Navigation Links
Emerging lymphoma and myeloma treatments focus on improving individual patient response
Date:12/12/2011

onventino Center in Ballroom 20A.

The Bruton's Tyrosine Kinase (BTK) Inhibitor PCI-32765 Induces Durable Responses in Relapsed or Refractory (R/R) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL): Follow-up of a Phase Ib/II Study [Abstract 983]

A recent update of a multicenter Phase Ib/II clinical trial concludes that the novel Bruton's Tyrosine Kinase (BTK) inhibitor PCI-32765 may be an important new targeted treatment approach for patients with chronic lymphocytic leukemia (CLL).

Tyrosine kinase enzymes are important targets for cancer research because they function as "on/off switches" in many cell functions and can signal cells to either maintain normal functioning or to grow uncontrollably, leading to cancer. BTK in particular is largely responsible for the signaling that drives normal B-cell development, making it a primary target for research on B-cell malignancies such as non-Hodgkin lymphoma (NHL).

PCI-32765 is an orally-administered BTK inhibitor that induces apoptosis, or programmed cell suicide, and inhibits function of malignant B-cells. Earlier promising studies of PCI-32765 have shown that the compound may be highly active and tolerable in patients with CLL.

The current analysis summarizes results of an ongoing study using PCI-32756 as a treatment for patients with relapsed CLL. Two cohorts of CLL patients were treated with PCI-32765 at doses of either 420 mg (n=27) or 840 mg (n=34) daily for 28-day cycles until they showed signs of disease progression. Nearly three-fourths (72%) of participating patients had at least one high-risk feature, indicating that they may not respond well to treatment.

After a review of the current analysis, researchers concluded that PCI-32765 was associated with high rates of six-month progression-free survival in patients with relapsed CLL. At 10 months follow-up, 70 pe
'/>"/>

Contact: Lindsey Love
llove@hematology.org
540-538-9326
American Society of Hematology
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9

Related medicine news :

1. Emerging public health crisis linked to mortgage default and foreclosure
2. Emerging pharmaceutical platform may pose risks to retinal health
3. Georgia Tech researchers receive 3 NSF Emerging Frontiers awards
4. ASCO: Emerging trends in radiation therapy for women over 70 with early stage breast cancer
5. ATS issues report on emerging issues in HIV-associated pulmonary disease
6. Emerging drug class may enhance red blood cell production in anemic patients
7. New Society for Social Neuroscience to help guide emerging field
8. Live streaming of emerging brain science and health news
9. Emerging E. coli strain causes many antimicrobial-resistant infections in US
10. Neuxpower Selected as 2010 Emerging Technology Vendor by CRN Magazine
11. Experts explore emerging evidence linking diabetes and cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2015)... The Workgroup for Electronic Data Interchange (WEDI), the ... IT to create efficiencies in healthcare information exchange, released ... The white paper by WEDI’s ICD-10 Testing Subworkgroup provides ... by focusing on primary considerations and steps for external ... 1, 2015 implementation date. Download the white paper ...
(Date:3/2/2015)... The minimally invasive surgical instruments ... of 6.1% to reach $14,133.0 million by 2019 ... such as advantages of minimally invasive surgeries over ... minimally invasive surgeries and increasing number of surgical ... global minimally invasive surgical instruments market. , For ...
(Date:3/2/2015)... 02, 2015 Dinner preparation and ... to the success of DinnerDork , a ... and delicious for thousands of busy customers. The ... by expanding to offer a total of 6 ... seasonally appropriate classic recipes and comfort foods; Paleo ...
(Date:3/2/2015)... Regulatory Compliance Associates® Inc. (RCA), ... and technical consulting, announces Mr. Seyed Khorashahi has ... , Before joining RCA, Mr. Khorashahi had over ... all aspects of developing safety-critical medical devices. ... Regulatory Compliance Associates Inc., Baxter Healthcare, and Beckman ...
(Date:3/2/2015)... March 02, 2015 What are the ... physicians request references? When are interviews scheduled, how can ... opportunities?, Both training and practicing physicians who are looking ... questions and more at the PracticeLink Physician Career Advancement ... drop-in Job Fair is from 5:30 to 8:30 p.m. ...
Breaking Medicine News(10 mins):Health News:WEDI Releases New White Paper on ICD-10 Testing for Small Providers 2Health News:Minimally Invasive Surgical Instrument Market - Global Forecast to 2019 - New Report by MarketsandMarkets 2Health News:DinnerDork Announces New Meal Planning Support for the Home Cook 2Health News:DinnerDork Announces New Meal Planning Support for the Home Cook 3Health News:Regulatory Compliance Associates® Inc. Welcomes Seyed Khorashahi as Chief Operating Officer 2Health News:PracticeLink to Host a Career Advancement Workshop and Job Fair in Houston 2
... Study finds twice the incidence of ,food insecurity, , , TUESDAY, ... smokers are more likely to be underfed and undernourished, a ... members of smoking households, but children feel the impact the ... at New York University School of Medicine. , "We know ...
... 4 AlphaDetail, Inc. is growing.,As a leader ... to the Global Life Sciences Industry, the company ... senior staff members to its Professional,Services Group., ... based in,Alphadetail,s San Mateo, California headquarters office. Gloria ...
... Misonix, Inc.,(Nasdaq: MSON ), today announced that ... supplier of after market products, services,and test equipment ... study in Sweden at the country,s annual clinical ... was presented by the School,for Technology and Health, ...
... organs and other internal structures of the human body. ... that can predict the sound transmission of improved designs ... processing large quantities of data and can be run ... University Medical Centre and Oldelft Ultrasound are now using ...
... 2008) In the first-ever study of its kind, a ... Research Institute at Harbor-UCLA Medical Center (LA BioMed) report ... Hispanics took longer to respond to medication for depression ... English-speaking Hispanics. , Using data from the nation,s largest ...
... by nearly 100%, operating loss reduced by 44%, ... ), a leading provider of quantitative imaging for clinical,trials, ... 2008 were,over $1.8 million, a 33% increase over prior ... 30, 2008 were approximately $5.2,million compared to nearly $4.2 ...
Cached Medicine News:Health News:Smokers' Homes More Likely to House Hungry Kids 2Health News:Smokers' Homes More Likely to House Hungry Kids 3Health News:AlphaDetail, Inc. Continues Bi-coastal Expansion 2Health News:Misonix Subsidiary, Sonora Medical Systems, Announces a Major Ultrasound Probe Study 2Health News:Misonix Subsidiary, Sonora Medical Systems, Announces a Major Ultrasound Probe Study 3Health News:Misonix Subsidiary, Sonora Medical Systems, Announces a Major Ultrasound Probe Study 4Health News:Response rates to antidepressants differ among English- and Spanish-speaking Hispanics 2Health News:VirtualScopics Reports Record Third Quarter 2008 Revenue and Gross Profit 2Health News:VirtualScopics Reports Record Third Quarter 2008 Revenue and Gross Profit 3Health News:VirtualScopics Reports Record Third Quarter 2008 Revenue and Gross Profit 4Health News:VirtualScopics Reports Record Third Quarter 2008 Revenue and Gross Profit 5Health News:VirtualScopics Reports Record Third Quarter 2008 Revenue and Gross Profit 6
(Date:3/2/2015)... SAN JOSE, California , 2 marzo 2015 ... che ha aperto la strada alla fusione con ... dell,articolazione sacroiliaca (SI) con iFuse Implant System ® ... iFuse sono stati eseguiti nel mondo intero utilizzando ... tecnica chirurgica iFuse viene sempre più adottata guadagnando ...
(Date:3/2/2015)... March 2, 2015 Shire plc (LSE: ... company has submitted a New Drug Application (NDA) with the ... lifitegrast for the treatment of signs and symptoms of dry ... be the first treatment indicated to address both the signs ... which affects millions of people," said Philip J. Vickers ...
(Date:3/2/2015)... N.J. and BETHESDA, Md. ... development-stage immunotherapy company focused on treating and preventing autoimmune ... 2-stage, anti-IL-15 monoclonal antibody (AMG 714) from Amgen (NASDAQ: ... exclusive license agreement, Celimmune has the rights to develop, ... excluding Japan . Concurrently, Amgen has ...
Breaking Medicine Technology:SI-BONE, Inc. rivela l'obiettivo di 15.000 interventi con iFuse 2SI-BONE, Inc. rivela l'obiettivo di 15.000 interventi con iFuse 3SI-BONE, Inc. rivela l'obiettivo di 15.000 interventi con iFuse 4Shire Submits Application to the U.S. FDA for Approval of Lifitegrast for Treatment of Dry Eye Disease in Adults 2Shire Submits Application to the U.S. FDA for Approval of Lifitegrast for Treatment of Dry Eye Disease in Adults 3Shire Submits Application to the U.S. FDA for Approval of Lifitegrast for Treatment of Dry Eye Disease in Adults 4Celimmune Announces Anti-IL-15 Antibody Licensing and Option Agreements with Amgen 2Celimmune Announces Anti-IL-15 Antibody Licensing and Option Agreements with Amgen 3
... LYON, France, May 11, 2012 Mylan Inc. (Nasdaq: ... launched Atorvastatin Calcium Tablets, 10 mg, 20 mg, 40 ... the Netherlands and Ireland. Mylan has received marketing authorization ... its product immediately. Atorvastatin Calcium is the generic version ...
... /PRNewswire-iReach/ -- Electrochemical Oxygen Concepts (EO2™ ... chronic wound treatment device, announced it has been ... Federal Supply Schedule (FSS) contract, administered by The ... ® , a noninvasive, electrochemical low-dose tissue oxygenation ...
Cached Medicine Technology:Mylan Launches Generic Lipitor® in Five European Countries 2New Chronic Wound Treatment Device Receives Award from Veterans Healthcare Program 2New Chronic Wound Treatment Device Receives Award from Veterans Healthcare Program 3
... drapes from Cardinal Health will change the ... in your facility. , ,Shrinking budgets and ... controlled at every turn without sacrificing the ... Each decision must be evaluated from the ...
... Drape features less aggressive adhesive strip ... strip for easy removal, aggressive incise ... poly film, and product number identification. ... box of 5 or non-sterile in ...
... and near patient testing is growing 13 ... posed unique problems for hospitals and clinical ... to decentralized areas focused on patient care ... is the reality of controlling staffing costs ...
... includes genomic DNA Arrays, an ... By utilizing Vysis' patented comparative ... multi-target assessment, the GenoSensor is ... targets in a single test ...
Medicine Products: