Navigation Links
Emerging cancer drugs may drive bone tumors
Date:2/13/2013

fic to bone, Novack and her colleagues tested long-established drugs called bisphosphonates that inhibit osteoclasts and are used to treat osteoporosis.

"We found that bisphosphonate treatment protected bone from the negative effects of these drugs," Novack says. "While bisphosphonates are common for breast cancer patients, they're not, for example, commonly given to lung cancer patients. But since IAP antagonists are now in lung cancer trials, we're saying doctors may want to consider bisphosphonate treatment for lung cancer or other cancer patients receiving these drugs. Or at least closely monitor the bone status."

IAP antagonists are now only available to patients enrolled in phase 1 or 2 clinical trials. While these kinds of trials examine the short-term safety and effectiveness of new drugs, the researchers say they may not catch bone metastasis.

"These trials do not necessarily look for long-term effects of the drugs," says Chang Yang, MD, PhD, staff scientist and the paper's first author. "If the cancer is going to metastasize to bone, it may take six months to two years to see that outcome. This may not be seen during the clinical trial."

Numerous drug companies are developing IAP antagonists intended for many kinds of cancer, but only Genentech agreed to provide Novack and her colleagues with its drug, called BV6, to evaluate in the study. Because the investigators could not obtain other proprietary IAP antagonists, they also made two other similar drug compounds and found them to have the same detrimental effects on the bone.

And to further ensure that over-stimulated osteoclasts are the only culprit in the bone metastasis associated with these new drugs, they performed studies in mice that lack the ability to dial up the production of osteoclasts. Even when given IAP antagonists, these mice were protected from osteoporosis and osteoclast activation.

Together, Novack says the studies have demonstrated
'/>"/>

Contact: Julia Evangelou Strait
straitj@wustl.edu
314-286-0141
Washington University School of Medicine
Source:Eurekalert  

0

GOOD

Page: 1 2 3

Related medicine news :

1. NIH scientists reflect on gains in emerging infectious disease awareness, research and response
2. Chicago Hat Designer Tonya Gross Selected by Online Retailer Zappos.com for 2013 Emerging Designer Program
3. Queens scientist is named Emerging Scientist 2012
4. CWRUs Maxwell J. Mehlmans book examines issues emerging in genetic engineering
5. Expanding database enables discoveries in emerging field of metabolomics
6. New Immune-Deficiency Illness Emerging in East Asia
7. CDC Warns of Another Emerging Tick-Borne Threat
8. New Treatments Emerging from Immune and Inflammatory Disease R&D Pipelines
9. Lung cancer set to overtake breast cancer as the main cause of cancer deaths among European women
10. Watch and Wait Approach Often Best for Older Patients With Kidney Cancer
11. Research from the 2013 Genitourinary Cancers Symposium highlights new insights on high-risk prostate cancer prevalence and treatment, compares benefit of surveillance and surgery for management of small kidney tumors
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Emerging cancer drugs may drive bone tumors
(Date:5/24/2013)... to the new market research report “Micro Irrigation System ... by MarketsandMarkets, global micro irrigation system market expected to ... 2010 and is expected to reach $3,414.7 million by ... to 2016. , Browse:, , 150 ... 370 pages and in-depth Table Of Content ...
(Date:5/24/2013)... 24, 2013 Just about any bodyweight training ... Whitfield, a trainer based in Dallas, GA that uses a ... one pushup that is not used enough. , “The ... the standard pushup more challenging. By keeping your hands on ... the abs are being worked much harder than a standard ...
(Date:5/24/2013)... 2013 Child safety expert and author, ... end-of-year gifts for teachers that can "show appreciation for ... Van der Zande is the founder of Kidpower, a ... whose mission is to help people create cultures ... have an incredible impact on the emotional and physical ...
(Date:5/24/2013)... (PRWEB) May 24, 2013 Patients who ... more likely to suffer from gastroesophageal reflux disease or ... reported in a study published today. , The article, ... Proximal Exposure as Measured by Hypopharyngeal Multichannel Intraluminal Impedance” ... could be of great importance to individuals who live ...
(Date:5/24/2013)... BroadConnect Telecom, the nation’s leading ... IT security solutions, present small to midsized businesses ... more than fifty percent (when compared to conventional ... Bundle Pricing. BroadConnect’s hosted Voice solutions are putting ... , Starting today, until the end of June ...
Breaking Medicine News(10 mins):Health News:Micro Irrigation System Market to Reach $3414.7 Million by 2016 at a CAGR of 17.9% - New Report by MarketsandMarkets 2Health News:Micro Irrigation System Market to Reach $3414.7 Million by 2016 at a CAGR of 17.9% - New Report by MarketsandMarkets 3Health News:Medicine Ball Pushups, a Unique Bodyweight Chest Exercise, Released in Video from BodyweightTorch.com 2Health News:Kidpower's 7 Tips For Parents To Find Meaningful End-Of-Year Gifts for Your Child’s Teacher 2Health News:Kidpower's 7 Tips For Parents To Find Meaningful End-Of-Year Gifts for Your Child’s Teacher 3Health News:Kidpower's 7 Tips For Parents To Find Meaningful End-Of-Year Gifts for Your Child’s Teacher 4Health News:West Penn Allegheny Health System Physicians Pinpoint Gastroesophageal Reflux Disease (GERD) as a Factor That May Cause Chronic Cough 2Health News:BroadConnect Is Offering New Hosted PBX Bundle Pricing for New Customers, Eliminating VoIP Adoption Barriers 2
... has come out with a warning to consumers and health care ... Teq, to infants. There is reportedly a risk of intussusception. ... months of age, in three doses as an optional vaccine to ... at times, fatal. , The reporting of 28 cases ...
... lung cancer has won $ 1 million in a lottery. Wayne ... inoperable lung cancer. ,Doctors have given him a year ... he has won this lottery. But the irony that is accompanying ... annual installments over twenty years. ,Schenk is a chain ...
... University in Chicago claim that men who have undergone ... type// of dementia. This study was published in Cognitive ... on 106 men. Out of this, 25 developed a ... undergone vasectomy. According to the chief scientist of this ...
... A new study suggests that patients who develop ... family history includes alcohol// abuse may be more ... effect of medications used to treat their condition. ... shopping, hypersexuality, binge eating and pathological gambling—have been ...
... sclerosis (MS) for 10 years and have few of the disabling ... and that their symptoms will likely not ever occur to the ... that unfortunately this may not be correct. ,After ... whose MS was benign at 10 years, according to the study. ...
... screening has increased, there are still significant disparities in ... of these disparities are by ethnicity, sex, age, education ... the third most common cancer affecting men and women ... in 2005, according to background information in the article. ...
Cached Medicine News:Health News:Compulsive Gambling Linked to Parkinson's Disease Medications 2Health News:Disparities in Colon Cancer Screening Remain Among Medicare Patients 2
(Date:5/24/2013)... LOVELAND, Colo. , May 24, 2013  Heska Corporation ... veterinary diagnostic and specialty products, announced today that Dr. ... executive officer, and Jason Napolitano , executive ... Second Annual Marcum MicroCap Conference, which is being held May ... at the Grand Hyatt Hotel. The Company,s ...
(Date:5/24/2013)... 2013 China Biologic Products, Inc. (Nasdaq: CBPO, ... plasma-based biopharmaceutical company in China , ... a public announcement issued by Shanghai RAAS Blood Products ... Shenzhen Stock Exchange, that on May 21, 2013, Ms. ... one of the shareholders of the Company, and her ...
(Date:5/24/2013)... 24, 2013  Auxilium Pharmaceuticals, Inc. (Nasdaq: ... in the Deutsche Bank Health Care Conference to be ... Mr. Adrian Adams , Chief Executive ... of the Company and its product pipeline at 12:00 ... (Logo: http://photos.prnewswire.com/prnh/20101202/MM10881LOGO ) The presentation ...
Breaking Medicine Technology:Heska Corporation To Present At The Second Annual Marcum LLP MicroCap Conference 2China Biologic Comments on the Proposed Shanghai RAAS Transaction 2China Biologic Comments on the Proposed Shanghai RAAS Transaction 3China Biologic Comments on the Proposed Shanghai RAAS Transaction 4Auxilium Pharmaceuticals, Inc. To Present At The Deutsche Bank Health Care Conference 2Auxilium Pharmaceuticals, Inc. To Present At The Deutsche Bank Health Care Conference 3Auxilium Pharmaceuticals, Inc. To Present At The Deutsche Bank Health Care Conference 4
... 2011 /PRNewswire-iReach/ -- Reagent expiry dates ... compliance concern driving Quality Control departments to employ ... Research proves to be an innovative leader by ... practices this month.  Harness RISCC increases ...
... Dec. 12, 2011 Since 1994, the Huntington Medical ... various specialties, has been providing expert medical care to ... almost every major health plan and is affiliated with ... is the group,s mission to provide a collaborative healthcare ...
Cached Medicine Technology:VerGo Integrates New Solution for Tracking Compliance Dates 2The Huntington Medical Foundation -- Pasadena's Premier Medical Group 2
... of Surgical Access ...unlike any trocar system ... system is actually four systems in one ... and clinically adaptive to all of your ... and bladed or dilating tip styles, OnePort™ ...
... Pak contains: (1) 15mm obturator, ... (1) 12mm ENDOPATH thoracic trocar ... Pak contains: (1) 15mm obturator, ... ,FPK03 Thoracic Trocar Pak contains: ...
... ENDOPATH Dilating Tip Trocar is a full-featured trocar ... a spring-loaded blade shield. The shield is designed ... internal structures from puncture or laceration once the ... integrated stability sleeve option is designed to enhance ...
Operate with confidence. Autosuture is advancing the sate of both open and minimally invasive surgery by providing surgical tools that feel right, function right, and facilitate the right outcome eve...
Medicine Products: