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Emisphere Names Adam Friedman Associates IR Agency of Record

Proactive Investor Relations Program Sets Stage for Increased Visibility

Among Shareholders and Investors

CEDAR KNOLLS, N.J., Dec. 6 /PRNewswire-FirstCall/ -- Emisphere Technologies, Inc. (Nasdaq: EMIS) announced today that it has retained Adam Friedman Associates, LLC (AFA) as its agency of record for Investor Relations. Emisphere is a biopharmaceutical company that focuses on a unique and improved delivery of therapeutic molecules and pharmaceutical compounds using its eligen(R) technology.

AFA will craft general ongoing investor relations strategies for Emisphere and work to implement tactical communications, such as investor conferences, collateral materials and roadshows.

"As a 'new' Emisphere continues to emerge, it is vital that we maintain clear and strategic communications with our existing investor base and reach out to new shareholders," said Michael V. Novinski, President and Chief Executive Officer. "Securing the services of AFA will help us communicate to shareholders, investors and analysts, which we believe will help us to realize enhanced stock valuation over time."

About Emisphere Technologies, Inc.

Emisphere Technologies, Inc. is a biopharmaceutical company that focuses on a unique and improved delivery of therapeutic molecules using its eligen(R) technology. These molecules and compounds could be currently available or in development. Such molecules are usually delivered by injection; in many cases, their benefits are limited due to poor bioavailability, slow on-set of action or variable absorption. The eligen(R) technology can be applied to the oral route of administration as well other delivery pathways, such as buccal, rectal, inhalation, intra-vaginal or transdermal. The web site is:

About Adam Friedman Associates

A leading independent public relations firm headquartered in New York City, Adam Friedman Associates specializes in the strategic practice of corporate and investor relations. The agency represents companies that seek broader exposure to investors, increased analyst coverage, improved valuation, and greater recognition in the business and financial press. Additional information is available at

Safe Harbor Statement Regarding Forward-Looking Statements

The statements in this release and oral statements made by representatives of Emisphere relating to matters that are not historical facts (including without limitation those regarding future performance or financial results, the timing or potential outcomes of research collaborations or clinical trials, any market that might develop for any of Emisphere's product candidates and the sufficiency of Emisphere's cash and other capital resources) are forward-looking statements that involve risks and uncertainties, including, but not limited to, the likelihood that actual performance or results could materially differ, that future research will prove successful, the likelihood that any product in the research pipeline will receive regulatory approval in the United States or abroad, the ability of Emisphere and/or its partners to develop, manufacture and commercialize products using Emisphere's drug delivery technology, or Emisphere's ability to fund such efforts with or without partners. Emisphere undertakes no obligation to update any of these statements. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as to the date hereof. Accordingly any forward-looking statements should be read in conjunction with the additional risks and uncertainties detailed in Emisphere's filings with the Securities and Exchange Commission, including those factors discussed under the caption "Risk Factors" in Emisphere's Annual Report on Form 10-K (file no. 000-17758) filed on March 6, 2007, and our Quarterly Report on Form 10-Q for the quarter ended March 31, 2007, filed on May 7, 2007 (file no. 000-17758) and for the quarter ended June 30, 2007, filed on August 7, 2007 (file No. 000-17758).

SOURCE Emisphere Technologies, Inc.
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