Navigation Links
Embryonic stem cells reveal oncogene's secret growth formula
Date:4/29/2010

CAMBRIDGE, Mass. (April 29, 2010) A comprehensive new gene expression study in embryonic stem cells has uncovered a transcription control mechanism that is not only more pervasive than once thought but is also heavily regulated by the cancer-causing gene c-Myc.

In research published in the April 30th edition of Cell, a team of Whitehead Institute researchers describes a pausing step in the transcription process that serves to regulate expression of as many as 80% of the genes in mammalian cells.

Scientists have long known that DNA-binding transcription factors recruit the RNA polymerase Pol II (which prompts copying of DNA into mRNA protein codes) to promoters in order to kick off the transcription process. Now researchers in the lab of Whitehead Member Richard Young have found that additional factors recruited to the promoters serve to stop transcription in its tracks shortly after it's begun.

"It's like the engine's running, but the transmission is not engaged on that transcription apparatus," says Young, who is also a professor of biology at MIT. "You need something to engage that transmission."

It turns out that for a surprisingly large number of genes in embryonic stem cells, that "something" is the transcription factor c-Myc. This so-called pause release role for c-Myc is significant, as many of c-Myc's targets are genes in highly proliferative cells. Over-expression of c-Myc is a hallmark of a number of tumors, and it now appears that c-Myc's ability to release transcriptional pausing is linked with the hyper-proliferation that is characteristic of cancer cells.

"Our findings provide the molecular basis for loss of proliferation control in some cancers," says Peter Rahl, a postdoctoral researcher in Young's lab and first author of the Cell paper.

Armed with this new understanding of c-Myc's role in controlling proliferation genes, Young and his colleagues have embarked on a search
'/>"/>

Contact: Nicole Giese
giese@wi.mit.edu
617-258-6851
Whitehead Institute for Biomedical Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New Period of Brain ‘Plasticity' Created with Transplanted Embryonic Cells
2. NIA researchers find gene to explain mouse embryonic stem cell immortality
3. Gene Holds Key to Embryonic Stem Cell Rejuvenation
4. Biologists develop efficient genetic modification of human embryonic stem cells
5. U-M Study Reveals Surprising Lack of Genetic Diversity in the Most Widely Used Human Embryonic Stem Cell Lines
6. Leading Orthopaedic Surgeon Thomas A. Einhorn Offers Breakthrough Non-Embryonic Stem Cell Surgery to Reverse Early Necrosis of the Hip
7. Researchers attack stem cells that cause colon cancer
8. Cell study finds receptor can fight tamoxifen-resistant breast cancer cells
9. Study examines global availability of treatment involving transplantation of blood stem cells
10. Selenium Helped Cells Reboot After Exposure to Cancer-Causing Chemicals
11. Bone Stem Cells Located
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/12/2014)... 2014 Casinos in Australia ... competition from international and online casinos. Revenue is estimated ... five years through 2014-15. Greater per capita gambling expenditure ... services. Rises in discretionary income levels have also assisted ... non-essential items such as casino gambling services. Revenue is ...
(Date:7/12/2014)... "The second toes cross over the big toes ... shoes," said an inventor from East Hartford, Conn. This gave ... happening. , He then created a prototype of the Comfort ... and big toes from overlapping. This avoids discomfort and pain, ... easy to use, it's ideal for people with foot problems, ...
(Date:7/12/2014)... (PRWEB) July 12, 2014 Using and ... one of two inventors from Ashland, Va., decided that ... this. "This inspired us to conceive of our design," ... the patent-pending KIDNEY KOVER, which provides an inconspicuous way ... avoids embarrassment, as well as promotes comfort and peace ...
(Date:7/12/2014)... (PRWEB) July 12, 2014 For those who ... bodies can readily absorb the nutrients in food. The enzymes ... that are small enough to be absorbed by human bodies. ... a lack of enzymes in regular food is the cause ... product that was started by Michelle DelPresto, a mother of ...
(Date:7/12/2014)... Warminster, PA (PRWEB) July 12, 2014 ... Paddock covering a variety of men’s health questions. ... issues specific to men, why women live longer than ... article, Men's Health Made Simple featured on ... can get a hernia at any age. If you ...
Breaking Medicine News(10 mins):Health News:Casinos in Australia Industry Market Research Report Now Updated by IBISWorld 2Health News:Casinos in Australia Industry Market Research Report Now Updated by IBISWorld 3Health News:Casinos in Australia Industry Market Research Report Now Updated by IBISWorld 4Health News:New Super Digestive Enzyme, DZ10, Supercharges The Digestion Process 2Health News:Ivyland Medical Center’s Dr. Brad Paddock Offers Tips for Men’s Health 2
... 13 Today, executives from CoSentry, a leading ... and Alegent Health, one of the nation,s premier ... to construct and operate an enterprise class data ... provide the high availability requirements of Alegent Health,s ...
... times as many episodes as those who develop disease in ... -- People who develop multiple sclerosis before age 18 tend ... who develop the disease in adulthood, a new study says. ... of Brigham and Women,s Hospital and Massachusetts General Hospital in ...
... its broad-based,efforts to improve the lives of the most ... Lewiston, Maine, is the recipient of the,prestigious 2008 Foster ... the most esteemed community service honors in health care. ... prize is presented to a health care organization,that provides ...
... RoamAnywhere Mobility Router Recognized for Outstanding InnovationSANTA ... Inc.(TM), the company delivering innovative solutions in ... Technology Marketing Corporation,s (TMC(R)) INTERNET TELEPHONY ... Agito Networks, RoamAnywhere(TM) Mobility Router(TM) as a ...
... of California,s Free Online Tool Increases Physical ActivitySACRAMENTO, Calif., ... more physically active lifestyle is just a few clicks ... activity can reduce the risk of chronic diseases like ... than half of all American women (47.7 percent) engage ...
... of LifeMOUNTAIN VIEW, Calif., Jan. 13 Based on ... Sullivan recognizes Neotropix, Inc. with the 2009 ... Product Innovation of the Year . This award acknowledges ... Valley Virus), an oncolytic picorna virus for treating small ...
Cached Medicine News:Health News:CoSentry and Alegent Health Announce Collaboration for Construction of an Enterprise-Class Data Center 2Health News:CoSentry and Alegent Health Announce Collaboration for Construction of an Enterprise-Class Data Center 3Health News:CoSentry and Alegent Health Announce Collaboration for Construction of an Enterprise-Class Data Center 4Health News:St. Mary's Health System in Maine Receives Prestigious $100,000 Foster G. McGaw Prize for Excellence in Community Service 2Health News:St. Mary's Health System in Maine Receives Prestigious $100,000 Foster G. McGaw Prize for Excellence in Community Service 3Health News:St. Mary's Health System in Maine Receives Prestigious $100,000 Foster G. McGaw Prize for Excellence in Community Service 4Health News:St. Mary's Health System in Maine Receives Prestigious $100,000 Foster G. McGaw Prize for Excellence in Community Service 5Health News:St. Mary's Health System in Maine Receives Prestigious $100,000 Foster G. McGaw Prize for Excellence in Community Service 6Health News:Agito Networks Earns INTERNET TELEPHONY Magazine's 11th Annual Product of the Year Award 2Health News:Agito Networks Earns INTERNET TELEPHONY Magazine's 11th Annual Product of the Year Award 3Health News:Agito Networks Earns INTERNET TELEPHONY Magazine's 11th Annual Product of the Year Award 4Health News:MyFitness Planner Really Moves You 2Health News:Frost & Sullivan Recognizes Neotropix's Approach to the Treatment of Small Cell Lung Cancer and Neuroendocrine Cancers 2Health News:Frost & Sullivan Recognizes Neotropix's Approach to the Treatment of Small Cell Lung Cancer and Neuroendocrine Cancers 3Health News:Frost & Sullivan Recognizes Neotropix's Approach to the Treatment of Small Cell Lung Cancer and Neuroendocrine Cancers 4
(Date:7/10/2014)... 11, 2014  Major advances in radiation therapy ... being highlighted in a three-day Oncology Summit taking ... July, 2014.  Renowned national and international cancer experts from ... and exchange knowledge on modern technologies making treatment ... The Summit will address a ...
(Date:7/10/2014)... CARLSBAD, Calif. , July 10, 2014 /PRNewswire/ ... products and services, has launched the FreeRunner™ knee ... runners, who suffer from patella mal-tracking return to ... anatomy differently than other braces, providing support when ... move normally when they don,t. Patellofemoral ...
(Date:7/10/2014)... , July 10, 2014 Yesterday, ... Research,s (Moberg) medical device manufacturing facility. Rep. Kennedy ... advanced neurological monitors facilitate cutting-edge research in neurological ... Kennedy and mental health advocate, Garen Staglin ... dedicated to fostering fundamental changes that will radically ...
Breaking Medicine Technology:Improving quality and access to advanced cancer care in India and South Asia 2Improving quality and access to advanced cancer care in India and South Asia 3Improving quality and access to advanced cancer care in India and South Asia 4Improving quality and access to advanced cancer care in India and South Asia 5Breg Introduces Knee Brace to Help Runners with Patellofemoral Pain Syndrome 2Representative Patrick Kennedy visits Moberg's medical device facility to discuss improvement in brain injury care 2
... 8, 2011 The U.S. Food and Drug Administration today ... with signs and symptoms of dengue fever or dengue hemorrhagic ... tropics and subtropics. (Logo:   http://photos.prnewswire.com/prnh/20090824/FDALOGO ) ... by the bite of an infected Aedes mosquito. ...
... current era of health care reform has intensified ... to contain the growing cost of providing health ...   (Logo: http://photos.prnewswire.com/prnh/20100407/PH82315LOGO) ... and Western Connecticut Health Network,s Danbury Hospital (Danbury, ...
Cached Medicine Technology:FDA Permits Marketing of First Test to Help Diagnose Dengue Fever 2FDA Permits Marketing of First Test to Help Diagnose Dengue Fever 3Hospital-Physician Alignment Drives Improved Health Care and $4.6M Savings 2Hospital-Physician Alignment Drives Improved Health Care and $4.6M Savings 3Hospital-Physician Alignment Drives Improved Health Care and $4.6M Savings 4Hospital-Physician Alignment Drives Improved Health Care and $4.6M Savings 5
Medtronic Ophthalmics offers a comprehensive selection of corneal trephine,blades and handles. Handcrafted, sharp, uniform blade edges promote a,symetrical and vertical cut of all corneal layers....
Medtronic Ophthalmics offers a comprehensive selection of corneal trephine,blades and handles. Handcrafted, sharp, uniform blade edges promote a,symetrical and vertical cut of all corneal layers....
Medtronic Ophthalmics offers a comprehensive selection of corneal trephine,blades and handles. Handcrafted, sharp, uniform blade edges promote a,symetrical and vertical cut of all corneal layers....
Medtronic Ophthalmics offers a comprehensive selection of corneal trephine,blades and handles. Handcrafted, sharp, uniform blade edges promote a,symetrical and vertical cut of all corneal layers....
Medicine Products: