Embryonic pathway delivers stem c... (static ability of some breast cancers. ...)

Embryonic pathway delivers stem cell traits

Date:5/15/2008

static ability of some breast cancers.

Mani knew that during embryonic development, FOXC2 expression is restricted to mesoderm and mesoderm-derived cells when they are in an undifferentiated state, and its expression disappears once these cells differentiate. Similarly, his experiments showed that epithelial cells that undergo EMT express FOXC2, but that expression is lost when they revert back to an epithelial state.

In collaboration with Andrea Richardson and Jeffery Kutok, pathologists at Bostons Brigham and Womens Hospital, Mani went on to study FOXC2 expression in normal human breast tissue. It turned out that such cells were located precisely where researchers expect to find mammary epithelial stem cells.

As he pondered these findings and the earlier results about FOXC2s role in metastasis, Mani wondered: Just what were these cells generated by EMT that expressed FOXC2"

Were they simply fibroblasts, the most common cells in normal connective tissue" Or were they actually stem cells"

I asked Mai-Jing Liao, another postdoc in the Weinberg lab, to check whether the cells generated by EMT would have any stem cell properties, recalls Mani, now an assistant professor in the department of molecular pathology at the University of Texass M. D. Anderson Cancer Center in Houston. He said, You must be out of your mind, but it wont take more than half an hour to check.

Much to Liaos surprise, when he examined cells that had undergo an EMT, his tests did highlight surface proteins that are key markers for stem cells.

The researchers found that the cells that underwent the EMT process were mesenchymal-like in appearance and demonstrated stem-cell surface markers. The cells also displayed an increased ability to grow in suspension, forming structures called mammospheresanother trait of mammary stem cells. Some cells in the resulting mammospheres showed, in turn, stem cell markers, indicating they could differ
'/>"/>

Contact: Cristin Carr
carr@wi.mit.edu
617-324-0460
Whitehead Institute for Biomedical Research
Source:Eurekalert

0

GOOD

Page: 1 2 3 4
Related medicine news :

1. Embryonic Pathways Induce Stem Cell Traits
2. How embryonic stem cells develop into tissue-specific cells demonstrated
3. March of Dimes awards $250,000 prize to leaders in understanding embryonic development
4. Mouse Skin Cells Reprogrammed to Act Like Embryonic Stem Cells
5. Embryonic Stem Cells Turned Into Three Types of Heart Cells
6. Embryonic stem cells could help to overcome immune rejection problems
7. Module map links embryonic stem cells and cancer stem cells
8. UCLA researchers examine human embryonic stem cell genome
9. Protein in Human Embryonic Stem Cells Controls Malignant Tumor Cells
10. Molecular alliance that sustains embryonic stem cell state
11. Embryonic Stem Cell Protein Inhibits Melanoma

Post Your Comments:

(Date:5/21/2013)... The producers of Net Worth Business TV ... Ontario, Canada. The area is famous for its natural beauty ... It is located an hour from Toronto and is easily ... the Kawartha Hills, home to several towns, villages and hamlets ... area. Residents and visitors to this region will be able ...

(Date:5/21/2013)... (PRWEB) May 21, 2013 Five million ... For those who do, Tiffany Liashek, owner of ... advice. “Take a long look at credentials and experience. ... is huge,” she says. “A trainer can pay $69.50 ... scares me.” , Good trainers invest in themselves, A ...

(Date:5/21/2013)... Delmar, NY (PRWEB) May 21, 2013 ... announce the release of his first two barbering DVDs. ... viewers are enrolled barber school , cosmetology school ... the opportunity to learn from an experienced teacher and ... in classic barbering from the 1920’s – 1960’s time ...

(Date:5/21/2013)... 2013 Dallas-based TopMD™ Skin Care today ... testing the efficacy of their flagship product, CLn® ... study results appear in the May/June 2013 issue of ... Novel Sodium Hypochlorite Cleanser Shows Clinical Response and Excellent ... findings seen after consistent use of the product by ...

(Date:5/21/2013)... (PRWEB) May 21, 2013 Everspark Interactive, ... firms, has been growing rapidly over the past year ... was hired to spearhead interactive marketing efforts for Kids ... , Everspark started as a local effort, specializing ... guiding search traffic to a company's website. The company ...

Breaking Medicine News(10 mins):Health News:Net Worth Business TV Announces May Air Dates for Peterborough, Ontario 2 Health News:Sarasota Fitness Tips: Choosing a Safe Trainer and Gym 2 Health News:Sarasota Fitness Tips: Choosing a Safe Trainer and Gym 3 Health News:First Series of Barbering DVDs Launched by Third Generation Master Barber Greg Zorian; DVDs Teach the Art of Men's Haircutting, Clipper Cutting, Fades and More 2 Health News:First Series of Barbering DVDs Launched by Third Generation Master Barber Greg Zorian; DVDs Teach the Art of Men's Haircutting, Clipper Cutting, Fades and More 3 Health News:First Series of Barbering DVDs Launched by Third Generation Master Barber Greg Zorian; DVDs Teach the Art of Men's Haircutting, Clipper Cutting, Fades and More 4 Health News:First Series of Barbering DVDs Launched by Third Generation Master Barber Greg Zorian; DVDs Teach the Art of Men's Haircutting, Clipper Cutting, Fades and More 5 Health News:First Series of Barbering DVDs Launched by Third Generation Master Barber Greg Zorian; DVDs Teach the Art of Men's Haircutting, Clipper Cutting, Fades and More 6 Health News:Peer-Reviewed Article Shows CLn® BodyWash an Effective Solution for Children with Eczema 2 Health News:Peer-Reviewed Article Shows CLn® BodyWash an Effective Solution for Children with Eczema 3 Health News:Everspark Named Interactive Marketing Company for Kids II 2

[0] Net Worth Business TV Announces May Air Dates for Peterborough, Ontario [0] Sarasota Fitness Tips: Choosing a Safe Trainer and Gym [0] First Series of Barbering DVDs Launched by Third Generation Master Barber Greg Zorian; DVDs Teach the Art of Men's Haircutting, Clipper Cutting, Fades and More [0] Peer-Reviewed Article Shows CLn® BodyWash an Effective Solution for Children with Eczema [0] Everspark Named Interactive Marketing Company for Kids II

... CITY, Calif., Sept. 30 Genomic Health, Inc. ... Health,s Chief Operating Officer and Chief Financial Officer, will present ... City, on Tuesday, October 6 at 9:30 a.m. ET. ... the presentation, visit the Investor Relations section of Genomic Health,s ...

... October is National Breast Cancer Awareness Month and Topcor is ... , Available October 5th, "Clipa for a Cure" is a ... Topcor will donate 10% of the retail price of every ... American Cancer Society, breast cancer is the second leading cause ...

... ... that they now help physicians find jobs on Twitter by using the popular social ... providers. , ... CO (PRWEB) September 29, 2009 -- Onyx M.D., a Denver, Colorado-based physician recruiting company, ...

... ... live. Everyone, including doctors, administrators, nurses, et al, are encouraged to go online to ... ... first multi-disciplinary, online healthcare community. It is designed for everyone in the medical field ...

... The American Federation of Government Employees expresses grave concern at the ... would be rising by an average of 8.8% in 2010. ... for 60% of the enrollees in FEHBP, those covered by Blue ... by 15% for self coverage and 12% for family coverage. ...

... PARSIPPANY, N.J., Sept. 30 Thousands of bacteria lurk ... hygiene routines to help protect themselves from serious illness, ... College Center for Hygiene and Health in Home and ... products.(1) Despite growing concerns about influenza A (H1N1) on ...

Cached Medicine News:Health News:'Clipa for a Cure': New Pink Instant Handbag Hanger Benefits Breast Cancer Research 2 Health News:Onyx M.D. Now Tweet Jobs for Physician Job Opportunities by Specialty 2 Health News:Onyx M.D. Now Tweet Jobs for Physician Job Opportunities by Specialty 3 Health News:Online Healthcare Community, TogetherMD, is Live 2 Health News:Study Shows College Students Are Not Following CDC Recommendations to Help Protect Themselves from H1N1 and Other Threatening Germs 2 Health News:Study Shows College Students Are Not Following CDC Recommendations to Help Protect Themselves from H1N1 and Other Threatening Germs 3 Health News:Study Shows College Students Are Not Following CDC Recommendations to Help Protect Themselves from H1N1 and Other Threatening Germs 4 Health News:Study Shows College Students Are Not Following CDC Recommendations to Help Protect Themselves from H1N1 and Other Threatening Germs 5

Genomic Health to Present at the JMP Securities Healthcare Focus Conference 'Clipa for a Cure': New Pink Instant Handbag Hanger Benefits Breast Cancer Research Onyx M.D. Now Tweet Jobs for Physician Job Opportunities by Specialty Online Healthcare Community, TogetherMD, is Live AFGE Expresses Concern Over FEHBP Premium Increases Study Shows College Students Are Not Following CDC Recommendations to Help Protect Themselves from H1N1 and Other Threatening Germs

(Date:5/21/2013)... 2013 The North Shore-LIJ Health System is expanding ... compliance at North Shore University Hospital in ... rooms at Forest Hills (NY) ... The new pilot program strengthens patient safety by providing ... the first time in the US that remote video ...

(Date:5/21/2013)... , May 21, 2013 ... report is available in its catalogue: ... and Technologies for Optical Coherence Tomography (OCT) ... STUDY OBJECTIVES ... study is to offer synopsis of the ...

(Date:5/21/2013)... , May 21, 2013 Healthcare organizations expanding into ... Russia , India ... there are no shortcuts. This is proving particularly challenging, ... States. Companies must change the dialogue around BRIC, as ... local needs, and building regional partnerships to build a ...

[0] North Shore-LIJ Extends Use of 3rd Party Remote Video Auditing into ORs [0] Global Markets and Technologies for Optical Coherence Tomography (OCT)[0] Frost & Sullivan: BRIC is Not Delivering Promises of High Growth in Healthcare Markets

... Nine out of 10 non-diabetic patients treated with,Exforge achieved ... of 20 mmHg in,systolic blood pressure observed in patients ... Nearly 70% of those with high blood pressure not,at ... to achieve goal[2] , , ...

... WASHINGTON, May 21, 2007/PRNewswire-FirstCall/ -- Bristol-Myers,Squibb Company ... study,ETV-079, which showed that treatment with Baraclude ... at 48 weeks,-- a result that was ... and,24. These data from an open-label, randomized ...

Cached Medicine Technology:Exforge Helps Vast Majority of Patients Effectively Control Their,Blood Pressure After Failing on Other Medicines, According to New,Clinical Data 2 Exforge Helps Vast Majority of Patients Effectively Control Their,Blood Pressure After Failing on Other Medicines, According to New,Clinical Data 3 Exforge Helps Vast Majority of Patients Effectively Control Their,Blood Pressure After Failing on Other Medicines, According to New,Clinical Data 4 Exforge Helps Vast Majority of Patients Effectively Control Their,Blood Pressure After Failing on Other Medicines, According to New,Clinical Data 5 Exforge Helps Vast Majority of Patients Effectively Control Their,Blood Pressure After Failing on Other Medicines, According to New,Clinical Data 6 Exforge Helps Vast Majority of Patients Effectively Control Their,Blood Pressure After Failing on Other Medicines, According to New,Clinical Data 7 Exforge Helps Vast Majority of Patients Effectively Control Their,Blood Pressure After Failing on Other Medicines, According to New,Clinical Data 8 Baraclude (Entecavir) Treatment Demonstrated Greater Viral Load,Reduction Compared to Adefovir at 48 Weeks in Study of,Antiviral-Naive Chronic Hepatitis B E-Antigen Positive Patients 2 Baraclude (Entecavir) Treatment Demonstrated Greater Viral Load,Reduction Compared to Adefovir at 48 Weeks in Study of,Antiviral-Naive Chronic Hepatitis B E-Antigen Positive Patients 3 Baraclude (Entecavir) Treatment Demonstrated Greater Viral Load,Reduction Compared to Adefovir at 48 Weeks in Study of,Antiviral-Naive Chronic Hepatitis B E-Antigen Positive Patients 4 Baraclude (Entecavir) Treatment Demonstrated Greater Viral Load,Reduction Compared to Adefovir at 48 Weeks in Study of,Antiviral-Naive Chronic Hepatitis B E-Antigen Positive Patients 5 Baraclude (Entecavir) Treatment Demonstrated Greater Viral Load,Reduction Compared to Adefovir at 48 Weeks in Study of,Antiviral-Naive Chronic Hepatitis B E-Antigen Positive Patients 6

Exforge Helps Vast Majority of Patients Effectively Control Their,Blood Pressure After Failing on Other Medicines, According to New,Clinical Data Baraclude (Entecavir) Treatment Demonstrated Greater Viral Load,Reduction Compared to Adefovir at 48 Weeks in Study of,Antiviral-Naive Chronic Hepatitis B E-Antigen Positive Patients

Inquire...

...

VACUETTE Trace Element tubes - Ridged (safety screw cap) are designed to test trace elements such as Cu, Zn, Pb, etc....

Inquire...

Medicine Products:

MONOJECT Royal Blue Stopper (No Additive)MONOJECT Royal Blue Stopper (Powdered Additive)VACUETTE Trace Element tubes - Ridged (safety screw cap)MONOJECT Red Stopper (Silicone Coated Tube)