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Ends of chromosomes protected by stacked, coiled DNA caps
Date:4/20/2011

ome G4 DNA may help cap telomeres, but too much G4 DNA or formation of G4 DNA at the wrong times or places may be detrimental. G4 DNA is not a single thing, but is rather a family of related structures, and so it might be possible to target particular types of G4 DNA to, for example, improve telomere capping in normal cells or disrupt the growth of cancer cells. This is a very new field, and it will be fun to see how far it might go."

This study was supported by grants from the National Institute on Aging. The lead author, Jasmine S. Smith, PhD performed this study as part of her Ph.D. dissertation research, which grew from studies begun by the second author, Qijun Chen, PhD. Dr. Liliya Yatsunyk's lab at Swarthmore College performed many of the studies on G4 DNA structure.


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Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

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