Navigation Links
Endometrial and acute myeloid leukemia cancer genomes characterized
Date:5/1/2013

elations between histology and genomic data may not have been observed or potential clinical outcomes identified."

With a complete analysis of the study's findings, investigators have identified four novel genomic-based subtypes of endometrial cancer, which may set the stage for new diagnostic and treatment approaches. Each of the four genomic subtypes clustered together and was named for one of its notable characteristics:

The POLE ultramutated group was named for its unusually high mutation rates and hotspot mutations (sequences highly susceptible to mutation) in the POLE gene. The hypermutated microsatellite instability group exhibited a high mutation rate, as well as few copy number alterations, but did not carry mutations in the POLE gene. The copy number low group showed the greatest microsatellite stability but a high frequency of mutations in CTNNB1, a gene critical for maintaining the linings of organs, such as the endometrium. The copy number high subtype was composed of mostly serous tumors, but included some endometrioid samples. This subtype displayed copy number alterations and a mutation landscape that was characteristic of serous tumors.

Endometrial cancer is the fourth most commonly diagnosed cancer among women in the United States. NCI estimates that close to 50,000 women will be diagnosed with endometrial cancer in 2013, with more than an estimated 8,000 deaths from the disease. For a majority of patients diagnosed with aggressive, high grade tumors with metastases, the five-year survival rate is about 16 percent, though chemotherapy has been associated with an improvement in survival, and new targeted agents are being tested.

"Finding genomic similarities among types of breast, ovarian, endometrial and colorectal tumors once again reveals that cancer, although very complex, may have themes extending beyond tissue type that can be exploited for therapeutic benefit," said Eric D. Green, M.
'/>"/>

Contact: NCI Press Office
ncipressofficers@mail.nih.gov
301-496-6641
NIH/National Cancer Institute
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9

Related medicine news :

1. Keeping Fit May Boost Survival With Endometrial Cancer
2. Childbirth After 30 Lowers Risk of Endometrial Cancer: Study
3. Women who give birth after age 30 lower their risk of endometrial cancer
4. Nephrologist follow-up improves mortality of severe acute kidney injury patients
5. Frequently used biologic agents might cause acute liver injury
6. American College of Physicians unveils tools to improve acute coronary syndrome care
7. Avamere Family of Companies Acquires Six Transitional Care Facilities, Expands Eastward into New Post-Acute Markets.
8. Acute stroke therapy used 3 times more at certified primary stroke centers
9. High-Dose Statins Linked to Acute Kidney Damage
10. Newly incarcerated have 1 percent acute hepatitis C prevalence
11. Mortality for acute aortic dissection near 1 percent per hour during initial onset
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... December 25, 2014 Residents at ... Community, recently showed their generous spirit by providing ... Catawba County Parenting Network- Grandparents Raising Grandchildren program. ... gathered around the largest Christmas tree on the ... purchased by residents of the Abernethy Village Association ...
(Date:12/24/2014)... (PRWEB) December 25, 2014 Over 700 ... to their local communities. That is 700 smiling little ... single gift. Additionally over $6000 in monetary donations was ... offset some of the expenses they incur through the ... drive were A Child's Haven , Shrine's Children's ...
(Date:12/24/2014)... York (PRWEB) December 24, 2014 Risperdal ... in a mass tort litigation currently underway in Pennsylvania’s ... As of December 24, 2014, court documents indicate ... on behalf of individuals who developed gynecomastia (male breast ... Data from the Court indicates that this represents an ...
(Date:12/24/2014)... 25, 2014 Today, UWDress.com, the famous women’s ... wedding gowns, and launched a site-wide wedding gown promotion. ... wedding gowns in a more unexpected way, the collection should ... popular in the global market, and they are available with ... are offered at discounted prices, up to 75% off; most ...
(Date:12/24/2014)... BambooIndustry.com a famous bamboo flooring company offering bamboo flooring ... announces its multiple layer bamboo panel board collection , ... , Bamboo panel is the product made from 100 ... board features high quality selective bamboo and eco-friendly adhesives ... panel consists of multiple layers of bamboo. , According ...
Breaking Medicine News(10 mins):Health News:Retirement Community Residents Make Impact During Holiday Season 2Health News:AlignLife Donates Over 700 Toys This Year 2Health News:Risperdal Lawsuits Continue to Climb, as Claims in Pennsylvania Litigation Exceed 1,180 Filings, Bernstein Liebhard LLP Reports 2Health News:Risperdal Lawsuits Continue to Climb, as Claims in Pennsylvania Litigation Exceed 1,180 Filings, Bernstein Liebhard LLP Reports 3Health News:Risperdal Lawsuits Continue to Climb, as Claims in Pennsylvania Litigation Exceed 1,180 Filings, Bernstein Liebhard LLP Reports 4Health News:Buy Cheap Long Sleeve Wedding Gowns At UWDress.com 2Health News:Bamboo Flooring Company Bambooindustry.com Introduces Its Multiple Layer Bamboo Panel Board Collection 2
... Inherent gender differences – instead of more sun exposure – ... likely than women to develop// certain kinds of skin cancer, ... ,Squamous cell carcinoma is the second most common form of ... United States each year. While occurring more often than melanoma, ...
... key challenge in the development of vaccines for bird flu, ... strain //of bird flu, the H5N1 virus, which could mutate ... nations in the world have continually exchanged information with the ... the motive of assisting scientists to be abreast with the ...
... breastfeeding a baby till it is six months old ... say//. ,The Human Immunodeficiency Virus (HIV) ... immune system begins to fail. ,Hoosen Coovadia ... and Population Studies at the University of KwaZulu-Natal, South ...
... supports the theory that bringing about senescence in aged ... ,Inducing senescence in aged cells may be sufficient to ... published online this week in European Molecular Biology Organization ... or programmed cell death – apoptosis – was the ...
... the University of Florida have initiated a project to ... secrets of regeneration from creatures with remarkable powers of ... ,Fueled by about $6 million in private donations, university ... connect scientists who work with adult human stem cells ...
... FDA launched a special Web page. This web page is ... sold by Roche// under the brand name Accutane, on the ... that is not controlled by other treatment forms. FDA warns ... severe mental health problems. ,The FDA warning page ...
Cached Medicine News:Health News:Gender Linked to Development of Skin Cancer 2Health News:Gender Linked to Development of Skin Cancer 3Health News:Breastfeeding Could Cut HIV Risk to Babies 2Health News:UF Launches Project to Bridge the Regeneration Gap 2Health News:UF Launches Project to Bridge the Regeneration Gap 3Health News:Web Page to Warn Against Online Purchase of Isotretinoin 2
(Date:12/22/2014)... 2014  CytoSorbents Corporation (OTCQB:CTSOD), a critical care ... technology to help fight deadly inflammation in critically-ill ... today announced the appointment of Dr. Gregory ... Senior Vice President of Clinical Development, effective January ... Russo is an accomplished pediatric cardiothoracic surgeon ...
(Date:12/22/2014)... 22, 2014 Research and Markets ( ... "US Self-monitoring Blood Glucose Market" report to their ... This market insight focuses on the developments in ... United States . Reimbursement analysis and the effects ... for more than 73 SMBG meters have been performed, ...
(Date:12/22/2014)... a privately-held medical products and technologies company, today announced ... Officer of the company, effective December 22, 2014. ... Board of Directors of ConvaTec thanks Mr. Berger for ... years," said Magnus Lundberg , the Chairman of ... company is well positioned for the future."  The company ...
Breaking Medicine Technology:CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 2CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 3CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 4CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 5US Self-monitoring Blood Glucose Market 2ConvaTec Names Paul Moraviec Interim CEO Effective December 22, 2014 2
... , , , , ... The Heart Failure Society of America,s (HFSA) 13th Annual ... in Boston. This three-day meeting -- a forum for heart failure specialists ... trends in research and new developments in the approach to treating patients ...
... , , , ... AMGN ) today announced the presentation of data highlighting ... reduction among women with postmenopausal osteoporosis. The data were presented at ... Research (ASBMR). , , "These data enhance our ...
Cached Medicine Technology:Heart Failure Society of America 13th Annual Scientific Meeting to Focus on a Bench-To-Bedside Approach 2Heart Failure Society of America 13th Annual Scientific Meeting to Focus on a Bench-To-Bedside Approach 3Data Show Medication Adherence is an Important Factor in the Treatment of Postmenopausal Osteoporosis 2Data Show Medication Adherence is an Important Factor in the Treatment of Postmenopausal Osteoporosis 3Data Show Medication Adherence is an Important Factor in the Treatment of Postmenopausal Osteoporosis 4Data Show Medication Adherence is an Important Factor in the Treatment of Postmenopausal Osteoporosis 5Data Show Medication Adherence is an Important Factor in the Treatment of Postmenopausal Osteoporosis 6Data Show Medication Adherence is an Important Factor in the Treatment of Postmenopausal Osteoporosis 7Data Show Medication Adherence is an Important Factor in the Treatment of Postmenopausal Osteoporosis 8Data Show Medication Adherence is an Important Factor in the Treatment of Postmenopausal Osteoporosis 9
... Cross-match tubes are available ... serum tube contains a clotting ... cross-match tests where serum is ... EDTA cross-match tube is suitable ...
Inquire...
... K2 / gel tubes are for ... molecular diagnostics and for viral load ... blood remain stable at room temperature ... optimal results, it is recommended to ...
Glass Whole Blood Tube with K3EDTA...
Medicine Products: