Navigation Links
Energy network within cells may be new target for cancer therapy
Date:2/21/2012

ivision cycle comes to a halt if the mitochondria are prevented from dividing. This new therapy may be especially useful in cancers which become resistant to conventional chemotherapy that directly targets the cycle."

The researchers found that the mitochondrial networks within several different lung cancer cell lines were highly fragmented, compared to normal lung cells. Cancer cells had low levels of mitofusin-2 (Mfn-2), a protein that promotes fusion by tethering adjacent mitochondria, and high levels of dynamin-related protein (Drp-1), which initiates fission by encircling the organelle and squeezing it into two discrete fragments. The Drp-1 in cancer cells also tended to be in its most active form.

The researchers tested several ways to enhance fusion and restore the mitochondrial network, both in cell culture and in animal models. They used gene therapy to increase the expression of Mfn-2, injected a small molecule (mdivi-1) that inhibits Drp-1, and used genetic techniques to block the production of Drp-1. All three interventions markedly reduced mitochondrial fragmentation, increased networking and reduced cancer cell growth.

Although the authors identify mitochondrial fission and Drp-1 activation as a potential therapeutic target in lung cancer, "this is not a cure," Archer emphasized. The treatment drastically reduced tumor size but the tumors did not completely disappear. They continued to use high levels of glucose as fuel, a hallmark of cancer metabolism that can be seen on PET scans. "This remnant could be either a central cluster of cancer stem cells," Archer said, "or an inflammatory response, the immune system infiltrating the tumor."

"Inhibiting mitochondrial fission", Archer said, "did not show any significant toxicity in mice or rats, so we are quite optimistic that our findings can lead to the development of novel, clinically feasible therapies."

The substances used to block fusion are commercially av
'/>"/>

Contact: John Easton
john.easton@uchospitals.edu
773-795-5225
University of Chicago Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Decaffeinated coffee preserves memory function by improving brain energy metabolism
2. ER Visits for Energy-Drink Ills Soar in U.S.
3. Cavemen Knew It: Cooked Meat Offers More Energy
4. Molecular depth profiling modeled using buckyballs and low-energy argon
5. Medieval Armor Drained Soldiers Energy, Study Finds
6. Energy drinks linked to substance use in musicians, study shows
7. Energy Drink-Vodka Combo Nearly Kills Teen
8. Pediatricians Group Raps Energy and Sports Drinks for Kids
9. Dual-energy CT may be useful in evaluating the severity of gout, study suggests
10. Alcohol-Energy Drink Combo Riskier Than Booze Alone, Study Says
11. US Department of Energy programs leader wins education award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/2/2015)... ... 02, 2015 , ... sweetFrog Enterprises, LLC. is pleased to announce the opening ... store located in Mississippi. The premium frozen yogurt chain was listed as #22 on ... at 104 Railroad Avenue, New Albany, MS 38652, will have a grand opening event ...
(Date:7/2/2015)... ... ... sweetFrog Enterprises, LLC. is pleased to announce the opening of its newest location ... Lone Star State. The premium frozen yogurt chain was listed as #22 on the ... July 1 at Duke’s Travel Plaza, is located at:, 30176 Hwy 64, Suite 200, ...
(Date:7/2/2015)... ... 02, 2015 , ... The American Association of Poison Control ... Overdose Stat (S.O.S.) Act of 2015 on June 23, 2015. Together with the ... decrease drug overdose – especially of heroin and opioid medication – by expanding ...
(Date:7/2/2015)... ... 02, 2015 , ... Many Fourth of July celebrations will include fireworks this ... is sharing some tips to promote the proper use of fireworks. , According ... emergency room daily with fireworks-related injuries in the month surrounding the Fourth of July. ...
(Date:7/2/2015)... ... ... Patrick Achebe realized that the gift of poetry was fully in him, as beautiful phrases ... and three years later he was publishing an entire book of poetry. He knew there ... have always believed that the best way to lift yourself up, is in the effort ...
Breaking Medicine News(10 mins):Health News:sweetfrog Opens First Location in Mississippi 2Health News:sweetFrog Expands Texas Footprint with Location in Canton 2Health News:AAPCC Supports the Stop Overdose Stat Act of 2015 2Health News:AAPCC Supports the Stop Overdose Stat Act of 2015 3Health News:6 Fireworks Safety Tips from Amica Insurance 2Health News:Patrick Achebe Releases Debut Book, Whispering Waves: Poems for Everyday Grace 2
... OAKS, Calif., May 28 Though most people are pulling ... the rule is insurance-covered treatments, like laser vein ... their varicose veins removed do not even realize that beautiful, ... covers the procedure. By not having varicose veins ...
... Chemical , one of the leading manufacturers of ... announced it plans to expand its sucralose capacity to ... next three years. The company also has the ... metric tons by 2014.(Logo: http://www.newscom.com/cgi-bin/prnh/20090528/CG23830LOGO )"Due to ...
... of Kerry Teel as President of Premier Anesthesia, a national anesthesia ... ... GA (Vocus) May 28, 2009 -- Jackson Healthcare announces ... national anesthesia management company based in Atlanta, Georgia., , , , ...
... StemCyte, Inc., a privately held cord blood bank ... 1,000th cord blood stem cell shipment for transplant. ... growth as one of the world,s leading providers ... http://www.newscom.com/cgi-bin/prnh/20090528/NY23885LOGO ...
... took a major step forward to save lives and ... $1 per pack surcharge into law. Additionally, the governor ... smoking cessation services for Floridians, including monies for the ... fourth lowest in the nation. When the surcharge goes ...
... Form Coalition to Mobilize Support for Local LTC EconomiesWASHINGTON, ... designed and launched this week as the voice and ... that support the long term care industry by providing ... of the nation,s elderly, announced today its opposition to ...
Cached Medicine News:Health News:Get Sexy Summer Legs From Renaissance Laser and Vein Institute (laserandveinclinic.com) Courtesy of Your Health Insurance 2Health News:Niutang to Expand Sucralose Capacity 66 Percent by 2012 2Health News:Kerry Teel Named President of Premier Anesthesia 2Health News:Kerry Teel Named President of Premier Anesthesia 3Health News:StemCyte, Inc. Reaches 1,000th Cord Blood Stem Cell Shipment for Transplant Milestone 2Health News:Florida's $1 Cigarette Tax Increase a Big Win for Public Health 2Health News:Florida's $1 Cigarette Tax Increase a Big Win for Public Health 3Health News:Community Businesses Impacted by Looming Cuts to Long Term Care Federal Funding 2Health News:Community Businesses Impacted by Looming Cuts to Long Term Care Federal Funding 3Health News:Community Businesses Impacted by Looming Cuts to Long Term Care Federal Funding 4
(Date:7/2/2015)... , July 2, 2015 /PRNewswire/ - ESSA Pharma Inc. ("ESSA" ... shares have been approved for listing and trading on the ... ESSA will begin trading on NASDAQ on July 9, 2015.  ... Exchange under the symbol "EPI". As a result ... each of the Company,s outstanding special warrants issued on January ...
(Date:7/2/2015)... July 2, 2015  Fort Lauderdale-based investment banking ... announce that its Consumer Group completed the sale ... Group plc (ISE: KRZ) ("Kerry"), one of the ... systems, as well as functional ingredients and actives ... Farlie Turner served as the exclusive financial advisor ...
(Date:7/2/2015)... NEW YORK , July 2, 2015 /PRNewswire/ ... of a conspicuously high-growth market segment in hematology ... research publisher said that Roche,s recent unveiling of its ... into the cobas m 511 hematology ... not only capture growth enjoyed by current leader ...
Breaking Medicine Technology:ESSA Pharma Inc. to Commence Trading on the NASDAQ Capital Market 2ESSA Pharma Inc. to Commence Trading on the NASDAQ Capital Market 3ESSA Pharma Inc. to Commence Trading on the NASDAQ Capital Market 4Farlie Turner's Consumer Group Completes Sale of Insight Beverages to Kerry 2Kalorama: With Bloodhound, Roche Closes in on High-Growth Hematology Segment 2Kalorama: With Bloodhound, Roche Closes in on High-Growth Hematology Segment 3
... percent of patients treated with VELCADE, cyclophosphamide,and ... Greece, June 28, 2007 /PRNewswire-FirstCall/ -- Millennium,Pharmaceuticals, ... results,from clinical trials of VELCADE based therapies ... (CR) rates in previously,treated multiple myeloma (MM) ...
... 29, 2007 /PRNewswire/ --,The European Myeloma Platform (EMP) ... (lenalidomide) plus the,steroid dexamethasone shows median survival of ... from two large randomized,controlled Phase III trials that ... sites worldwide. These updated results,were presented at the ...
Cached Medicine Technology:Velcade (Bortezomib) for Injection Based Therapies Produced,Complete Remission Rates as High as 54 Percent in Patients With,Previously Treated Multiple Myeloma 2Velcade (Bortezomib) for Injection Based Therapies Produced,Complete Remission Rates as High as 54 Percent in Patients With,Previously Treated Multiple Myeloma 3Velcade (Bortezomib) for Injection Based Therapies Produced,Complete Remission Rates as High as 54 Percent in Patients With,Previously Treated Multiple Myeloma 4Velcade (Bortezomib) for Injection Based Therapies Produced,Complete Remission Rates as High as 54 Percent in Patients With,Previously Treated Multiple Myeloma 5Velcade (Bortezomib) for Injection Based Therapies Produced,Complete Remission Rates as High as 54 Percent in Patients With,Previously Treated Multiple Myeloma 6The European Myeloma Platform Reports New Survival data for,Revlimid Presented at the International Myeloma Workshop in Greece 2
... RM2125 microtome comes in two different versions ... RT. All RM2125 versions are now equipped ... the precision micrometer feeding system. The Leica ... function and specimen retraction as additional features. ...
... microtome with automatic fine/trim- feed system, ... precision cross roller bearings. For sectioning ... in biological, botany, and materials science. ... 90 mm can be accommodated. Performance, ...
... EC 350 consists of two modular units. ... surface and reaches a temperature of -15C. ... reservoir, heated dispenser nozzle, heated work surface, ... separate heated compartments for molds and cassettes. ...
... Infusion Catheter enables the physician to isolate ... and disperse the agent by means of ... is a multi-lumen catheter with two (2) ... infusion holes located between these balloons. When ...
Medicine Products: