Navigation Links
Emotional stress reduces effectiveness of prostate cancer therapies in animal model
Date:1/25/2013

WINSTON-SALEM, N.C. Jan. 25, 2013 Not surprisingly, a cancer diagnosis creates stress. And patients with prostate cancer show higher levels of anxiety compared to other cancer patients.

A new study by researchers at Wake Forest Baptist Medical Center indicates that stress is not just an emotional side effect of the diagnosis; it also can reduce the effectiveness of prostate cancer drugs and accelerate the development of prostate cancer.

The findings are published in the February issue of the Journal of Clinical Investigation.

The Wake Forest Baptist team, headed by George Kulik, D.V.M., Ph.D., associate professor of cancer biology, tested the effects of behavioral stress in two different mouse models of prostate cancer.

One model used mice that were implanted with human prostate cancer cells and treated with a drug that is currently in clinical trial for prostate cancer treatment. When the mice were kept calm and free of stress, the drug destroyed prostate cancer cells and inhibited tumor growth. However, when the mice were stressed, the cancer cells didn't die and the drug did not inhibit tumor growth.

In the second model, mice genetically modified to develop prostate cancer were used. When these mice were repeatedly stressed, the size of prostate tumors increased. When the mice were treated with bicalutamide, a drug currently used to treat prostate cancer, their prostate tumors decreased in size. However, if mice were subjected to repeated stress, the prostate tumors didn't respond as well to the drug.

After analyzing the data, the Wake Forest Baptist researchers identified the cell signaling pathway by which epinephrine, a hormone also known as adrenaline, sets off the cellular chain reaction that controls cell death. Considering that prostate cancer diagnosis increases stress and anxiety levels, stress-induced activation of the signaling pathway that turns off the cell death process may lead to a vicious cycle
'/>"/>

Contact: Marguerite Beck
marbeck@wakehealth.edu
336-716-2415
Wake Forest Baptist Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers map emotional intelligence in the brain
2. Emotional disconnection disorder threatens marriages, researcher says
3. Meditation appears to produce enduring changes in emotional processing in the brain
4. Pacifiers may have emotional consequences for boys
5. Chronic Pain May Depend on Emotional Reaction to Injury
6. Author and Speaker Dr. Yvonne Corppetts to Lecture on Creating A Healthy Workplace (Emotionally)
7. Emotional Woes May Last for Childhood Cancer Survivors
8. Gatekeeper of brain steroid signals boosts emotional resilience to stress
9. Online Dating Scams Can Take Emotional, Financial Toll
10. SMART heart eases heart ache, targets cardiac patients emotional well-being
11. Emotional Trauma May Hurt Toddlers Later Learning
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 22, 2015 Liberty University has received accreditation ... program from the Council for Accreditation of Counseling & ... Liberty’s Center for Counseling & Family Studies , is ... the university’s new School of Behavioral Sciences. Prior to the ...
(Date:1/22/2015)... AZ (PRWEB) January 22, 2015 Padre Murphy's ... long supporter of Pro Player Health Alliance (PPHA). ... Padre Murphy's in getting everyone, including NFL greats, treated for ... of the leading groups supporting the cause in the valley. ...
(Date:1/22/2015)... 2015 AngelWeddingDress, the premier women’s dress ... wedding dresses. View website of AngelWeddingDress.com to ... maternity wedding dresses online for a bridal party. AngelWeddingDress ... quality for them. Its maternity wedding dresses are specially ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Autocarinsurancebest.com has released ... purchasing a commercial auto insurance policy . , Auto ... their vehicles. It is no longer necessary to call an ... are now available online on a single website: http://autocarinsurancebest.com/ ...
(Date:1/22/2015)... Yesterday, Senator Holly Mitchell (D-Los ... Olsen (R-Modesto) were honored by the California Healthcare ... biomedical science, medical device and pharmaceutical innovation in ... “2014 Life Sciences Champion” award from CHI President ...
Breaking Medicine News(10 mins):Health News:Liberty University's Resident Master’s Counseling Program Receives CACREP Accreditation 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 3Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2Health News:Commercial Auto Insurance Provides Several Important Features! 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3
... Corporation (Nasdaq: PRXL ), a leading global ... established The Expert Office(TM) at PAREXEL. ... single point of contact for clients to more ... Company,s leading medical, therapeutic area, regulatory, and clinical ...
... ... ClearCanvas customer base of more than 5,000 radiology software users worldwide. , ... Toronto, Ontario (PRWEB) November 5, ... provider for ClearCanvas, Inc. open source RIS/PACS products. Oso Healthcare will provide ...
... , ... Houston dermatologist with offices in New York and Texas, is launching a powerful new website ... The Ultimate Guide To Better Skin, Dr. Friedman is using his website as an educational resource ... ...
... , ... portal and a potent time for co-creation of the highest good. Join a Worldwide 11/11 ... date, come together as a human family to envision a world of love that works for ... Nevada City, CA (PRWEB) November ...
... ... Solutions, Inc. a leader in healthcare outsourcing, today announced that it has completed its ... of medical documentation and workflow management software based in Marietta, Georgia. , ... Plano, TX (PRWEB) November 5, ...
... Nov. 5 The American Legislative ... association of state legislators, congratulates Montana State Senators ... for announcing their intent to introduce a constitutional amendment ... health care choices. Montana now becomes the 20th state where ...
Cached Medicine News:Health News:PAREXEL Introduces The Expert Office(TM) -- Offering Enhanced Access to Comprehensive Expertise to Meet Strategic Partnering Needs 2Health News:PAREXEL Introduces The Expert Office(TM) -- Offering Enhanced Access to Comprehensive Expertise to Meet Strategic Partnering Needs 3Health News:PAREXEL Introduces The Expert Office(TM) -- Offering Enhanced Access to Comprehensive Expertise to Meet Strategic Partnering Needs 4Health News:PAREXEL Introduces The Expert Office(TM) -- Offering Enhanced Access to Comprehensive Expertise to Meet Strategic Partnering Needs 5Health News:Oso Healthcare Provides Implementation and Support Services for ClearCanvas Open Source RIS/PACS 2Health News:Oso Healthcare Provides Implementation and Support Services for ClearCanvas Open Source RIS/PACS 3Health News:Oso Healthcare Provides Implementation and Support Services for ClearCanvas Open Source RIS/PACS 4Health News:Houston and New York Cosmetic Dermatologist Paul M. Friedman, MD Launches Expansive New Website 2Health News:Houston and New York Cosmetic Dermatologist Paul M. Friedman, MD Launches Expansive New Website 3Health News:November 11 at 11:11 Join a Worldwide Meditation for the Divine Feminine and Envision a World that Works for All 2Health News:Superior Global Solutions, Inc. Acquires HTI Technologies, Inc. 2Health News:Superior Global Solutions, Inc. Acquires HTI Technologies, Inc. 3Health News:Montana Now 20th State to Defend Health Care Choice 2
(Date:1/23/2015)... Jan. 23, 2015  Today the U.S. Food and Drug ... the prevention of serogroup B meningococcal disease ... vaccine Trumenba®, which received FDA approval in October, represent ... disease. "I have heard over and ...
(Date:1/23/2015)... 23, 2015 Research and Markets ( http://www.researchandmarkets.com/research/5dh22x/urinary_catheters ... Catheters Market (Indwelling or Foley Catheters, Intermittent Catheters and ... Size, Share, Growth, Trends and Forecast 2014 - 2020" ... At present, the global market for urinary catheters is ...
(Date:1/23/2015)... BETHESDA, Md. , Jan. 23, 2015  Northwest Biotherapeutics, Inc. ... developing DCVax® personalized immune therapies for operable and inoperable solid ... will present at the 7 th Annual Phacilitate Immunotherapy ... NW Bio,s presentation at Phacilitate will take place on January ...
Breaking Medicine Technology:The National Meningitis Association (NMA) Applauds FDA Approval of Second Vaccine To Protect Against Serogroup B Meningococcal Disease 2Urinary Catheters Market (Indwelling or Foley Catheters, Intermittent Catheters and Male External or Condom Catheters) - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Urinary Catheters Market (Indwelling or Foley Catheters, Intermittent Catheters and Male External or Condom Catheters) - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3NW Bio To Present At The 7th Annual Phacilitate Immunotherapy Forum 2NW Bio To Present At The 7th Annual Phacilitate Immunotherapy Forum 3
... 2011 ChromaDex® Corp. (OTCBB: CDXC) today announced ... ChromaDex® the exclusive rights to a joint patent ... the method of inducing UDP-glucuronosyltransferase (UGT) activity using ... found in blueberries and demonstrated to have multiple ...
... Sept. 8, 2011 Abaxis, Inc. (NasdaqGS: ABAX), a ... today that Clint Serverson, chief executive officer,  will present ... Tuesday, September 13, 2011 at 10:20 a.m. ET at ... AbaxisAbaxis develops, manufactures, markets and sells portable blood analysis ...
Cached Medicine Technology:ChromaDex®'s Novel Ingredient pTeroPure® to be Studied as Potential Treatment for Fighting Skin Cancers 2ChromaDex®'s Novel Ingredient pTeroPure® to be Studied as Potential Treatment for Fighting Skin Cancers 3Abaxis to Present at 2011 Morgan Stanley Global Healthcare Unplugged Conference 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: