Navigation Links
Embryonic stem cells could help to overcome immune rejection problems
Date:4/11/2008

Tissues derived from embryonic stem (ES) cells could help to pacify the immune system and so prevent recipients from rejecting them, the UK National Stem Cell Network Science Meeting will hear today (11 April). Speaking at the conference in Edinburgh, Dr Paul Fairchild from the University of Oxford will tell delegates that although tissues derived from ES cells succumb to rejection, they have an inherent immune-privilege which, if exploited, could have far reaching implications for the treatment of conditions such as diabetes, heart attacks and Parkinsons.

The exciting potential of ES cells for use in regenerative medicine may only be realised by better understanding of how to manage the bodys immune response to them. With funding from the Medical Research Council, Dr Fairchild and Dr Nathan Robertson are investigating whether tissues derived from ES cells will be rejected in the conventional manner or whether the recipients will not recognise them as foreign.

So far, their findings suggest that, while ES cells are fully susceptible to rejection, they do display some underlying immune privilege which, with better understanding, could be harnessed to promote the activity of regulatory T-cells to suppress activation of the immune system.

Dr Paul Fairchild, explains: Our work provides hope that the immune system may be persuaded to accept tissues derived from ES cells more readily than has been the case for tissues and organs from conventional sources. It appears that ES cell-derived tissues contribute to their own acceptance by creating an environment conducive to T cell regulation, which may one day be harnessed therapeutically.

The Oxford team generated a panel of ES cell lines from strains of mice that differed from recipients by increasing levels of genetic disparity and used them as a source of tissues for transplantation. Their results show that while minor differences between the two strains provoke prompt rejection in the absence of immune suppression, ES cells do show an underlying tendency for immune privilege.

The next stage of the teams work is to explore further the molecular and cellular basis of this immune-privilege, whether it might be augmented therapeutically and whether unwanted viruses or tumours could exploit ES cell-derived tissues as a safe-haven where they can evade the normal immune response.


'/>"/>

Contact: Matt Goode
ukpo@uknscn.org
01-793-413-355
Biotechnology and Biological Sciences Research Council
Source:Eurekalert

Related medicine news :

1. Module map links embryonic stem cells and cancer stem cells
2. UCLA researchers examine human embryonic stem cell genome
3. Protein in Human Embryonic Stem Cells Controls Malignant Tumor Cells
4. Molecular alliance that sustains embryonic stem cell state
5. Embryonic Stem Cell Protein Inhibits Melanoma
6. Protein in embryonic stem cells control malignant tumor cells
7. Rutgers researchers unlock mysteries of vitamin A metabolism during embryonic development
8. A functional immune system can be derived from embryonic stem cells, preliminary study finds
9. UCLA stem cell scientists reprogram human skin cells into embryonic stem cells
10. Scientists Reprogram Human Skin Cells Into Embryonic Stem Cells
11. Embryonic Stem Cells Create Healthy Muscle in Mice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... FL (PRWEB) , ... February 22, 2017 , ... Gevir, ... from deer antler velvet, announced its products are coming soon to Amazon.com, the world’s ... and Shelley Thomson as a means to develop an effective natural treatment for Shelley’s ...
(Date:2/22/2017)... , ... February 22, 2017 , ... ... messaging services to the largest network of hospitals, health information exchanges, physicians ... Coordinator for Health Information Technology (ONC-HIT) 2015 Edition Health IT Module Certification via ...
(Date:2/22/2017)... ... February 22, 2017 , ... ... leads to fewer trips the emergency room, fewer hospital admissions, and better blood ... of Managed Care® (AJMC®) finds. The study can be found here . ...
(Date:2/22/2017)... Fla. (PRWEB) , ... February 22, 2017 , ... ... is just as effective on smaller and sometimes harder to reach ones, according ... were presented at the International Stroke Conference in Houston by Ricardo A. Hanel, ...
(Date:2/22/2017)... ... February 22, 2017 , ... ... newest advanced absorption cannabidiol (CBD) serum, “NANOCALM 300” Microemulsified Hemp Extract. This ... instant absorption from the mouth into the bloodstream. Far outpacing the ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... Feb. 22, 2017 General Report Contents ... Value & Growth Trends - Market Drivers & ... for each chapter segment - Section on recent ... report: https://www.reportbuyer.com/product/4665946/ This market ... methods: articulated arm lasers, fiber-delivered lasers and direct ...
(Date:2/22/2017)... 2017  Andre, DiMino, CEO of ADM Tronics Unlimited, ... innovative technologies and products, commented on ADMT,s third quarter ... 2017 in the Company,s quarterly report on Form 10Q ... Andre, DiMino stated "During the quarter ended December 31, ... a larger portion of our engineering efforts into the ...
(Date:2/22/2017)... Feb. 22, 2017 a condition where ... abdominal wall due to weak abdominal wall. Hernia ... hernia, incisional hernia, femoral hernia, umbilical hernia, and ... The hernia surgeries are performed using a mesh, ... help fixation devices. Among the available options, open ...
Breaking Medicine Technology: