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Endoscopic ultrasound evaluation is associated with improved outcomes in pancreatic cancer patients
Date:7/8/2010

ve, and can be used to determine the stage of cancers. Tissue samples, using a fine needle aspiration technique (FNA), can be obtained in real time with EUS guidance should an abnormality be seen.

"We hypothesized that undergoing EUS was associated with improved overall survival in pancreatic cancer patients, probably related to early pancreatic cancer detection and accurate preoperative staging by EUS and improved stage-appropriate treatment," said study lead author Saowanee Ngamruengphong, MD, Mayo Clinic Arizona, Scottsdale. "In this study, we analyzed the Surveillance Epidemiology and End Results (SEER) Medicare-linked database to study the association of undergoing EUS with overall survival in a cohort of patients with pancreatic adenocarcinoma and found that EUS is associated with improved survival in pancreatic cancer patients, most probably as a result of improved stage-appropriate management, including more selective performance of curative intent surgery and perioperative adjuvant therapy."

Patients and Methods

Using the SEER-Medicare database, researchers identified a total of 8,616 patients aged 65 and older with primary pancreatic cancer from January 1994 to December 2002 who fulfilled the inclusion and exclusion criteria. The study population was divided into two groups based on whether or not they underwent EUS evaluation. Group I consisted of patients who underwent EUS during the peridiagnostic period, Group II did not undergo EUS. Overall, 610 patients or 7.1 percent, underwent EUS for tumor evaluation and staging.

Results

There were more patients with early-stage disease in Group I than in Group II, 69.3 percent locoregional (localized and regional stage) disease in Group I vs. 36.2 percent in Group II. Curative-intent surgery, chemotherapy and radiation therapy were also performed more frequently in Group I. In patients with locoregional pancreatic adenocarcinoma, the median survival in Gr
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Contact: Anne Brownsey
abrownsey@asge.org
630-570-5635
American Society for Gastrointestinal Endoscopy
Source:Eurekalert

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