Navigation Links
Engineered virus targets and kills apparent cancer stem cells in neuroblastoma
Date:1/20/2009

CINCINNATI After identifying an apparent population of cancer stem cells for neuroblastoma, researchers successfully used a reprogrammed herpes virus to block tumor formation in mice by targeting and killing the cells.

Published online Jan. 21 by PLoS (Public Library of Science) One, the study led by Cincinnati Children's Hospital Medical Center adds to a growing body of evidence suggesting early stage cancer precursor cells with stem-cell-like properties may explain how some cancers form, are treatment resistant and prone to relapse. The study also underscores the increasing potential of targeted biological therapies to help people with stubborn cancers like neuroblastoma, which often recur and metastasize, said Timothy Cripe, M.D., Ph.D., senior investigator and a physician/researcher in the division of Hematology/Oncology at Cincinnati Children's.

"The main finding of our study is that pediatric neuroblastomas seem to have a population of cells with stem-cell characteristics that we may need to target for therapy," Dr. Cripe said. "We also show that one promising approach for targeted treatment is biological therapy, such as an engineered oncolytic virus that seeks out and kills progenitor cells that could be the seeds of cancers."

Neuroblastoma's solid tumors usually attack the sympathetic nervous system, part of the body's autopilot mechanism that controls vital organ function and instinctive responses, like "fight or flight." The disease can be thrown into remission by chemotherapy, radiation or surgery, but it's also known for treatment resistance and a high rate of relapse and death. In patients with high-risk forms of the disease, long-term survival rates are less than 50 percent. The reasons for neuroblastoma's tendency to relapse and spread still need to be proven, said Dr. Cripe, also professor of Pediatrics at the University of Cincinnati College of Medicine.

To further explore the cancer stem cell theory
'/>"/>

Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. FDA Issues Final Regulations for Genetically Engineered Animals
2. E. coli engineered to produce important class of antibiotic, anti-cancer drugs
3. Top Athletes Join Forces for a New Mission: Athlete-Engineered Skincare to Support Performance and Benefit Charity
4. FDA Proposes Regulations for Genetically Engineered Animals
5. Tumor suppressor genes speed up and slow down aging in engineered mouse
6. OrbusNeich Receives Approval to Market Genous(TM) Bio-engineered R stent(TM) in Taiwan
7. Symposium at Angioplasty Summit TCT Asia Pacific 2008 Features OrbusNeichs Genous(TM) Bio-engineered R stent(TM)
8. Reconstructing mandibular defects with bioengineered tooth and bone
9. Nanomedicine system engineered to enhance therapeutic effects of injectable drugs
10. 5,000 Patients Treated With OrbusNeichs Genous(TM) Bio-engineered R Stent(TM) Now Enrolled in Real-Life Use Global Registry
11. T vs. B: Re-engineered human T cells effectively target and kill cancerous B cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2014)... 01, 2014 As AndroGel lawsuits and ... Ronald E. Johnson, Jr. has been appointed as co-lead ... other testosterone medications. Since the Fall of 2013, Ron ... worked diligently to investigate and prosecute the claims of ... blood clots as a result of taking testosterone. As ...
(Date:8/1/2014)... Texas (PRWEB) August 01, 2014 ... health coverage and healthcare reforms are boosting healthcare ... of medicines through discounts and increasing generic consumption ... at approximately 76.7 million in 2013, having grown ... 1.4%, from 2008. The implementation of the Health ...
(Date:8/1/2014)... 01, 2014 The "Antimicrobial Coatings ... as Zinc Oxide, Titanium Dioxide, and Zinc Omadine), ... Construction, Food & Beverages, Textiles, and others), & ... Global Trends and Forecasts to 2018" analyzes the ... opportunities, and trends in the diverse geographical regions. ...
(Date:8/1/2014)... According to new market research report "Automotive Exhaust ... & ROW), by Vehicle Type (Passenger Cars, LCVs, ... by After-Treatment Device (DPF, DOC, SCR, TWC, & ... defines and segments the global automotive exhaust systems ... all the regions, and estimates their exhaust systems ...
(Date:8/1/2014)... NY August 1, 2014 The Cardiovascular ... and first report investigations that will be presented ... scientific symposium. TCT, the world,s premier educational meeting ... September 13 17, 2014 at the Walter ... Clinical research data presented at TCT often direct ...
Breaking Medicine News(10 mins):Health News:Ron Johnson Named Co-Lead Counsel in Lawsuits for Men Injured by AndroGel and Testosterone 2Health News:Turkey Pharmaceutical and Medical Device Market Worth $21.5B & $3.3B by 2020 Respectively, Says a Report Available at MarketOptimizer.org 2Health News:Turkey Pharmaceutical and Medical Device Market Worth $21.5B & $3.3B by 2020 Respectively, Says a Report Available at MarketOptimizer.org 3Health News:Turkey Pharmaceutical and Medical Device Market Worth $21.5B & $3.3B by 2020 Respectively, Says a Report Available at MarketOptimizer.org 4Health News:Antimicrobial Coatings Market Projected to Reach $2.9 Billion by 2018 – Report by MarketsandMarkets 2Health News:Antimicrobial Coatings Market Projected to Reach $2.9 Billion by 2018 – Report by MarketsandMarkets 3Health News:Antimicrobial Coatings Market Projected to Reach $2.9 Billion by 2018 – Report by MarketsandMarkets 4Health News:Automotive Exhaust Systems Market Will Be $33,379.7 Million by 2019 – New Report by MarketsandMarkets 2Health News:Automotive Exhaust Systems Market Will Be $33,379.7 Million by 2019 – New Report by MarketsandMarkets 3Health News:Automotive Exhaust Systems Market Will Be $33,379.7 Million by 2019 – New Report by MarketsandMarkets 4Health News:CRF announces late-breaking trials and first report investigations for TCT 2014 2Health News:CRF announces late-breaking trials and first report investigations for TCT 2014 3Health News:CRF announces late-breaking trials and first report investigations for TCT 2014 4
... Inc. (AIS), publisher of industry-leading newsletters Health Plan,Week, ... pleased to announce,publication of "Managed Medicare and Medicaid ... and almost 30 million Medicaid recipients,enrolled in managed ... other,companies with a stake in this market place ...
... 21 Mylan Inc. (NYSE: MYL ),today ... approval,from the U.S. Food and Drug Administration (FDA) ... Extended-release Tablets USP, 2.5,mg, 5 mg and 10 ... generic version of,AstraZeneca Pharmaceutical,s Plendil(R) Extended-release tablets, which ...
... upcoming Public Meeting on April 22, 2008, the Centers ... input for the establishment of a Healthcare Common Procedure ... II of the HCPCS is a standardized coding system ... not included in the Current Procedural Terminology (CPT) coding ...
... -- China Medicine,Corporation (OTC Bulletin Board: CHME; ... and developer of ethical and over-the-counter drugs,traditional ... devices, and medical formulations in the PRC, ... the Guangzhou Technology Bureau to represent,Guangzhou city,s ...
... Research Group survey finds that approximately 45% of physicians, intend to ... ... years, WALTHAM, Mass., April ... at the American Academy of,Orthopedic Surgeons, annual meeting in San Francisco, CA, ...
... BRIGHTON, England, April 21 Futuremedia,Learning, a leading ... Bulletin Board: FMDAY), has launched Performance Zone, a ... health,and care organisation., The launch took place ... the,UK, with Futuremedia Learning staff on-site offering support ...
Cached Medicine News:Health News:New Medicare and Medicaid Data Released: Featuring Up-To-Date Enrollment Trends, State Initiatives, Regional Market Share and Prescription Drug Benefits 2Health News:Medicare to consider public opinion about medical maggots 2Health News:Medicare to consider public opinion about medical maggots 3Health News:China Medicine Corporation Selected to Represent Biotechnology Industry of Guangzhou City at 2008 Annual BIO International Convention 2Health News:China Medicine Corporation Selected to Represent Biotechnology Industry of Guangzhou City at 2008 Annual BIO International Convention 3Health News:Physicians Anticipate Changes in Their Usage of Hip Implants 2Health News:Futuremedia Learning Launches Next Generation Learning Portal for Bupa 2
(Date:8/1/2014)... , Aug. 1, 2014 In the ... treatments for sexual dysfunction, more than 60 doctors and ... an open letter questioning the Food and Drug Administration,s ... most common form of male sexual dysfunction compared with ... the agency to act for women by approving the ...
(Date:8/1/2014)... HAZLET, N.J. , Aug. 1, 2014 Aspire ... Customer Satisfaction Excellence Gold Star from Cisco. This designation recognizes ... the United States of America . ... culture," stated John C. Harris , President and CEO ... to our customers with their Gold Star award and are ...
(Date:8/1/2014)... 2014 MGC Diagnostics Corporation (NasdaqCM: MGCD), ... that it has completed its acquisition of MediSoft ... products based in Sorinnes, Belgium ... cardiorespiratory diagnostics market since 1977. MediSoft, a calendar ... million ($6.3 million) and incurred a net loss ...
Breaking Medicine Technology:60+ Healthcare Professionals Sign an Open Letter Urging the FDA to Approve First-Ever Drug to Treat Women's Most Common Form of Sexual Dysfunction, notes Even the Score 260+ Healthcare Professionals Sign an Open Letter Urging the FDA to Approve First-Ever Drug to Treat Women's Most Common Form of Sexual Dysfunction, notes Even the Score 3Aspire Technology Partners Recognized By Cisco For Excellence In Customer Satisfaction 2MGC Diagnostics Corporation Completes Acquisition of MediSoft SA 2MGC Diagnostics Corporation Completes Acquisition of MediSoft SA 3MGC Diagnostics Corporation Completes Acquisition of MediSoft SA 4
... 4 Shared Imaging, LLC, an independent provider of ... hospitals and healthcare providers, is excited to announce it ... Care, a nationally-recognized, prestigious gold seal of approval for ... is system-wide for its mobile MRI and PET/CT services. ...
... , LAKE FOREST, Ill., Dec. ... global specialty pharmaceutical and medication delivery company, today announced the launch ... intravenous (I.V.) medications and solutions, and now offers a complete size ... VisIV product. The launch of the 50 mL and 100 mL ...
Cached Medicine Technology:Shared Imaging Earns The Joint Commission's Accreditation for Ambulatory Health Care 2Hospira Expands VisIV(TM) Portfolio to Offer Complete Range of Environmentally Friendly I.V. Containers 2Hospira Expands VisIV(TM) Portfolio to Offer Complete Range of Environmentally Friendly I.V. Containers 3Hospira Expands VisIV(TM) Portfolio to Offer Complete Range of Environmentally Friendly I.V. Containers 4
... Ossur range of prefabricated foot and ankle ... - from ankle instability to foot malalignment. ... designs and energy-return technology., ,Age is ... ankle foot orthoses provide a measure of ...
... The Stabilizing Ankle support features ... which lock the calcaneus into ... eversion and inversion. The full-circumference ... and stability. Ideal for chronic ...
... Walker Pediatric Boot is the ... boot that offers superior comfort ... two sizes are offered thus ... will fit left or right, ...
... The Bledsoe PTB Boot is ... alternative to casting for the mid-tibia ... providing patella tendon bearing support. The ... designed for range of motion from ...
Medicine Products: