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Embryonic Pathways Induce Stem Cell Traits
Date:5/15/2008

vered. This finding could help solve why tumor cells spread into different sites and multiply enough to form a new tumor.

"If you take a population of human cancer cells that normally form a tumor very inefficiently and induce an EMT, their tumor-initiating abilities increase by about a hundredfold, so that it takes about 10,000 cells, rather than a million cells, to form a tumor," co-lead author Wenjun Guo, a postdoctoral researcher in Weinberg's lab, said in a prepared statement. "This suggests cancer stem cells are using preexisting normal stem cell machinery to propagate their own self-renewal and therefore their tumor-initiating ability."

More information

The National Institutes of Health has more about stem cells.



-- Kevin McKeever



SOURCE: Massachusetts Institute of Technology, news release, May 15, 2008


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