Navigation Links
Emory study of syphilis bacteria yields valuable diagnostic tool
Date:6/13/2008

Variations in a gene within the family of bacteria that causes syphilis may hold clinical, epidemiological and evolutionary significance, researchers at Emory University in Atlanta have found.

The researchers' study results describe how sequence variations they identified in the acidic repeat protein (ARP) gene allow straightforward differentiation of venereal syphilis from non-venereal Treponema pallidum subspecies. The study was published online in the journal FEMS Immunology and Medical Microbiology June 12 (http://www.blackwell-synergy.com/doi/abs/10.1111/j.1574-695X.2008.00427.x).

"This finding can lead to improved diagnoses of cases, enabling doctors to prescribe the right treatment, and public health workers to determine the best prevention strategies," says Kristin Harper, who led the research team as a Howard Hughes Medical Institute pre-doctoral fellow in Emorys Population Biology, Ecology and Evolution program.

The family of Treponema bacteria causes venereal syphilis and the non-venereal diseases of yaws and bejel, which are transmitted through skin-to-skin or oral contact. Public health workers in parts of Africa have reported difficulty in distinguishing yaws from syphilis in children, leaving open the question of whether the child may have contracted a venereal disease either congenitally or through sexual abuse.

"As yaws eradication efforts near their goal, and case diagnosis becomes more difficult due to the relative rarity of yaws, a molecular means of determining whether the infection is venereal or non-venereal becomes essential," Harper says.

The analysis of the repeat region of the ARP gene in 32 strains of pathogenic Treponema showed that the sexually transmitted strains contained multiple types of repeat motifs, while the non-venereal subspecies contained only one type of motif.

In addition, the researchers found the presence of multiple, but distinct, repeat motifs in the two types of sexually transmitted Treponema examined, suggesting that a diverse repertoire of repeat motifs has evolved at least two times in association with sexual transmission.

"The kind of changes we found in the ARP gene are consistent with rapid evolution," Harper said. "This scenario lends further support to several prominent theories about the origin of syphilis, including that the pathogen arose with the return of Columbus from the New World."


'/>"/>

Contact: Beverly Clark
beverly.clark@emory.edu
404-712-8780
Emory University
Source:Eurekalert

Related medicine news :

1. Syntermed licenses Emory imaging technology for improved evaluation of heart failure patients
2. Sleep Apnea Linked to Memory Loss
3. Memory loss linked to common sleep disorder
4. Nutrition 21 Launches Iceland Health(R) Advanced Memory Formula via Direct Response Channel
5. Smoking Tied to Memory Loss in Middle Age
6. Drinking polyphenol-rich Concord grape juice may improve memory in older adults
7. Discovery of cell linked to learning and memory
8. Memory lane: Older persons with more schooling spend fewer years with cognitive loss
9. Moral philosopher questions memory manipulation
10. When It Comes to Memory, Its All About Location
11. Common Chemotherapy Drug Linked to Memory Problems
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2017)... ... April 29, 2017 , ... TransDark is a set of dynamic transitions ... the next without having to set a single keyframe in Final Cut Pro ... video production. , TransDark features dynamic transitions that momentarily splits the RGB layers of ...
(Date:4/28/2017)... ... April 28, 2017 , ... An April 24th article on Yahoo! Beauty discusses ... with the help of a weight loss surgery. The woman, declaring “I will not hate ... been left following her dramatic weight loss. Dr. Feiz & Associates notes that, while it ...
(Date:4/28/2017)... ... 2017 , ... Beginning in 2017, Ridgecrest Herbals will be phasing out the ... ClearLungs Extra Strength formula. To ensure that the effectiveness of Clear Lungs Extra Strength ... , Removal of the homeopathic element , Adding their ...
(Date:4/28/2017)... ... April 28, 2017 , ... Ushio ... These lamps offer an instant energy-saving solution for F32T8 fluorescent lamps on most ... disconnect ballasts. These 50,000 hour rated lamps utilize the existing electronic ballast, saving ...
(Date:4/28/2017)... ... April 28, 2017 , ... From April 30 to May ... Medicine will host industry leaders for the annual spring Convention & Expo, called ... industry adapt to the issues currently affecting urgent care and on-demand healthcare. , ...
Breaking Medicine News(10 mins):
(Date:4/25/2017)... 2017 Endo International plc (NASDAQ: ENDP ) ... of its senior management team will host a conference call and ... The dial-in number to access the call is ... the passcode is 6086379. Please dial in 10 minutes prior to ... replay of the call will be available from May 9, 2017 ...
(Date:4/20/2017)... MINNEAPOLIS , April 20, 2017  Cogentix ... company focused on providing the Urology, Uro/Gyn and ... reported that Ash Keswani has joined the Company ... In this newly created position, Mr. Keswani will ... and CEO. "Our organization is delighted ...
(Date:4/20/2017)... April 20, 2017  RXi Pharmaceuticals Corporation (NASDAQ: ... that address significant unmet medical needs, today announced ... Company,s consumer product development program, based on its ... for Investigative Dermatology (SID) 76 th Annual ... promote the sciences relevant to skin health and ...
Breaking Medicine Technology: