Navigation Links
Embryos Discarded During IVF Create Stem Cell Lines
Date:1/28/2008

Study says it's a possible source for such cell lines without the ethical issues

MONDAY, Jan. 28 (HealthDay News) -- Embryos discarded from in vitro fertilization (IVF) clinics can be used to create stem cell lines, new research suggests.

Researchers from Children's Hospital Boston said this is the first study to show it's possible to derive stem cells from poor-quality IVF embryos, which could prove to be an important source of stem cells for research. Their report is published in the Jan. 27 online edition of Nature Biology.

"We have definitely shown that those embryos that can't be used clinically are a reliable source for embryonic stem cell derivation," study author Dr. Paul Lerou, a neonatologist at the hospital and an instructor of pediatrics at Harvard Medical School, said in a prepared statement.

Each year, hundreds of thousands of poor-quality embryos are regularly discarded during the course of IVF, and these could provide an ethically acceptable source of stem cells for research.

"It's a resource that's out there that we feel should be used," Lerou said.

He and his colleagues tried to derive stem cell lines from more than 400 poor-quality embryos from the IVF clinic at Brigham and Women's Hospital. They used such a large sample to be able to calculate how readily embryos at different stages of development give rise to stem cell lines.

They found that the stage of embryo development does affect the efficiency of creating stem lines.

The team was able to derive only one stem cell line from a sample of 171 embryos discarded three days after fertilization. That one stem cell line came from an "early-arrested" embryo that had stopped dividing. This is the earliest embryo stage to yield a stem cell line, the researchers said. Most human embryonic stem cell lines are derived from embryos that have become blastocysts, which usually occurs about five days after fertilization.

The findings suggest that even early-arrested embryos (sometimes called dead embryos) may contain individual cells capable of growing and dividing, the researchers said. But the 0.6 percent success rate using early-arrested embryos is too inefficient to be practical.

It was much easier to derive stem cell lines from embryos that were slightly more developed. The success rate was 4.1 percent using embryos discarded five days after fertilization, and 8.5 percent using embryos that had reach the blastocyst stage at day five of their development.

These efficiency rates are similar to those of normal frozen embryos.

"Prior work had suggested that poor-quality embryos would only rarely yield stem cell lines, but we have shown that blastocyst-stage embryos are a robust source of stem cells," senior study author Dr. George Daley, associate director of the Stem Cell Program at the hospital and an associate professor of biological chemistry and molecular pharmacology at Harvard Medical School, said in a prepared statement.

More information

The U.S. National Institutes of Health has more about stem cells.



-- Robert Preidt



SOURCE: Children's Hospital Boston, news release, Jan. 27, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Microbiotic technology developed for microinjection of zebrafish embryos
2. Study: Brain connections strengthen during waking hours, weaken during sleep
3. Independence Blue Cross Delivers Important Reminder to Women during Cervical Cancer Awareness Month
4. Undiagnosed OSA patients have altered cardiovascular responses during exercise recovery
5. Put Safety First During Winter Fun
6. Americas Blood Centers Thanks Donors During Celebration of National Blood Donor Month
7. Lower Body Temps Increase Blood Loss During Surgery
8. National Cervical Cancer Coalition Stresses Importance of Screening and Prevention During January Cervical Health Awareness Month
9. How to Survive an Unexpected Trip to the Hospital During Christmas and New Years
10. Giving the Gift of Life During the Holidays
11. Smokers Brain Centers Activate During Nicotine Cravings
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Embryos Discarded During IVF Create Stem Cell Lines
(Date:2/12/2016)... , ... February 12, 2016 , ... According to an ... are beginning to account for a significant portion of hernia repairs throughout the United ... the Beverly Hills Hernia Center notes that this trend has not only been expected, ...
(Date:2/12/2016)... ... ... Enforcement Trends: , Back to the Future , Feb. 25, 2016 — 11:00 a.m. – ... who don’t learn from history are doomed to repeat it.” , An analysis of CDRH’s ... But that takes time. , Take a close look at the warning letters the ...
(Date:2/12/2016)... , ... February 12, 2016 , ... ... announced that nominations have closed for the ISE Southeast Awards 2016. Finalists and ... announced at the ISE® Southeast Executive Forum and Awards Gala on March 15, ...
(Date:2/12/2016)... , ... February 12, 2016 , ... AssureVest Insurance Group, ... is initiating a charity drive that will raise funds earmarked to purchase computers and ... Tayloe Elementary School. , “My school is in a low-income area and has more ...
(Date:2/12/2016)... ... 2016 , ... Donor Network West, the organ procurement organization that heals lives ... San Ramon Regional Medical Center. Under the collaboration, the first of its kind, specific ... a more certain time frame for donor families for the recovery of organs. ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... On Thursday, Feb. 11, 2016, surgeons at ... North Austin Medical Center successfully completed the first robotic ... Surgical System with Trumpf Medical,s advanced operating table, ... , M.D., colorectal surgeon at the Texas Institute for ... Motion technology, which seamlessly combines the da Vinci Xi ...
(Date:2/12/2016)... , 12 februari 2016 AAIPharma ... toonaangevende leverancier van productie en ontwikkeling op ... kondigt vandaag een uitbreiding aan van steriele ... locatie in Charleston, SC ... tot meerdere recente investeringen. http://photos.prnewswire.com/prnh/20150806/256637LOGO ...
(Date:2/11/2016)... , Feb. 11, 2016 The primary goal ... future adoption patterns on the usage of liquid biopsy. ... following: - Timeframe of liquid biopsy adoption ... cfDNA and Evs—by organization type - Sample inflow to ... blood, saliva, stool, serum, and so on. - Correlation ...
Breaking Medicine Technology: