Navigation Links
Engineered Viruses Could Battle Superbugs
Date:3/4/2009

Researchers say they disabled bacterial defenses, making antibiotics more effective

WEDNESDAY, March 4 (HealthDay News) -- American researchers say they've engineered a virus that disables the defense systems of bacteria to enhance the effectiveness of antibiotics.

The scientists said this approach could help prevent bacteria from becoming resistant to antibiotics and kill bacteria that have already become antibiotic resistant.

The Massachusetts Institute of Technology and Boston University scientists engineered existing bacteriophages (viruses that infect bacteria) to attack the SOS system -- a bacterial DNA repair system that bacteria use when they're exposed to antibiotics that damage DNA -- and other gene networks in bacteria.

The survival rate for mice infected with bacteria and treated with engineered bacteriophages and antibiotics was 80 percent, compared with 50 percent for mice treated with natural bacteriophages and antibiotics, 20 percent for mice treated with antibiotics alone, and 10 percent for untreated mice.

The study was published in the March 2 online issue of the journal Proceedings of the National Academy of Sciences.

"This work lays the groundwork for the development of a library of bacteriophages, each designed to attack different bacterial targets," lead author Timothy Lu, an M.D. candidate in the Harvard-MIT Division of Health Sciences and Technology, said in an MIT news release.

Antibiotic-resistant bacteria are a serious and growing health threat. For example, methicillin-resistant Staphylococcus aureus (MRSA) causes about 94,000 infections and contributes to 19,000 deaths each year in the United States, according to the U.S. Centers for Disease Control and Prevention.

New drugs are needed to combat such superbugs, but few new antibiotics have been developed in recent decades.

"There are a lot of targets to go after, but people haven't been able to find the drugs," Lu said.

More information

The U.S. Food and Drug Administration has more about antibiotic resistance.



-- Robert Preidt



SOURCE: Massachusetts Institute of Technology, news release, March 2, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Researchers design re-engineered hospital discharge program to reduce rehospitalization
2. Engineered virus targets and kills apparent cancer stem cells in neuroblastoma
3. FDA Issues Final Regulations for Genetically Engineered Animals
4. E. coli engineered to produce important class of antibiotic, anti-cancer drugs
5. Top Athletes Join Forces for a New Mission: Athlete-Engineered Skincare to Support Performance and Benefit Charity
6. FDA Proposes Regulations for Genetically Engineered Animals
7. Tumor suppressor genes speed up and slow down aging in engineered mouse
8. OrbusNeich Receives Approval to Market Genous(TM) Bio-engineered R stent(TM) in Taiwan
9. Symposium at Angioplasty Summit TCT Asia Pacific 2008 Features OrbusNeichs Genous(TM) Bio-engineered R stent(TM)
10. Reconstructing mandibular defects with bioengineered tooth and bone
11. Nanomedicine system engineered to enhance therapeutic effects of injectable drugs
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Engineered Viruses Could Battle Superbugs
(Date:5/28/2016)... ... May 28, 2016 , ... "Color Grading media can be time consuming but ... their media," said Christina Austin - CEO of Pixel Film Studios. , With ... add stylish color grades to their footage. A LUT is a Lookup Table that ...
(Date:5/27/2016)... ... , ... Southland Log Homes , designer and manufacturer of America’s Favorite ... can be found on its website at SouthlandLogHomes.com. , The designs of the ... the craftsmanship of timber post and beam construction. The result is a barn ...
(Date:5/27/2016)... NY (PRWEB) , ... May 27, 2016 , ... This ... of a stroke, which we as a society can control and change. , As ... occurs nearly every 40 seconds within the United States. Plus, with an estimated 129,000 ...
(Date:5/27/2016)... ... May 27, 2016 , ... Aimed at nurses and employees in the health ... of leaders in the nursing and health care industry. It also provides insight to ... Christian University. , As the nursing industry is coming out of one of ...
(Date:5/26/2016)... ... May 26, 2016 , ... W.S. Badger Co. Inc ., the maker ... 2016 When Work Works Award for its use of effective workplace strategies to increase ... Works project administered by the Families and Work Institute (FWI) and the Society for ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... -- Diana Russell suffers from a form of rheumatoid arthritis ... This disease has put her in a wheelchair, and ... to leave her home.  Because of the size and ... wheelchair.  So if there is a family function, the ... to wait for the bus. Photo - ...
(Date:5/24/2016)... , May 24, 2016 Celsion ... drug development company, today provided an update on ... escalating clinical trial combining GEN-1, the Company,s DNA-based ... treatment of newly-diagnosed patients with advanced ovarian cancer ... debulking surgery.  GEN-1 is an IL-12 DNA plasmid ...
(Date:5/24/2016)... , May 24, 2016 ... de doble terapia del mundo, introduce catéteres para ... OrbusNeich, una compañía global especializada en ... vidas, ha expandido su cartera incluyendo productos para ... JADE™ y Scoreflex™ PTA son los dispositivos de ...
Breaking Medicine Technology: