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Emerging drug class may enhance red blood cell production in anemic patients
Date:12/22/2010

drug, like a PHI, that would boost the effect, maybe you could get around the steroids' side effects," says Flygare. "That would be good."

This new approach to increasing erythropoiesis by extending the self-renewal of BFU-Esresulting in creation of more EPO-responsive cellscould lead to novel therapies for other anemias.

"There are a number of anemias that are much more prevalent than DBA and that cannot be treated with EPO, either, such as anemias from trauma, sepsis, malaria, and anemia in kidney dialysis patients," says Lodish, who is also a professor of biology and bioengineering at MIT. "Whether these treatments will work in those conditions remains to be seen."


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Contact: Nicole Giese
giese@wi.mit.edu
617-258-6851
Whitehead Institute for Biomedical Research
Source:Eurekalert

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