Navigation Links
Embryonic pathway delivers stem cell traits
Date:5/15/2008

entiate into two kinds of mammary cells. And cells in the mammospheres retained their stem cell properties even after the EMT induction process was stopped.

Furthermore, when the Weinberg lab scientists isolated stem-cell-like cells from cultured human mammary epithelial cells or from mouse breast tissue, their properties were very similar to the EMT-induced cells. Working with Kornelia Polyak of Dana-Farber Cancer Institute and Harvard Medical School, Mani found that this was also true with normal and tumor cells obtained from human patients.

This for us is a very exciting discovery, not only because of its unexpectedness but because it offers a route by which one could in principle generate unlimited numbers of stem cells committed to create a specific cell type, says Weinberg, who is also a professor of biology at Massachusetts Institute of Technology. One could imagine, for example, that if one takes skin cells and induces them to undergo an EMT, they could become skin stem cells.

Importantly, the researchers also demonstrated that inducing the EMT process can produce cells with many characteristics of cancer stem cells. (Beginning in 2003, scientists in various labs have identified these self-renewing, tumor-seeding cells in a number of solid tumors.)

This finding could help to answer a key question about metastasis: When tumor cells spread into different sites, how do they multiply enough to form a dangerous new tumor"

If you take a population of human cancer cells that normally form a tumor very inefficiently and induce an EMT, their tumor-initiating abilities increase by about a hundred-fold, so that it takes about 10,000 cells rather than a million cells to form a tumor, says Wenjun Guo, co-lead author on the paper and postdoctoral researcher in the Weinberg lab. This suggests cancer stem cells are using pre-existing normal stem cell machinery to propagate their own self-renewal and therefore their tumor-initi
'/>"/>

Contact: Cristin Carr
carr@wi.mit.edu
617-324-0460
Whitehead Institute for Biomedical Research
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Embryonic Pathways Induce Stem Cell Traits
2. How embryonic stem cells develop into tissue-specific cells demonstrated
3. March of Dimes awards $250,000 prize to leaders in understanding embryonic development
4. Mouse Skin Cells Reprogrammed to Act Like Embryonic Stem Cells
5. Embryonic Stem Cells Turned Into Three Types of Heart Cells
6. Embryonic stem cells could help to overcome immune rejection problems
7. Module map links embryonic stem cells and cancer stem cells
8. UCLA researchers examine human embryonic stem cell genome
9. Protein in Human Embryonic Stem Cells Controls Malignant Tumor Cells
10. Molecular alliance that sustains embryonic stem cell state
11. Embryonic Stem Cell Protein Inhibits Melanoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... recent papers by a University of Colorado School ... develop treatments or vaccines for Dengue fever, West ... disease-causing flaviviruses. , Jeffrey S. Kieft, PhD, associate ... School of Medicine and an early career scientist ... recently published articles in the scholarly journals ...
(Date:4/17/2014)... April 17, 2014U.S. military personnel who served in ... concussive traumatic brain injury (TBI) were compared to ... other medical reasons. Differences in measures of overall ... months after injury are reported in an article ... journal from Mary Ann Liebert, Inc., publishers. The ...
(Date:4/17/2014)... 17, 2014-- Colic affects about one in five infants ... pediatric visits during the first several months after birth. ... was showing promise; however, the April 1, 2014 issue ... Valerie) reported on a study, "Probiotics and Infant Colic," ... reuteri for infant colic did not reduce ...
(Date:4/17/2014)... by researchers at UC Davis has shown that the ... in cell division, also boosts the mitochondrial activity to ... complex has been shown to perform both jobs. This ... to control cellular energy production, potentially advancing cancer care ... in the journal Developmental Cell . , "These ...
(Date:4/17/2014)... colored ribbon representing a disease. A pink ribbon is well ... one think of with lung cancer?, Although white has been ... disease, black may be the only one they think fits., ... primarily smokers between the ages of 51 to 79 years ... by these patients, the emotional toll it can have and ...
Breaking Medicine News(10 mins):Health News:CU researchers discover target for treating dengue fever 2Health News:Long-term effects of battle-related 'blast plus impact' concussive TBI in US military 2Health News:New study says probiotic use for infant colic is not effective in reducing symptoms 2Health News:Dual role: Key cell division proteins also power up mitochondria 2Health News:Unraveling the 'black ribbon' around lung cancer 2
... $25 million project to reduce throughout the beef production chain ... a major threat to public health. The U.S. Department ... grant at UNL on Monday, Jan. 23. The project ... cause more than 265,000 illnesses in the United States annually. ...
... Higher than normal levels of lead in the blood may ... renal cell carcinoma in smokers, according to medical researchers. ... kidneys from individuals without cancer, kidneys from individuals with cancer ... at Penn State College of Medicine. "But prior to this ...
... HealthDay Reporter , SUNDAY, Jan. 22 (HealthDay ... they believe are linked with breast cancer that may ... All three newly identified areas "contain interesting genes that ... said researcher Douglas Easton, a professor of genetic epidemiology ...
... Angry Men," Henry Fonda,s character sways a jury with his ... had allowed himself to fall sway to the social dynamics ... Virginia Tech Carilion Research Institute found that small-group dynamics -- ... -- can alter the expression of IQ in some susceptible ...
... yoga in a room heated to between 90 and 105 degrees ... it may not be for everyone, an expert warns. Exertion ... conditions, said Diana Zotos, a yoga instructor and physical therapist ... New York City. "If you have sensitivity to ...
... -- Monkeys vaccinated with an anthrax capsule vaccine were protected ... The anthrax capsule is a naturally occurring component of ... is the first successful use of a non-toxin vaccine to ... the most serious bioterrorism threats, according to the U.S. Army ...
Cached Medicine News:Health News:U. of Nebraska to lead $25 million project targeting E. coli threat 2Health News:U. of Nebraska to lead $25 million project targeting E. coli threat 3Health News:Lead blood levels may increase smokers' risk for kidney cancer 2Health News:Lead blood levels may increase smokers' risk for kidney cancer 3Health News:New Genetic Clues to Breast Cancer? 2Health News:New Genetic Clues to Breast Cancer? 3Health News:Group settings can diminish expressions of intelligence, especially among women 2Health News:Group settings can diminish expressions of intelligence, especially among women 3Health News:Avoid Getting Scorched by 'Hot Yoga' 2Health News:Anthrax Vaccine Shows Promise in Monkeys 2
(Date:1/15/2014)... 15, 2014  In an unprecedented effort to curb the spread of ... other transport vehicles, an advanced and portable UV germicidal lamp manufactured ... first time. In order to prevent EMS paramedics ... West Palm Beach Fire Rescue is the ...
(Date:1/15/2014)... , Jan. 15, 2014 The Cadence Fitness ... Fitness Center by the Medical Fitness Association, a non-profit ... achieve their full potential. The Cadence Fitness & Health ... western suburbs and second in the Chicagoland area. ...
(Date:1/15/2014)... Quebec , Jan. 15, 2014  Valeant Pharmaceuticals International, ... announced that the applicable waiting period under the Hart-Scott-Rodino ... the previously announced tender offer by its indirect wholly-owned ... outstanding shares of common stock of Solta Medical, Inc. ...
Breaking Medicine Technology:Superbugs No Longer Ride In Rescue Vehicles 2Cadence Fitness & Health Center Certified as Medical Fitness Facility 2Cadence Fitness & Health Center Certified as Medical Fitness Facility 3Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 2Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 3
... American Scientific Resources, Incorporated (OTCQB: ASFX) today announced ... containing results for the quarter ending March 31, ... review the entire 10-Q filing. (Logo: ... also like to direct investors to its corporate ...
... ANN ARBOR, Mich., May 24, 2011 ... long-term mechanical ventilation often require extensive additional care, ... A new study led by University ... chronic conditions who require long-term mechanical ventilation have ...
Cached Medicine Technology:American Scientific Resources, Inc. Announces Quarterly Results 2U-M Study: Children Dependent on Long-Term Mechanical Ventilation Require Longer, More Expensive Hospital Care 2U-M Study: Children Dependent on Long-Term Mechanical Ventilation Require Longer, More Expensive Hospital Care 3
For use under silicone strips E5381 610, E5381 611 and E5381 710. Indications: When higher buckle is required. Overall length: 6.1 mm....
Ungrooved permanent silicone strip. Indications: For trapdoor procedure. Overall length: 125 mm, 4.9 inches....
Used with Double Tantalum Clip (250 style) E5381 852. Overall length: 7.0 mm....
Our largest silicone tire with concave inner surface. Used in conjunction with the E5381 700 Circling Band (240 style). Indications: Massive breaks covering large areas. Outside diameter 31.7 mm....
Medicine Products: