Navigation Links
Embryonic Stem Cells Turned Into Three Types of Heart Cells
Date:4/23/2008

When transplanted into mice, they improved heart function, researchers report

WEDNESDAY, April 23 (HealthDay News) -- A multinational team of researchers has succeeded in turning human embryonic stem cells into three types of human heart muscle cells.

When transplanted, the cells also improved heart function in mice.

The findings have a number of implications, the most immediate of which would be to use the cells to test drugs.

"We have now a supply of human heart cells for biotech and drug companies to start testing the beneficial effects of drugs or the toxic effects of drugs," said Gordon Keller, senior author of a paper published in this week's issue of Nature. "There are really no roadblocks in beginning to set up such tests."

Researchers may also be able to use the cells to make artificial heart tissue, which could then be transplanted into an actual human heart.

"It's not clear how effective injecting cells directly into the heart ever will be," said Keller, who is director of the McEwen Centre for Regenerative Medicine at University Health Network in Toronto. "A huge advantage we have is that these unique progenitor cells can make three of the major types of cells in the heart, so we hope we can simply seed these progenitor cells onto scaffolding and make what might be an artificial piece of heart tissue and possibly transplanting such small pieces of tissue, and engrafting them into the heart, would be more effective than transplanting the cells themselves."

Keller's lab had previously succeeded in coaxing cardiac cells out of mouse embryonic cells.

For this study, the team used similar principles, applying specific growth factors at different stages of development, but in human embryonic stem cells.

"They're showing that different 'recipes' can induce different types of cardiac cells," said Paul Sanberg, director of the Center for Aging and Brain Repair at the University of South Florida College of Medicine in Tampa.

In this way, the researchers were able to isolate heart progenitor cells then coax them into three different types of heart cells, called cardiomyocytes, which make up functioning heart muscle.

"Now we have our hands on a cell that doesn't have the same developmental potential as embryonic stem cells but can still make three of the major types of heart cells," Keller explained. "When we have these cells in isolation, we have a better handle on directing their pathway to cells that beat, or other [cardiac] cells. That's much more difficult when we haven't isolated the cells."

Also, when these cells were transplanted, they didn't form tumors, which often happens when a group of cells is more mixed. "In essence, we have isolated the most immature human heart cells, and we think we can control these cells much better than we would if we were starting with embryonic stem cells," Keller said.

The findings will help researchers better understand how the heart develops in humans, but therapeutic applications are still a ways off.

"It's important that we understand the basic biology," Sanberg said. "But it's still going to be a while till we see this in the clinic."

More information

The National Institutes of Health has more on stem cells.



SOURCES: Gordon Keller, Ph.D., director, McEwen Centre for Regenerative Medicine, University Health Network, Toronto; Paul R. Sanberg, Ph.D., director, Center for Aging and Brain Repair, University of South Florida College of Medicine, Tampa; April 24, 2008, Nature


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Embryonic Stem Cells Repair Human Heart
2. Embryonic Human Stem Cells May Help Repair Heart Muscle, Lab Study Shows
3. Embryonic stem cells used to grow cartilage
4. Embryonic stem cells thrive when shaken
5. Stem cells in adult testes provide alternative to embryonic stem cells for organ regeneration
6. Study Probes Difference Between Embryonic, Adult Stem Cells
7. Serum carcinoembryonic antigen level can reflect adrenal adenoma
8. UC Davis researchers find evidence of mature heart cell potential in embryonic stem cells
9. Human embryonic stem cell lines created that avoid immune rejection
10. Embryonic Stem Cells Create Healthy Muscle in Mice
11. Scientists Reprogram Human Skin Cells Into Embryonic Stem Cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Embryonic Stem Cells Turned Into Three Types of Heart Cells
(Date:2/18/2017)... ... 2017 , ... A new directory from the Senior Veterans ... connect elderly veterans of America's armed forces to a range of senior care ... on this year's increase in the Veterans Pension with Aid & Attendance for ...
(Date:2/17/2017)... , ... February 17, 2017 , ... ... not kept pace. Enovate Medical has introduced an innovative workstation designed to reduce ... supporting nurses, the Encore Mobile EHR Workstation offers a lightweight, highly mobile, multi-functional ...
(Date:2/17/2017)... ... 2017 , ... Wells Pharmacy Network offers physicians WellsPx3, a ... non-controlled substances plus the ability to manage orders on their desktop or mobile ... electronic prescriptions, according to the Office of the National Coordinator of Health IT, ...
(Date:2/17/2017)... ... February 17, 2017 , ... ... **An FDAnews Webinar**, Feb. 22, 2017 — 1:30 p.m. – 2:30 p.m. ... manufacturers should be asking before selecting an FDA approval pathway? , How ...
(Date:2/17/2017)... Falls Church, VA (PRWEB) , ... February 17, ... ... Devices, Implementing the Steps to Prevent a Warning Letter, **An FDAnews Webinar**, Feb. ... , Do manufacturers distinguish between corrective action (CA) and preventive action ...
Breaking Medicine News(10 mins):
(Date:2/18/2017)... Research and Markets has announced the addition of the "Contraceptives - ... ... the US, Canada , Japan , ... Latin America , and Rest of World. Annual estimates and forecasts ... analysis is provided for these markets. Market data and analytics are derived ...
(Date:2/17/2017)... 2017  Ethicon, Inc. today announced a definitive ... held medical device company that manufactures and markets ... novel minimally invasive device for the surgical treatment ... enable Ethicon to offer patients a safe and ... surgical procedure. 1 This LINX ...
(Date:2/17/2017)... Theravance Biopharma, Inc. (NASDAQ: ... announced the presentation of positive clinical data for ... kinase (JAK) inhibitor designed to be intestinally restricted, ... European Crohn,s and Colitis Organization (ECCO). In a ... its completed Phase 1 study of single-ascending and ...
Breaking Medicine Technology: