Navigation Links
Endometriosis risk linked to 2 pesticides
Date:11/4/2013

SEATTLE A Fred Hutchinson Cancer Research Center-led study has found that two organochlorine pesticides are associated with an increased risk of endometriosis, a condition that affects up to 10 percent of reproductive-age women.

Specifically, researchers observed that women with higher exposures to two such pesticides, beta-hexachlorocyclohexane and mirex, had a 30- to 70-percent increase in endometriosis risk.

The findings are published online ahead of the print issue of Environmental Health Perspectives, a journal of the National Institute of Environmental Health Sciences, part of the National Institutes of Health.

Endometriosis is a noncancerous condition that occurs when the tissue that lines the inside of the uterus, or womb, grows outside of the organ and attaches to other structures or organs. The condition most often affects the ovaries, fallopian tubes and lining of the pelvic cavity. The most common symptoms include chronic pelvic pain, painful menstrual periods and infertility.

"For many women, the symptoms of endometriosis can be chronic and debilitating, negatively affecting health-related quality of life, personal relationships and work productivity," said lead and corresponding author Kristen Upson, Ph.D., who was a predoctoral research fellow in epidemiology at Fred Hutch and the University of Washington when the study was conducted. Today she is a postdoctoral fellow at the Epidemiology Branch of the NIEHS.

"Since endometriosis is an estrogen-driven condition, we were interested in investigating the role of environmental chemicals that have estrogenic properties, such as organochlorine pesticides, on the risk of the disease," she said.

The principal investigator of the study was Victoria Holt, Ph.D., a joint member of the Epidemiology Research Unit in the Public Health Sciences Division at Fred Hutch and professor of epidemiology at the University of Washington School of Public Health.

"This research is important, as endometriosis is a serious condition that can adversely affect the quality of a woman's life, yet we still do not have a clear understanding of why endometriosis develops in some women but not in others," Holt said. "Our study provides another piece of the puzzle."

The study was conducted among members of Group Health Cooperative, a Seattle-based nonprofit health care system. The study involved 248 women newly diagnosed with endometriosis and, for comparison, 538 women without the disease.

"We found it interesting that despite organochlorine pesticides being restricted in use or banned in the U.S. for the past several decades, these chemicals were detectable in the blood samples of women in our study and were associated with increased endometriosis risk," Upson said. "The take-home message from our study is that persistent environmental chemicals, even those used in the past, may affect the health of the current generation of reproductive-age women with regard to a hormonally driven disease."

Organochlorine pesticides have generally demonstrated estrogenic properties in laboratory studies of human tissue and adverse reproductive effects in laboratory studies of other model organisms, altering the function of the uterus and ovaries, as well as hormone production.

"Given these actions, it's plausible that organochlorine pesticides could increase the risk of an estrogen-driven disease such as endometriosis," Upson said. "We hope our findings will help inform current global policymaking to reduce or eliminate their use."


'/>"/>

Contact: Kristen Woodward
media@fredhutch.org
206-667-2210
Fred Hutchinson Cancer Research Center
Source:Eurekalert  

Related medicine news :

1. Endometriosis Bible & Violet Protocol Review and Price Analysis Released by Daily Gossip
2. Dr. Tamer Seckin Comments on the Effects of Endometriosis on Miscarriages and Infertility
3. Global Endometriosis Market Analysis and 2022 Forecasts in New Research Report at RnRMarketResearch.com
4. Irregular Menses and Pain Caused by Adenomyosis or Endometriosis Can Be Improved with Herbal Therapy without Pain Killers & Surgeries - Wuhan Dr. Lee’s TCM Clinic
5. Carolina Women's Physicians Raised Awareness During Endometriosis Month
6. Endometriosis treatments lower ovarian cancer risk
7. Another Painful Period…or a Problem? Understanding Endometriosis
8. Da Vinci Robotic Procedure Offers a Surgical Solution for Endometriosis; Now Available at Women’s Excellence in Endometriosis in Oakland County, Michigan
9. Dr Jonathan Zaidan Opens State-of-the-Art Specialty Center, Women’s Excellence in Endometriosis, Featuring Electronic Medical Records and E-prescribing, near Pontiac, MI
10. Women’s Excellence in Endometriosis Now Open in Lake Orion, Michigan – Dr. Jonathan Zaidan MD Opens Private Center to Treat the Most Complicated Cases of Endometriosis
11. Dr. Jonathan Zaidan MD and Debbie Henry NP-C Collaborate to Provide Pelvic Pain Management at Women’s Excellence in Endometriosis near Rochester, MI
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Endometriosis risk linked to 2 pesticides
(Date:9/19/2017)... ... September 19, 2017 , ... Public outrage over the toxins that exist ... deaf ears, leaving the water industry itself to research, develop and ultimately supply consumers ... curve in the field of natural alkaline water technologies, water filtration ...
(Date:9/19/2017)... ... September 19, 2017 , ... ... the launch of its magnesium-based orthopedic medical device, OsteoCrete®. OsteoCrete® bone void filler ... in the U.S. to incorporate magnesium, a critical property for bone health and ...
(Date:9/19/2017)... (PRWEB) , ... September 19, 2017 , ... Ron Norman, ... candidates today the importance of making a distinct rather than generic impression in the ... had to look through a stack of resumes knows that the first impression they ...
(Date:9/19/2017)... ... September 19, 2017 , ... ... to the Certified Emergency Nurse (CEN®) certification according to a large-scale ... value of certification study, conducted by the Human Resources Research Organization (HumRRO) in ...
(Date:9/18/2017)... , ... September 18, 2017 , ... A September 7 ... in Belfast indicating that aspirin, one of the world’s most common and least expensive ... Los Angeles area dentist Dr. Farzad Feiz of California Dental Group and Calabasas Dental ...
Breaking Medicine News(10 mins):
(Date:9/18/2017)... Sept. 18, 2017 EpiVax, Inc. ... bioinformatics and immune engineering, today announced a ... A (H7N9) vaccine. ... seasonal influenza and presents a challenge for ... exposure to be effective. Using state-of-the-art bioinformatics and ...
(Date:9/12/2017)... , Sept. 12, 2017  Consumer reviews on the independent ... as the number one company for hearing aids, ranking it ... fifteen other brands. ... Hearing Named #1 by Consumers For Hearing Aids ... Embrace Hearing is an online store that provides high performance, ...
(Date:9/9/2017)... Sept. 8, 2017 Dealmed Medical Supplies, ... of medical equipment, supplies, drugs, vaccines, and specialty medical ... into an agreement to acquire Vantage Medical Supplies, a ... Holtsville, New York . ... new and emerging medical practices, will operate under the ...
Breaking Medicine Technology: