Navigation Links
Embryonic pathway delivers stem cell traits
Date:5/15/2008

entiate into two kinds of mammary cells. And cells in the mammospheres retained their stem cell properties even after the EMT induction process was stopped.

Furthermore, when the Weinberg lab scientists isolated stem-cell-like cells from cultured human mammary epithelial cells or from mouse breast tissue, their properties were very similar to the EMT-induced cells. Working with Kornelia Polyak of Dana-Farber Cancer Institute and Harvard Medical School, Mani found that this was also true with normal and tumor cells obtained from human patients.

This for us is a very exciting discovery, not only because of its unexpectedness but because it offers a route by which one could in principle generate unlimited numbers of stem cells committed to create a specific cell type, says Weinberg, who is also a professor of biology at Massachusetts Institute of Technology. One could imagine, for example, that if one takes skin cells and induces them to undergo an EMT, they could become skin stem cells.

Importantly, the researchers also demonstrated that inducing the EMT process can produce cells with many characteristics of cancer stem cells. (Beginning in 2003, scientists in various labs have identified these self-renewing, tumor-seeding cells in a number of solid tumors.)

This finding could help to answer a key question about metastasis: When tumor cells spread into different sites, how do they multiply enough to form a dangerous new tumor"

If you take a population of human cancer cells that normally form a tumor very inefficiently and induce an EMT, their tumor-initiating abilities increase by about a hundred-fold, so that it takes about 10,000 cells rather than a million cells to form a tumor, says Wenjun Guo, co-lead author on the paper and postdoctoral researcher in the Weinberg lab. This suggests cancer stem cells are using pre-existing normal stem cell machinery to propagate their own self-renewal and therefore their tumor-initi
'/>"/>

Contact: Cristin Carr
carr@wi.mit.edu
617-324-0460
Whitehead Institute for Biomedical Research
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Embryonic Pathways Induce Stem Cell Traits
2. How embryonic stem cells develop into tissue-specific cells demonstrated
3. March of Dimes awards $250,000 prize to leaders in understanding embryonic development
4. Mouse Skin Cells Reprogrammed to Act Like Embryonic Stem Cells
5. Embryonic Stem Cells Turned Into Three Types of Heart Cells
6. Embryonic stem cells could help to overcome immune rejection problems
7. Module map links embryonic stem cells and cancer stem cells
8. UCLA researchers examine human embryonic stem cell genome
9. Protein in Human Embryonic Stem Cells Controls Malignant Tumor Cells
10. Molecular alliance that sustains embryonic stem cell state
11. Embryonic Stem Cell Protein Inhibits Melanoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/27/2014)... RBSEO Services, a well-established Internet ... service just at $99. RBSEO Services knows very ... costly search engine optimization service. So, the company ... and requirements into consideration. , The company ... not compromised with the service quality. The service ...
(Date:11/27/2014)... Ethane Web Technologies, an ISO 9001: 2008 certified Internet ... discount on PPC service. The discount will be available for ... on 1 December 2014 and remain valid until midnight of ... professional working at Ethane Web Technologies says, "This is a ... big discount would make the service quite affordable for them. ...
(Date:11/27/2014)... In addition to a new dessert ... home this holiday season and become educated about the ... relatives over the holidays may raise questions about the ... change in cognitive ability can occur with age, serious ... Recognizing the difference between normal aging and more serious ...
(Date:11/26/2014)... 2014 Healthpointe is proud to provide ... , and it will be led by a renowned ... field of Occupational Medicine and utilizes the latest medical ... delivers quality care for employers and their employees, and ... , As an Occupational Medicine physician, Dr. ...
(Date:11/26/2014)... November 27, 2014 Recently, Locks-Magnetic.com, a ... new collection of magnetic locks on the Internet. It ... lasts until December. , As a leading company ... platform for worldwide customers to buy high quality locks. ... more, it provides locks that are not only useful ...
Breaking Medicine News(10 mins):Health News:RBSEO Services Announces SEO Services at $99 Only 2Health News:Ethane Web Technologies Announces 10% Christmas Discount on PPC Service 2Health News:Alzheimer's Association Shares Tips to Navigate the Holiday Season 2Health News:Alzheimer's Association Shares Tips to Navigate the Holiday Season 3Health News:Alzheimer's Association Shares Tips to Navigate the Holiday Season 4Health News:Alzheimer's Association Shares Tips to Navigate the Holiday Season 5Health News:Healthpointe now offering Occupational Medicine in their Perris Medical Clinic 2Health News:Healthpointe now offering Occupational Medicine in their Perris Medical Clinic 3Health News:Fresh Products Launched by Famous Company Lock-Magnetic.com 2
... Springer will add the Journal of Cancer Education ... on behalf of the American Association for Cancer Education and ... a varied editorial board made up of MDs and PhDs ... worldwide. The Journal of Cancer Education presents ...
... ... leader in call tracking, performance analysis, sales and management training, announced that its non-profit ... loss in a Super Bowl Hearing Mission on Wednesday, February 3rd, from noon – ... ...
... NASHVILLE, Tenn. , Jan. 29 HCA ... quarter and fiscal year ended December 31, 2009 . ... Company,s year-end financial and accounting procedures. , (Logo: ... these uncertain economic times," said Richard M. Bracken , ...
... , DETROIT , Jan. 29 ... Ph.D., has been named the new president and chief executive ... oncologist, Dr. Bepler will begin his new position Feb. ... , In addition to his chief administrative duties, Dr. Bepler ...
... , CHICAGO , Jan. 29 ... national organizations representing dentists, physicians and veterinarians called on ... professionals from controversial new regulation intended to combat identity ... sent to FTC Chairman Jon Leibowitz by ...
... Research may advance development of facial recognition systems, study authors ... learn to recognize human faces, as long as they think ... In a series of experiments, researchers from Australia and France ... when they were rewarded with a sweet treat for doing ...
Cached Medicine News:Health News:CallSource joins Starkey Hearing Foundation to Tackle Children's Hearing Loss in Super Bowl Mission 2Health News:HCA Previews Fourth Quarter and Year-End 2009 Results 2Health News:HCA Previews Fourth Quarter and Year-End 2009 Results 3Health News:HCA Previews Fourth Quarter and Year-End 2009 Results 4Health News:HCA Previews Fourth Quarter and Year-End 2009 Results 5Health News:HCA Previews Fourth Quarter and Year-End 2009 Results 6Health News:HCA Previews Fourth Quarter and Year-End 2009 Results 7Health News:HCA Previews Fourth Quarter and Year-End 2009 Results 8Health News:Karmanos Cancer Institute in Detroit Names Gerold Bepler, M.D., Ph.D., as CEO 2Health News:Karmanos Cancer Institute in Detroit Names Gerold Bepler, M.D., Ph.D., as CEO 3Health News:Karmanos Cancer Institute in Detroit Names Gerold Bepler, M.D., Ph.D., as CEO 4Health News:Health Professionals Petition FTC For Relief From Red Flags Rule 2Health News:Health Professionals Petition FTC For Relief From Red Flags Rule 3
(Date:11/26/2014)... N.C. , Nov. 25, 2014  At the ... Antonio this October, KaVo Kerr Group was ... Technology Expo, offering attendees the opportunity to see and ... well-respected key opinion leaders deliver lectures on the latest ... Group products include the new DEXIS CariVu Caries Detection ...
(Date:11/26/2014)... 25, 2014  Medtronic,s roughly $43 billion ... widely discussed in the media for its US ... stronger leading player in one of the fastest ... healthcare market research firm said  the two companies ... diverse set of solutions spanning inpatient to home ...
(Date:11/26/2014)... 25, 2014  Unilife Corporation (NASDAQ: UNIS, ASX: UNS), ... systems, today announced that its Chairman and CEO, ... Piper Jaffray 26th Annual Healthcare Conference at the New ... December 2, 2014. The conference presentation ... listen only Webcast. To listen, please go to: ...
Breaking Medicine Technology:KaVo Kerr Group Showcased in Pride Institute Technology Expo at ADA Annual Meeting 2KaVo Kerr Group Showcased in Pride Institute Technology Expo at ADA Annual Meeting 3Medtronic - Covidien: Beyond Taxes, Deal Will Create Patient Monitoring Power, according to Kalorama Information 2Medtronic - Covidien: Beyond Taxes, Deal Will Create Patient Monitoring Power, according to Kalorama Information 3Unilife to Present at the Piper Jaffray 26th Annual Healthcare Conference on December 2nd 2
... 2011 Astellas Pharma Inc. (TSE: 4503) ... to conduct, in conjunction with executive management, a review of ... Prosidion was acquired as part of Astellas, acquisition of OSI ... two drug candidates in development for diabetes and obesity, as ...
... Calif., Jan. 10, 2011 Questcor Pharmaceuticals, Inc. ... to 2010.  The Company estimates that 353 new, paid Acthar ... and shipped during the quarter, up 66% from the year ... 2010.  1,680 vials and 6,666 vials of the company,s principal ...
Cached Medicine Technology:Astellas to Review Strategic Business Alternatives for Prosidion Subsidiary 2Astellas to Review Strategic Business Alternatives for Prosidion Subsidiary 3Questcor Pharmaceuticals Reports Strong Finish to 2010 2Questcor Pharmaceuticals Reports Strong Finish to 2010 3Questcor Pharmaceuticals Reports Strong Finish to 2010 4Questcor Pharmaceuticals Reports Strong Finish to 2010 5
... Edition, gives the Physician, the Administrator and ... MD Coder Web Edition over the internet. ... features of the Enterprise Server but leaves ... maintenance, upgrades and white glove user support ...
Preferred Health Resourses Practice Management System is called Remedy. The PDA version is Remedy for the Palm. It is a data capture program for your medical billing....
... and Management guidelines in selecting billing codes. As ... calculates the HCFA scores for each area and ... of changing different parts of the exam. ZapCode ... to create an audit trail of your exam. ...
... Manager is an electronic database ... data management of wounds and ... developed using industry expert consultants ... the most current assessment and ...
Medicine Products: