Navigation Links
Embryonic stem cells reveal oncogene's secret growth formula
Date:4/29/2010

CAMBRIDGE, Mass. (April 29, 2010) A comprehensive new gene expression study in embryonic stem cells has uncovered a transcription control mechanism that is not only more pervasive than once thought but is also heavily regulated by the cancer-causing gene c-Myc.

In research published in the April 30th edition of Cell, a team of Whitehead Institute researchers describes a pausing step in the transcription process that serves to regulate expression of as many as 80% of the genes in mammalian cells.

Scientists have long known that DNA-binding transcription factors recruit the RNA polymerase Pol II (which prompts copying of DNA into mRNA protein codes) to promoters in order to kick off the transcription process. Now researchers in the lab of Whitehead Member Richard Young have found that additional factors recruited to the promoters serve to stop transcription in its tracks shortly after it's begun.

"It's like the engine's running, but the transmission is not engaged on that transcription apparatus," says Young, who is also a professor of biology at MIT. "You need something to engage that transmission."

It turns out that for a surprisingly large number of genes in embryonic stem cells, that "something" is the transcription factor c-Myc. This so-called pause release role for c-Myc is significant, as many of c-Myc's targets are genes in highly proliferative cells. Over-expression of c-Myc is a hallmark of a number of tumors, and it now appears that c-Myc's ability to release transcriptional pausing is linked with the hyper-proliferation that is characteristic of cancer cells.

"Our findings provide the molecular basis for loss of proliferation control in some cancers," says Peter Rahl, a postdoctoral researcher in Young's lab and first author of the Cell paper.

Armed with this new understanding of c-Myc's role in controlling proliferation genes, Young and his colleagues have embarked on a search
'/>"/>

Contact: Nicole Giese
giese@wi.mit.edu
617-258-6851
Whitehead Institute for Biomedical Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New Period of Brain ‘Plasticity' Created with Transplanted Embryonic Cells
2. NIA researchers find gene to explain mouse embryonic stem cell immortality
3. Gene Holds Key to Embryonic Stem Cell Rejuvenation
4. Biologists develop efficient genetic modification of human embryonic stem cells
5. U-M Study Reveals Surprising Lack of Genetic Diversity in the Most Widely Used Human Embryonic Stem Cell Lines
6. Leading Orthopaedic Surgeon Thomas A. Einhorn Offers Breakthrough Non-Embryonic Stem Cell Surgery to Reverse Early Necrosis of the Hip
7. Researchers attack stem cells that cause colon cancer
8. Cell study finds receptor can fight tamoxifen-resistant breast cancer cells
9. Study examines global availability of treatment involving transplantation of blood stem cells
10. Selenium Helped Cells Reboot After Exposure to Cancer-Causing Chemicals
11. Bone Stem Cells Located
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... The Incredible Bulk is a revolutionary method put ... muscle by up to 30lbs in less than 12 weeks ... Stan Stevenson, prompting an investigative review. , “Our Incredible ... diet formula that allows the body to pack on a ...
(Date:1/22/2015)... AngelWeddingDress, the premier women’s dress supplier, has ... View website of AngelWeddingDress.com to find more ... dresses online for a bridal party. AngelWeddingDress offers a ... them. Its maternity wedding dresses are specially designed for ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 A new ... of experience and person-centeredness in the long-term care environment ... action across the continuum. The paper, “The Power of ... engages perspectives and practices of the patient, resident and ...
(Date:1/22/2015)... Oceanside,CA (PRWEB) January 22, 2015 For over 20 ... the Oceanside and Vista area has treated just about ... other personal injury circumstances. And for those same twenty-plus years, ... victims of all those injuries with the best possible doctor. ...
(Date:1/22/2015)... January 22, 2015 A study ... Medicine flagship journal Medicine & Science in Sports ... exercise may help reduce gastrointestinal (GI) problems associated ... , Participants in the double-blind, placebo-controlled study took ...
Breaking Medicine News(10 mins):Health News:The Incredible Bulk: Review Examining Ben Pakulski’s Brand New Bulking Muscle Building Diet Program Released 2Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3Health News:Industry Leading Chiropractor in Oceanside Joins the Doctors on Liens Network 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 3
... decided to join hands with the University of Auckland, //New ... combination or “polypills” to prevent strokes and heart attacks. ... and two drugs to prevent hypertension. The trial will check ... and its effectiveness when consumed as one pill. ,Investments ...
... drug for multiple complaints like cholesterol, blood pressure and ... Hyderabad-based laboratory//. ,Pharmacists at Dr Reddy’s have ... a cholesterol-lowering statin, two blood-pressure medicines, and blood-thinning aspirin. ... disease and stroke by 60 per cent. It will ...
... Femcon Fe, has hit pharmacy shelves. Femcon Fe, contains ... convenient in that it offers an option for women ... them, and those who dislike swallowing pills, according to ... of Rockaway, N.J. ,This product targets young ...
... we find a combination of healthy and tasty when we dine ... of low calorie foods//. ,Mostly we don’t get an indication ... depend on the chef for this piece of information, it is ... ,There is a revolution beginning world wide as people are ...
... spraying of Agent Orange and many other herbicides at a ... are in direct contact with the spray, for instance people ... to long term health risks, due to the presence of ... a series of scientific reports, communicating potential health risks due ...
... Those breast cancer patients who are still young, and ... for the stipulated //two years, post-treatment, to plan a ... patients were advised to wait for two years before ... not mandatory. ,Angela Ives of the University ...
Cached Medicine News:Health News:A Combined Heart Pill-developed by Dr. Reddy’ 2Health News:Poly-pill – A Single Drug For Multiple Complaint 2Health News:Are You Health-Conscious or Tongue- Conscious? 2
(Date:1/22/2015)... CLEVELAND , Jan. 22, 2015  ViewRay™, a privately ... entered into an exclusive distributor agreement with ITOCHU Corporation ... radiation therapy system for the treatment of cancer in ... (me-rid-i-an) system, is the world,s first and only MRI-guided ...
(Date:1/22/2015)... OAKS, Calif. , Jan. 22, 2015  Amgen (NASDAQ: ... and full year 2014 financial results on Tuesday, Jan. 27, 2015, ... be followed by a conference call with the investment community at ... Robert A. Bradway , chairman and chief executive officer, and ...
(Date:1/22/2015)... Research and Markets ( http://www.researchandmarkets.com/research/x3hp3g/microbiology ) ... Testing/Clinical Microbiology Market by Product, Clinical Application & ... report to their offering. Clinical microbiology ... the detection of infectious diseases. The respiratory diseases ...
Breaking Medicine Technology:ITOCHU Named the Exclusive Distributor for ViewRay's MRI-Guided Radiation Therapy System in Japan 2Amgen Announces Webcast of 2014 Fourth Quarter and Full Year Financial Results 2Global Microbiology Testing/Clinical Microbiology (Instrument, Analyzer, Incubator, Kit, Microscope, Molecular Diagnostics) Market - Forecast to 2019 2Global Microbiology Testing/Clinical Microbiology (Instrument, Analyzer, Incubator, Kit, Microscope, Molecular Diagnostics) Market - Forecast to 2019 3
... Minn., Nov. 17, 2010 People who are searching ... with less potential for flushing can turn to Slo-Niacin®. ... Slo-Niacin® is a niacin supplement that has been shown ... "Slo-Niacin® features a unique patented polygel® system ...
... Sutro Biopharma today announced that the company has ... financing will support the company,s ongoing development of ... the company,s biochemical protein synthesis platform to meet ... Led by Skyline Ventures, the financing round, ...
Cached Medicine Technology:Slo-Niacin® Dietary Supplement Shown to Support 'Good' Cholesterol (HDL) 2Slo-Niacin® Dietary Supplement Shown to Support 'Good' Cholesterol (HDL) 3Slo-Niacin® Dietary Supplement Shown to Support 'Good' Cholesterol (HDL) 4Sutro Biopharma Secures $36.5 Million in Series C Financing 2
... visualization of the spine. Comfortable ... are provided for all body ... arms in both superior and ... can be positioned for a ...
High temperature loop tip cautery....
Thru cut kerrison style punch 30 deg, 2.75 X 1.4 mm cut, 110 working length....
Aaron 2250 is a multipurpose electrosurgical generator with monoploar and bi-polar functions....
Medicine Products: