Navigation Links
Embryonic pathway delivers stem cell traits
Date:5/15/2008

CAMBRIDGE, Mass. (May 15, 2008) Studies of how cancer cells spread have led to a surprising discovery about the creation of cells with adult stem cell characteristics, offering potentially major implications for regenerative medicine and for cancer treatment.

Some cancer cells acquire the ability to migrate through the body by re-activating biological programs that have lain dormant since the embryo stage, as the lab of Whitehead Member Robert Weinberg has helped to demonstrate in recent years. Now scientists in the Weinberg lab have shown that both normal and cancer cells that are induced to follow one of these pathways may gain properties of adult stem cells, including the ability to self-renew.

In a paper published online by Cell on May 15, former postdoctoral researcher Sendurai Mani and his colleagues demonstrated in mice and in human cells that cells that have undergone an epithelial-to-mesenchymal (EMT) transition acquire several important characteristics of stem cells. Conversely, the researchers also showed that naturally existing normal stem cells as well as tumor-seeding cancer stem cells show characteristics of the post-EMT cells, including the acquisition of mesenchymal cell traits, which are usually associated with connective tissue cells.

Epithelial cells, which make up most of the human body, bind together in sheet-like structures. In embryonic development, the EMT process breaks up cell-cell adhesion in the epithelial layer, and converts epithelial cells into more loosely associated mesenchymal cells. In the context of cancer development, some cancer cells within a primary cancer may undergo an EMT, migrate through the body to their end destination, and there resume their epithelial form through a reverse process (the mesenchymal-to-epithelial transition).

Mani and his colleagues have identified FOXC2, one of the key genes involved in invasion and metastasis. In addition, FOXC2 appears to program the meta
'/>"/>

Contact: Cristin Carr
carr@wi.mit.edu
617-324-0460
Whitehead Institute for Biomedical Research
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Embryonic Pathways Induce Stem Cell Traits
2. How embryonic stem cells develop into tissue-specific cells demonstrated
3. March of Dimes awards $250,000 prize to leaders in understanding embryonic development
4. Mouse Skin Cells Reprogrammed to Act Like Embryonic Stem Cells
5. Embryonic Stem Cells Turned Into Three Types of Heart Cells
6. Embryonic stem cells could help to overcome immune rejection problems
7. Module map links embryonic stem cells and cancer stem cells
8. UCLA researchers examine human embryonic stem cell genome
9. Protein in Human Embryonic Stem Cells Controls Malignant Tumor Cells
10. Molecular alliance that sustains embryonic stem cell state
11. Embryonic Stem Cell Protein Inhibits Melanoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... (PRWEB) December 24, 2014 Risperdal lawsuit ... a mass tort litigation currently underway in Pennsylvania’s Philadelphia ... As of December 24, 2014, court documents indicate that ... behalf of individuals who developed gynecomastia (male breast growth) ... from the Court indicates that this represents an increase ...
(Date:12/24/2014)... Dallas, TX (PRWEB) December 24, 2014 ... has announced the expansion of his practice and med-spa ... to the practice’s growing list of cosmetic treatments and ... a solution into the skin,” says Dr. Ho. “As ... aging changes such as wrinkles, sun spots, discolorations or ...
(Date:12/24/2014)... Today, UWDress.com, the famous women’s dress supplier, has ... launched a site-wide wedding gown promotion. , For ... a more unexpected way, the collection should be a great ... global market, and they are available with custom service. , ... discounted prices, up to 75% off; most of them come ...
(Date:12/24/2014)... The report “Stivarga (Colorectal Cancer) – ... current treatment landscape, unmet needs, current pipeline and commercial ... drug which is used in the treatment of colon ... is also prescribed to patients who suffer from advanced ... is a multi-kinase inhibitor and it blocks many enzymes ...
(Date:12/24/2014)... BambooIndustry.com a famous bamboo flooring company ... the company announces its multiple layer bamboo panel ... these new products. , Bamboo panel is the product ... layer bamboo panel board features high quality selective bamboo ... free. The bamboo panel consists of multiple layers of ...
Breaking Medicine News(10 mins):Health News:Risperdal Lawsuits Continue to Climb, as Claims in Pennsylvania Litigation Exceed 1,180 Filings, Bernstein Liebhard LLP Reports 2Health News:Risperdal Lawsuits Continue to Climb, as Claims in Pennsylvania Litigation Exceed 1,180 Filings, Bernstein Liebhard LLP Reports 3Health News:Risperdal Lawsuits Continue to Climb, as Claims in Pennsylvania Litigation Exceed 1,180 Filings, Bernstein Liebhard LLP Reports 4Health News:Dr. Vu Ho Expands Facial Plastic Surgery Practice to Include New Skin Care Treatment 2Health News:Buy Cheap Long Sleeve Wedding Gowns At UWDress.com 2Health News:Stivarga Colorectal Cancer Treatment Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 2Health News:Stivarga Colorectal Cancer Treatment Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 3Health News:Bamboo Flooring Company Bambooindustry.com Introduces Its Multiple Layer Bamboo Panel Board Collection 2
... repertoire of full-service ophthalmological care, Global Laser Vision now offers an ... Lasik surgery. , ... (Vocus) November 13, 2008 -- ... now offers an eyeglass dispensary and contact lens for its clients ...
... Companies, Use Patient Smart Cards - CEO of Jackson Healthcare Proposes ... ... Alpharetta, GA (PRWEB) November 13, 2008 -- Frequent headlines ... for major overhaul of healthcare delivery in the United States. ...
... Under fire from thousands of members, SEIU officials ... ANGELES, Nov. 12 Caregivers who work in,California ... Los Angeles and Oakland offices of their national ... protesters are members of United Healthcare Workers-West (UHW), ...
... - Diabetes Activists Worldwide Organize Events to Draw ... Children and Adolescents, November 14 is the most ... people with diabetes worldwide. World Diabetes Day draws attention,to ... to improve care,prevent the disease in those at risk ...
... Nov. 12 Miami clinic owner Nayda,Freire, 61, ... for defrauding the,Medicare program in connection with a ... General Matthew Friedrich of the Criminal,Division and U.S. ... of,Florida announced., In addition to the prison ...
... Council for Quality,Respiratory Care (CQRC) today commended Senate ... and creative approaches to,ensuring that all Americans have ... importance of prioritizing initiatives that will identify,and eliminate ... CQRC also warned,that deep cuts in Medicare funding ...
Cached Medicine News:Health News:Eyeglass Dispensary and Contact Lens Now Available at Global Laser Vision 2Health News:Eyeglass Dispensary and Contact Lens Now Available at Global Laser Vision 3Health News:A Bold Approach to Healthcare Reform: Eliminate Insurance Companies 2Health News:A Bold Approach to Healthcare Reform: Eliminate Insurance Companies 3Health News:A Bold Approach to Healthcare Reform: Eliminate Insurance Companies 4Health News:Healthcare Workers Picket Their National Union to Protect Their Voice for Patients 2Health News:Millions Mark World Diabetes Day 2Health News:Millions Mark World Diabetes Day 3Health News:Millions Mark World Diabetes Day 4Health News:Miami Clinic Owner Sentenced to 30 Months in Prison for $10.9 Million Medicare Fraud 2Health News:Home Oxygen Leaders Commend Sen. Baucus' Efforts to Expand Health Care Access, Warn That Deep Cuts in Oxygen Benefit May Undercut Access 2
(Date:12/22/2014)... , Dec. 22, 2014  CytoSorbents Corporation (OTCQB:CTSOD), ... CytoSorb® blood purification technology to help fight deadly ... 28 countries worldwide, today announced the appointment of ... FACS, as its Senior Vice President of Clinical ... Dr. Di Russo is an accomplished ...
(Date:12/22/2014)... 22, 2014 Apnea Sciences ( www.apneasciences.com ) ... Aliso Viejo , California.  Jimmy ... tremendous growth and worldwide expansion, a new facility with ... the anti snore cure have exceeded our expectations and ... are now in 23 countries and will be increasing ...
(Date:12/22/2014)... 2014   TRU-D SmartUVC LLC, producers of ... announced today that the General Services Administration has awarded ...   This newly formed agreement will allow ... government purchasers, including Department of Veteran Affairs and Department ... contacts purchasing solutions for the Ebola effort in ...
Breaking Medicine Technology:CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 2CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 3CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 4CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 5TRU-D SmartUVC LLC Awarded General Services Administration Contract to Expand Government Customer Base 2
... Luminex Corporation (NASDAQ: LMNX ), today announced ... annual European multiplexing technology symposium, September 28-29, 2011, at ... scientific sessions, workshops, discussion groups, exhibitions and networking events ... are performing groundbreaking work in clinical diagnostics and life ...
... 26, 2011 Calgary Scientific Inc. has received ... Drug Administration (FDA) to market its industry-leading medical ... application, in the US.  With this secure, highly ... rapidly access, view, and interact with patient images ...
Cached Medicine Technology:Luminex Corporation Hosts Ninth Annual Planet xMAP Europe in Vienna 2Luminex Corporation Hosts Ninth Annual Planet xMAP Europe in Vienna 3Luminex Corporation Hosts Ninth Annual Planet xMAP Europe in Vienna 4Calgary Scientific's ResolutionMD™ Mobile Receives FDA Clearance for Diagnostic Image Viewing on iPhones® and iPads® 2Calgary Scientific's ResolutionMD™ Mobile Receives FDA Clearance for Diagnostic Image Viewing on iPhones® and iPads® 3Calgary Scientific's ResolutionMD™ Mobile Receives FDA Clearance for Diagnostic Image Viewing on iPhones® and iPads® 4
... Efficiency, versatility, and environmental ... the Optima LE-80 K Ultracentrifuge ... Coulters innovative Optima centrifugation technology, ... to cost effectively provide advanced ...
... L-XP ultracentrifuge is designed to play ... process if research involves proteomics, cytomics ... on-board computer, enhanced firmware, powerful Optima ... screen, Optima L-XP delivers superior functionality, ...
... Ultracentrifuge power for small-volume samples. With ... method of removing chylomicrons (fat particles in ... results for lipemic clarification. Lipemic samples can ... need for sendouts. The easy-to-operate tabletop ...
The Dimension RxL Max is an integrated chemistry system and is the most powerful and technologically advanced Dimension analyze with new standard for excellence in clinical diagnostics. Simply put, t...
Medicine Products: