Eminent scientists to lecture in Dallas(raditional health care disciplines to in...),Health

Date:3/27/2008

raditional health care disciplines to incorporate multidisciplinary perspectives, and, in the process, is reshaping approaches to disease and treatment. Yet creating a workable academic and community-based multi-institutional infrastructure to facilitate such perspectives is a great challenge. This session will present the view of the medical center in developing a modern clinical research enterprise that ensures a synergy created by cooperation and involvement across health care disciplines. A key question of such integration is: How do we effectively merge the interests and activities of those medical disciplines with long histories of high-level clinical research investigation with other health science fields, such as oral health, in which clinical research expertise and infrastructure are less-well-developed?

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Friday, April 4, 11:30 a.m.

Eric Olson
University of Texas, Southwestern Medical Center
Dallas, Texas, USA

Genetic Control of Heart Development and Disease

Heart formation involves a precisely orchestrated series of morphologic and molecular events that, if perturbed even subtly, can have catastrophic consequences. Many of the transcription factors that control heart development also regulate remodeling of the adult heart in response to injury and stress-signaling. Mechanistic dissection of the transcriptional circuits that regulate cardiac gene expression has opened opportunities for genetic and pharmacological modification of cardiac function. We have discovered several signal-responsive and cell-type-restricted transcriptional co-activators and co-repressors that control cardiac development and remodeling.

For example, the myocardin family of co-activators stimulates the activity of SRF, and CAMTA co-activates Nkx2-5, whereas Class II histone deacetylases (HDACs) function as signal-dependent repressors of MEF2. The functions of co-activators and co-repressors, as well as the involvem
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Contact: Linda Hemphill lhemphill@iadr.org 703-299-8091 International & American Association for Dental Research Source:Eurekalert

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