Navigation Links
Engineered T cells kill tumors but spare normal tissue in an animal model
Date:4/7/2013

receptor. Mesothelin is primarily associated with mesothelioma and ovarian cancer, and a-folate receptor with ovarian cancer.

Powell likens this dual CAR approach to having two different gas pedals, one for starting the immune system and a second for revving it up. Dual CAR T cells are more selective for tumor cells since their full activity requires interaction with both antigens, which are only co-expressed on tumor cells, not normal tissue.

Dual CAR T cells showed weak cytokine production against target cells expressing only one tumor-associated antigen in lab assays, similar to first-generation CAR T cells bearing the CD3 activation domain only, but demonstrated enhanced cytokine production upon encountering natural or engineered tumor cells expressing both antigens, equivalent to second-generation CAR T cells with dual, but unseparated signaling.

In a mouse model of human ovarian cancer, T cells with the dual-signaling CARs persisted at high numbers in the blood, accumulated in tumors, and showed potent anti-cancer activity against human tumors. Dual CAR T cells were equivalent to second-generation CAR T cells in activity against tumors bearing two antigens. However, the dual-signaling CAR T cells did not react vigorously with normal tissue expressing one antigen while second- generation CAR T cells did.

"This new dual-specificity CAR approach can enhance the therapeutic efficacy of CAR T cells against cancer while minimizing reactivity against normal tissues," says Powell.

Their findings have been published in the inaugural issue of Cancer Immunology Research, the newest journal from the American Association for Cancer Research.


'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-459-0544
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Nanoparticles engineered at Notre Dame promise to improve blood cancer treatment
2. Lab-engineered muscle implants restore function in animals
3. Genetically-engineered preclinical models predict pharmacodynamic response
4. Hardwoods4less Introduces New Line of Engineered Hardwood Flooring
5. Immune cells engineered in lab to resist HIV infection, Stanford study shows
6. Selexis SA Announces Publication in Metabolic Engineering of Data Demonstrating Improvement of Therapeutic Protein Secretion with Engineered CHO Cells
7. Almost Nuts! Supports Whole Foods Decision on Banning Gentically Modified Salmon and Continues to Support the Movement Against Genetically Engineered Foods
8. New drug prevents spread of human prostate cancer cells
9. Tiny hitchhikers attack cancer cells
10. To prevent leukemias dreaded return, go for the stem cells
11. Scientists identify major source of cells defense against oxidative stress
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/4/2015)... ... 04, 2015 , ... Keeping mold top of mind is important when considering ... Mold can grow anywhere - on carpet, clothing, food, paper, and even in places ... water in the home is key to preventing mold growth, which if exposed to ...
(Date:9/4/2015)... ... September 04, 2015 , ... Many consumers are looking for a quick and convenient ... solution. , The patent-pending K Med Cups provide a quick and simple way to brew ... a cold, flu or cough. As a result, they enhance comfort and health. The invention ...
(Date:9/4/2015)... ... , ... Having access to a doctor can sometimes be a challenge for ... emergency room visits which affects hospitals’ abilities to provide quality service to those with ... to alleviate this problem has recently presented itself, the new telemedicine platform and app, ...
(Date:9/4/2015)... ... September 04, 2015 , ... Compliance ... to settlements under the Stark physician self-referral law. “Stark Law DOs and ... from Atlantic Information Services, Inc. (AIS), will detail which deals are attracting the ...
(Date:9/4/2015)... (PRWEB) , ... September 04, 2015 , ... Friday night, ... IL hosting Generation Rescue’s A Night of Hope event supporting families affected by autism, ... and Rowena and Joe Salas, joined together at the Oscar Swan Inn to support ...
Breaking Medicine News(10 mins):Health News:September is Mold Awareness Month 2Health News:September is Mold Awareness Month 3Health News:September is Mold Awareness Month 4Health News:Redesigned Packaging for Powdered Medicinal Mix Invented by InventHelp® Client (CBA-2637) 2Health News:Telemedicine Platform DocChat Announces Launch Offering a Way for Patients to Consult Doctors and Receive Prescriptions 24/7 2Health News:Telemedicine Platform DocChat Announces Launch Offering a Way for Patients to Consult Doctors and Receive Prescriptions 24/7 3Health News:Sept. 17 Webinar to Offer Best Practices for Physician Contracts 2Health News:Jenny McCarthy & Donnie Wahlberg Help Raise Over $200,000 For Generation Rescue’s ‘Night Of Hope’ Chicago Charity Event 2
... Amanda Gardner HealthDay Reporter , TUESDAY, July 19 ... women with breast cancer are undergoing chemotherapy may help prevent ... research in the July 20 issue of the Journal ... by giving the hormone triptorelin when a patient is undergoing ...
... A new study finds that it takes longer to create ... the decision, even though many of the patients in these ... decisions. When patients are incapable of deciding what should ... they are unconscious, suffering from dementia or unable to speak ...
... Sarcophaga , a fly genus, has been published by Pensoft. ... from this genus, as well as their biology, locality data ... Sarcophaga found in France and incorporates recent taxonomic ... structures in the male terminalia of all the species, and ...
... sports activities, like basketball, during childhood and adolescence can ... resulting in a deformed hip with reduced rotation and ... more likely to develop osteoarthritis than more sedentary individuals, ... Bern in Switzerland, and colleagues, whose work is published ...
... The American Society for Radiation Oncology (ASTRO) has named ... will receive their Fellow designation at a ceremony during ... 2011, at the Miami Beach Convention Center in Miami ... most revered and accomplished members of the radiation oncology ...
... July 19 (HealthDay News) -- Married men or those in ... men who are single, divorced or widowed, according to a ... that by receiving medical care sooner, married men are more ... single. The study,s findings could help inform the public about ...
Cached Medicine News:Health News:Drug May Prevent Chemo-Linked Menopause in Breast Cancer Patients 2Health News:Drug May Prevent Chemo-Linked Menopause in Breast Cancer Patients 3Health News:Do-Not-Resuscitate Orders Tougher When It's Not Patient's Call 2Health News:'Sarcophaga of France (Diptera: Sarcophaidae)' published by Pensoft 2Health News:Painful legacy of teen sports 2Health News:ASTRO announces 2011 Fellows class 2Health News:Married Men Seem to Seek Help for Heart Attacks Sooner 2
(Date:9/4/2015)... Future Prospects for Companies in Antihistamines, Corticosteroids, ... - new study showing you trends, partnerships, and ... allergic rhinitis drugs heading? What are the commercial prospects ... you potential revenues and other trends to 2025, discussing ... report provides 273 tables, charts, and graphs. Discover the ...
(Date:9/4/2015)... , Sep. 04, 2015 ... of the "Investigation Report on China,s Sodium Ibandronate Market, ... and used in the clinic under the trade name of ... Austria in 1996, sodium ibandronate was approved by ... treatment of osteoporosis under the trade name of Boniva. However, ...
(Date:9/4/2015)... -- Hutchison China MediTech Limited ("Chi-Med") ... ("HMP"), its drug R&D subsidiary, successfully achieved the ... of fruquintinib in patients with advanced non-squamous non-small ... .  The top-line results demonstrated that the ... endpoint of progression free survival ("PFS"). ...
Breaking Medicine Technology:Allergic Rhinitis Drugs Market Forecast 2015-2025 2Allergic Rhinitis Drugs Market Forecast 2015-2025 3Allergic Rhinitis Drugs Market Forecast 2015-2025 4Allergic Rhinitis Drugs Market Forecast 2015-2025 5Allergic Rhinitis Drugs Market Forecast 2015-2025 6Allergic Rhinitis Drugs Market Forecast 2015-2025 7Investigation Report on China's Sodium Ibandronate Market 2010-2019 2Second Proof-of-concept Trial of Fruquintinib Achieves its Primary Endpoint 2Second Proof-of-concept Trial of Fruquintinib Achieves its Primary Endpoint 3
... 2011 Reportlinker.com announces that a new market ... Global Blood Processing Supplies And Equipment ... This report analyzes the worldwide markets for ... by the following product segments: Blood Administration Sets, ...
... Inc. (Nasdaq: MSON ), a medical ... therapeutic, ultrasonic products worldwide for wound debridement, spinal ... surgical and medical applications, has announced a definitive ... certain selected accounts, of the BoneScalpel Ultrasonic Bone ...
Cached Medicine Technology:Global Blood Processing Supplies And Equipment Industry 2Global Blood Processing Supplies And Equipment Industry 3Global Blood Processing Supplies And Equipment Industry 4Global Blood Processing Supplies And Equipment Industry 5Global Blood Processing Supplies And Equipment Industry 6Global Blood Processing Supplies And Equipment Industry 7Global Blood Processing Supplies And Equipment Industry 8Global Blood Processing Supplies And Equipment Industry 9Global Blood Processing Supplies And Equipment Industry 10Global Blood Processing Supplies And Equipment Industry 11Global Blood Processing Supplies And Equipment Industry 12Global Blood Processing Supplies And Equipment Industry 13Global Blood Processing Supplies And Equipment Industry 14Global Blood Processing Supplies And Equipment Industry 15Global Blood Processing Supplies And Equipment Industry 16Global Blood Processing Supplies And Equipment Industry 17Global Blood Processing Supplies And Equipment Industry 18Global Blood Processing Supplies And Equipment Industry 19Global Blood Processing Supplies And Equipment Industry 20Global Blood Processing Supplies And Equipment Industry 21Global Blood Processing Supplies And Equipment Industry 22Global Blood Processing Supplies And Equipment Industry 23Global Blood Processing Supplies And Equipment Industry 24Global Blood Processing Supplies And Equipment Industry 25Global Blood Processing Supplies And Equipment Industry 26Misonix Announces Change in Distribution of BoneScalpel™ Bone Cutting System in the U.S. 2Misonix Announces Change in Distribution of BoneScalpel™ Bone Cutting System in the U.S. 3
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: