Navigation Links
Emerging lymphoma and myeloma treatments focus on improving individual patient response
Date:12/12/2011

or rituximab every two months for up to two years.

After a complete assessment by both investigators and an independent radiology review, trial data revealed that treatment with GA101 resulted in higher response rates in patients compared to treatment with rituximab. The ORR for GA101 was 33.3 percent versus 44.6 percent for rituximab, and the complete remission (or unconfirmed complete remission) rate in the GA101 arm was 12.2 percent compared to 5.3 percent for rituximab.

Overall, GA101 was well tolerated by most study participants. Although patients on GA101 treatment had a higher rate of infusion reactions, which are a common complication of treatment with monoclonal antibodies, they were generally considered mild and did not result in significant differences in treatment discontinuation. A greater number of patients in the rituximab arm experienced severe adverse events during the four-week induction period (nine patients vs. five GA101 patients). Severe adverse events in GA101 patients included infusion reactions, neutropenia with fever, pleural effusion (a build-up of fluid in the lung tissue), and kidney stones. Finally, more rituximab-treated patients than GA101-treated patients discontinued therapy during the induction period.

"This is the first head-to-head trial of a novel anti-CD20 monoclonal antibody, GA101, against rituximab and we are encouraged to see a trend toward higher response rates without appreciable differences in safety," said lead author Laurie H. Sehn, MD, MPH, Clinical Associate Professor in the Division of Medical Oncology at the University of British Columbia and the British Columbia Cancer Agency, Center for Lymphoid Cancer in Vancouver, Canada. "Given the promising efficacy of this drug, definitive Phase III studies evaluating its benefit are warranted and are currently underway."

Dr. Sehn will present this study in an oral presentation on Monday, December 12, at 8:00 a.m. PST at the San Diego C
'/>"/>

Contact: Lindsey Love
llove@hematology.org
540-538-9326
American Society of Hematology
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9

Related medicine news :

1. Emerging public health crisis linked to mortgage default and foreclosure
2. Emerging pharmaceutical platform may pose risks to retinal health
3. Georgia Tech researchers receive 3 NSF Emerging Frontiers awards
4. ASCO: Emerging trends in radiation therapy for women over 70 with early stage breast cancer
5. ATS issues report on emerging issues in HIV-associated pulmonary disease
6. Emerging drug class may enhance red blood cell production in anemic patients
7. New Society for Social Neuroscience to help guide emerging field
8. Live streaming of emerging brain science and health news
9. Emerging E. coli strain causes many antimicrobial-resistant infections in US
10. Neuxpower Selected as 2010 Emerging Technology Vendor by CRN Magazine
11. Experts explore emerging evidence linking diabetes and cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2015)... Thermi, formerly ThermiAesthetics, a fast growing, ... into its new company headquarters in Irving, Texas. ... rapid worldwide expansion and houses the corporate departments ... employees, including those of the warehousing, shipping and ... of the fastest growing aesthetic companies in the ...
(Date:6/2/2015)... Chicago, IL (PRWEB) June 02, 2015 ... live action adaptions of comic books, comic books themselves ... tool. , Comics Uniting Nations plans to produce educational ... Nations' forthcoming Global Goals for Sustainable Development - an ... as extreme poverty, hunger, health, education, sustainable energy, inequality, ...
(Date:6/2/2015)... View, CA (PRWEB) June 02, 2015 ... mandated vaccination schedule for children to attend public or ... Judiciary and Education but bypassed the Appropriations Committee (Sacramento ... floor 25-10 despite contentious hearings. , “We believe ... Personal Belief Exemptions (PBEs) more than it will (the) ...
(Date:6/2/2015)... June 02, 2015 “We want men to ... (UV) sun rays”, states Marta Phillips, owner of SunGrubbies.com, ... sun hats and sun accessories that work well for outdoor ... immediately evident. Sometimes sun damage can take up to thirty ... are prime areas for skin cancer to occur. That ...
(Date:6/1/2015)... The National Association of Professional ... a 2015-2016 inductee into its VIP Woman of the ... for leadership in life coaching. NAPW is the nation’s ... than 700,000 members and over 200 operating Local Chapters. ... distinction,” said NAPW President Star Jones. “Her work as ...
Breaking Medicine News(10 mins):Health News:Thermi Moves to New Corporate Headquarters as Rapid Company Expansion Continues 2Health News:Can Comics Help the United Nations Save the World? 2Health News:Can Comics Help the United Nations Save the World? 3Health News:A Voice For Choice Releases A Statement As SB277 Is Referred To Single Assembly Committee And Bypasses Education and Judicial Scrutiny 2Health News:It is Time to Show Father Who Knows Best, Says SunGrubbies.com, a Leading Online Sun Protection Retailer 2Health News:National Association of Professional Women Inducts Marcy Herrmann, Therapist, Life Coach, Advanced Handwriting Analyst, Into its VIP Professional Woman of the Year Circle 2
... Newly proposed asthma outcome measures will help standardize and ... the National Institutes of Health (NIH) spends annually to ... Inc. (MCAN), the nation,s only organization focused solely on ... led to groundbreaking improvements in better understanding and managing ...
... Women become less likely to insist on condom use during ... finds. Declining condom use was most notable among women ... from poorer backgrounds. "We know unprotected sex puts women ... yet there has been a gap in research specifically focusing ...
... News) -- Women become less likely to insist on condom ... new research finds. Declining condom use was most notable ... who came from poorer backgrounds. "We know unprotected sex ... transmitted diseases, yet there has been a gap in research ...
... CHICAGO --- Maintaining a healthy lifestyle from young adulthood ... disease risk in middle age, according to a new ... adults can maintain ideal cardiovascular health factors as they ... "Many middle-aged adults develop unhealthy diets, gain weight and ...
... humans may increase the risk of dying from lung cancer, ... Journal of the National Cancer Institute. Starting in ... exposure to diesel exhaust and lung cancer. In 1989, the ... as a probable carcinogen. To determine the association ...
... have figured out how the human body keeps essential ... genetic repeats and "junk" DNA. Frdric Chdin, associate ... describes the research in a paper published today (March ... work could lead to treatments for lupus and other ...
Cached Medicine News:Health News:NIH asthma outcome measures aim to maximize research investments, reduce disparities 2Health News:NIH asthma outcome measures aim to maximize research investments, reduce disparities 3Health News:College Women's Condom Use Falls in Freshman Year 2Health News:College Women's Condom Use Falls During Freshman Year 2Health News:Heart healthy choices now pay off later 2Health News:Studies show exposure to diesel exhaust may increase lung cancer mortality 2Health News:Studies show exposure to diesel exhaust may increase lung cancer mortality 3Health News:R-loops break down gene silencing 2
(Date:6/2/2015)... June 2, 2015 ... mejora  de 7,9 meses en la supervivencia libre ... con cáncer colorrectal metastático inoperable (mCRC) tratados  en ... Y-90 más quimioterapia    Los beneficios ... directamente al hígado con la quimioterapia sistémica actual ...
(Date:6/1/2015)... , UAE, June 2, 2015 ... the first, mainstream reporting standard for Corporate Sustainability ... The next big step in CSR: The Islamic Reporting Initiative ... Launched only last month, the Islamic Reporting Initiative ... the Islamic world.  The latest members to express ...
(Date:6/1/2015)... WOODBRIDGE, ON , June 1, 2015 /PRNewswire/ ... a specialty pharmaceutical company with a focus on ... health, announced its operational highlights and financial results ...  All dollar amounts referenced herein are in Canadian ... to deliver on its business strategies despite its ...
Breaking Medicine Technology:Se presenta el estudio SIRFLOX en la reunión anual ASCO 2015 2Se presenta el estudio SIRFLOX en la reunión anual ASCO 2015 3Se presenta el estudio SIRFLOX en la reunión anual ASCO 2015 4Se presenta el estudio SIRFLOX en la reunión anual ASCO 2015 5Se presenta el estudio SIRFLOX en la reunión anual ASCO 2015 6Se presenta el estudio SIRFLOX en la reunión anual ASCO 2015 7Se presenta el estudio SIRFLOX en la reunión anual ASCO 2015 8Call for Partners: Islamic CSR 2Pivotal Therapeutics Announces First Quarter Financial Results 2Pivotal Therapeutics Announces First Quarter Financial Results 3Pivotal Therapeutics Announces First Quarter Financial Results 4Pivotal Therapeutics Announces First Quarter Financial Results 5
Microwell-EIA for the detection of Insulin Autoantibody....
... GEM Premier 3000 simplifies ... In addition to unique features ... system and comprehensive menu options, ... offers Intelligent Quality Management (iQM), ...
Flatbed Agitator....
... Helmer Platelet Agitators ... drawers with non-slip texture ... air circulation for your ... designed to be used ...
Medicine Products: