6. OrbusNeich Receives Approval to Market Genous(TM) Bio-engineered R stent(TM) in Taiwan
7. Symposium at Angioplasty Summit TCT Asia Pacific 2008 Features OrbusNeichs Genous(TM) Bio-engineered R stent(TM)
8. Reconstructing mandibular defects with bioengineered tooth and bone
9. Nanomedicine system engineered to enhance therapeutic effects of injectable drugs
10. 5,000 Patients Treated With OrbusNeichs Genous(TM) Bio-engineered R Stent(TM) Now Enrolled in Real-Life Use Global Registry
11. T vs. B: Re-engineered human T cells effectively target and kill cancerous B cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... 2014 The National Association of ... million Science Education Partnership Award (SEPA) grant from ... collaborative project with the Hispanic Communications Network (HCN) ... This collaborative NIH R25 program has been established ... diversity among health professionals by recruiting and interviewing ...
(Date:8/20/2014)... August 20, 2014 New Jersey’s Medical ... of an estimated tens of thousands of patients in ... Bill A3525—a bill that would expand the list of ... own cannabis—earlier this summer by State Assemblywoman Linda Stender, ... quality marijuana is growing. , To help fill the ...
(Date:8/20/2014)... Verndale is pleased to announce their ... exclusive list ranking the fastest-growing private companies in America. ... their yearly percentage revenue growth over a three-year period. ... Inc. 5000 list where it ranked number 2,855. , ... clients a wide range of digital marketing services including ...
(Date:8/20/2014)... 2014 B. E. Smith, the only ... has been retained to lead a national chief ... System in Hermiston, Ore. The top executive search ... has recently placed more than 900 healthcare executives into ... a progressive, not-for-profit healthcare organization serving a population of ...
(Date:8/20/2014)... 2014 Biosimilars, which are similar ... through an abbreviated process, could reap billions in ... Information Services, Inc.’s (AIS) Specialty Pharmacy News offers ... the Food and Drug Administration’s (FDA) recent acceptance ... approval. , Drugmaker Sandoz said July 24 that ...
Breaking Medicine News(10 mins):Health News:National Association of Hispanic Nurses (NAHN) Receives Five-Year Federal Grant from the National Institutes of Health (NIH) 2Health News:National Association of Hispanic Nurses (NAHN) Receives Five-Year Federal Grant from the National Institutes of Health (NIH) 3Health News:Oaksterdam University to Host Four-Day Educational Marijuana Horticultural Seminar Aug 23-26; Training Fills Information Gap for Medical Marijuana Caregivers and Patients 2Health News:Oaksterdam University to Host Four-Day Educational Marijuana Horticultural Seminar Aug 23-26; Training Fills Information Gap for Medical Marijuana Caregivers and Patients 3Health News:For the 8th Time, Verndale Has Been Honored on the Inc. 5000 List 2Health News:Good Shepherd Health Care System Retains B. E. Smith to Recruit New COO 2Health News:Good Shepherd Health Care System Retains B. E. Smith to Recruit New COO 3Health News:AIS Newsletter Tracks Latest Developments in Biosimilars Market as FDA Accepts First Application 2Health News:AIS Newsletter Tracks Latest Developments in Biosimilars Market as FDA Accepts First Application 3
... TUESDAY, Jan. 4 (HealthDay News) -- President Barack Obama ... gives the U.S. Food and Drug Administration unprecedented powers ... The Food Safety Modernization Act, first passed by the ... represents the first significant strengthening of the nation,s food ...
... (HealthDay News) -- Levels of schooling may affect treatment and ... called acute ST-segment elevation myocardial infarction (STEMI), a new study ... attack, STEMI occurs when the coronary artery is totally blocked, ... In the new study, Dr. Rajendra H. Mehta, from ...
... N.C. A tiny light source and sensors at the ... to identify pre-cancerous cells in the lining of the esophagus. ... tested on patients during a clinical trial at the University ... promise of being a less invasive method for testing patients ...
... for the 2013 America,s Cup has been announced, a study ... smooth sailing. The study was published recently in the journal ... survey completed by sailors, researchers at Rhode Island Hospital have ... two types of boats -- dinghies (small boats with crews ...
... , TUESDAY, Jan. 4 (HealthDay News) -- Elderly people ... dementia, researchers have found. The new study included more ... dental examination and a psychiatric assessment. Compared with participants who ... or no teeth were much more likely to have experienced ...
... patients with osteoarthritis (OA) are likely not following standard ... Researchers noted physicians were prescribing medications for pain and ... weight loss plans or exercise programs to OA patients. ... January 2011 issue of Arthritis Care & Research ...
Cached Medicine News:Health News:Obama to Sign Bill to Improve U.S. Food Safety 2Health News:Obama to Sign Bill to Improve U.S. Food Safety 3Health News:Higher Education May Benefit Some Heart Attack Patients 2Health News:Detecting esophageal cancer with light 2Health News:Watch out for that boom 2Health News:Watch out for that boom 3Health News:Clinical practitioners not adhering to evidence-based guidelines for osteoarthritis 2Health News:Clinical practitioners not adhering to evidence-based guidelines for osteoarthritis 3
(Date:8/19/2014)... Ala. , Aug. 19, 2014  The Alabama Supreme ... that patients can sue drug makers who mislead doctors into ... harmful side‑effects.  The case is Weeks v. Wyeth, and the ... makers in that same case last year. Heninger Garrison Davis ... represent the patient in the case, Danny Weeks . ...
(Date:8/19/2014)... DUBLIN , Aug. 19, 2014 ... the "Pharmaceutical Contract Manufacturing - Global Strategic Business ... This report analyzes the worldwide markets for Pharmaceutical Contract ... Injectables (Injections, Vials, and IV solutions), Solid Dosage Forms ... (Syrups, Suspensions, Gels, Creams & Ointments). The ...
(Date:8/19/2014)... , Aug. 19, 2014  AVIA – a ... task on the biggest problems in healthcare ­– announces ... Northern California , as the most recent addition ... Health will participate in AVIA,s inaugural cohort focused helping ... care and transparency among a patient,s providers so they ...
Breaking Medicine Technology:Heninger Garrison Davis Clients To Get Their Day in Court Against Brand Drug Companies 2Heninger Garrison Davis Clients To Get Their Day in Court Against Brand Drug Companies 3Heninger Garrison Davis Clients To Get Their Day in Court Against Brand Drug Companies 4Global Pharmaceutical Contract Manufacturing - Strategic Business Report 2014 2AVIA and Sutter Health Join Forces to Address Healthcare's Most Pressing Challenges 2
... Sept. 23, 2011 Henry Ford Hospital became the third ... Stimulation (DBS) procedure inside an Intraoperative Magnetic Resonance Imaging scanner, ... the neurosurgical toolbox," says Jason M. Schwalb, M.D., Director of ... "Although awake surgery with brain mapping is still ...
... Science, Inc., creators of the Basis™ B1 band, today announced ... and gaming luminaries including Kevin Colleran, Charles and Kai Huang, ... Chris Verplaetse to join the company,s executive team as vice ... launched later this year, the Basis B1 band is the ...
Cached Medicine Technology:DBS Operation for Parkinson's Disease Performed Inside iMRI 2Basis Announces Advisory Board Members from Medicine, Gaming and Social Networking 2Basis Announces Advisory Board Members from Medicine, Gaming and Social Networking 3
... Clinical Xpert™ for PDAs is a new ... Clinical Xpert puts authoritative drug, disease and ... physicians and other prescribers, nurses, pharmacists, and ... decisions at the point of care, and ...
The 3-chip MediLive Trio Eye video camera is built to adapt to changing conditions during ophthalmic surgery with features designed for workflow optimization and maximum image quality....
... A valuable new tool for ... exhibits greater dynamic range and shows ... SWAP, at the same degree of ... has been shown to correlate with ...
... The VISUCAM non-mydriatic ... quality and simplicity of ... big enough to set ... photography, it features a ...
Medicine Products: