Navigation Links
Embryonic Pathways Induce Stem Cell Traits
Date:5/15/2008

Regenerative ability holds promise for development of target-specific cancer drugs

THURSDAY, May 15 (HealthDay News) -- Scientists have found that normal cells and cancer cells that acquire the ability to use long dormant pathways to migrate through the body may gain properties of adult stem cells, including the ability to self-renew.

The finding helps researchers better understand adult stem cell creation -- knowledge they hope will lead to developing healthy stem cells for regenerative medicine and target-specific cancer drugs.

Research published online May 15 in Cell shows that cells that undergo an "epithelial-to-mesenchymal" (EMT) transition, in mice or humans, acquire many important stem cell characteristics. The study also shows that normal, naturally existing stem cells and tumor-seeding cancer stem cells share characteristics with these post-EMT cells.

"This for us is a very exciting discovery, not only because of its unexpectedness, but because it offers a route by which one could in principle generate unlimited numbers of stem cells committed to create a specific cell type," researcher Robert Weinberg, a professor of biology at Massachusetts Institute of Technology, said in a prepared statement. "One could imagine, for example, that if one takes skin cells and induces them to undergo an EMT, they could become skin stem cells."

Epithelial cells, which make up most of the human body, bind in sheet-like structures. In embryonic development, the EMT process disrupts this adhesion and changes the cells into more loosely associated mesenchymal cells. In the context of cancer development, some cancer cells within a primary cancer may undergo EMT, migrate through the body to their end destination, and then undergo a reverse conversion back to their original epithelial form.

Inducing the EMT process can produce cells with many characteristics of cancer stem cells, the researchers disco
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. Embryonic Stem Cells Repair Human Heart
2. Embryonic Human Stem Cells May Help Repair Heart Muscle, Lab Study Shows
3. Embryonic stem cells used to grow cartilage
4. Embryonic stem cells thrive when shaken
5. Stem cells in adult testes provide alternative to embryonic stem cells for organ regeneration
6. Study Probes Difference Between Embryonic, Adult Stem Cells
7. Serum carcinoembryonic antigen level can reflect adrenal adenoma
8. UC Davis researchers find evidence of mature heart cell potential in embryonic stem cells
9. Human embryonic stem cell lines created that avoid immune rejection
10. Embryonic Stem Cells Create Healthy Muscle in Mice
11. Scientists Reprogram Human Skin Cells Into Embryonic Stem Cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 2015 A new white paper by ... person-centeredness in the long-term care environment as well as ... continuum. The paper, “The Power of Person-Centeredness in Long-Term ... practices of the patient, resident and family experience in ...
(Date:1/22/2015)... For over 20 years, Dr. David Cruz of ... area has treated just about every type of injury that can ... for those same twenty-plus years, the team at Doctors on ... the best possible doctor. With the combined breadth of ...
(Date:1/22/2015)... A study recently published in ... Medicine & Science in Sports & Exercise shows ... reduce gastrointestinal (GI) problems associated with physical strain ... the double-blind, placebo-controlled study took 10 grams of ...
(Date:1/22/2015)... 22, 2015 IsoComforter, Inc. has introduced the ... patented IsoTube design to treat specific body parts and muscle ... progressive and easy to use patented cold therapy machine with ... related orthopedic and muscle injuries. IsoComforter has become the ...
(Date:1/22/2015)... Mass. (PRWEB) January 22, 2015 EBSCO ... (AMA) are expanding their relationship in an effort to ... around the world. While EBSCO has long made AMA journals ... a sales agent for The JAMA Network. , ...
Breaking Medicine News(10 mins):Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3Health News:Industry Leading Chiropractor in Oceanside Joins the Doctors on Liens Network 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 3Health News:IsoComforter Introduces Best of Class Cold Therapy Product to the Worldwide Market 2Health News:EBSCO Expands Partnership with the American Medical Association 2Health News:EBSCO Expands Partnership with the American Medical Association 3Health News:EBSCO Expands Partnership with the American Medical Association 4
... LANSING, Mich., March 27 Accident Fund Insurance,Company ... its,outstanding achievements in creating a safe work environment. ... experiencing one lost-time,incident, when in 2006 the Michigan ... employees unable to work. Clark Construction,received the Gold ...
... Support Health Plans Next Generation of Care Management ... and Special Need Populations, SAN ANTONIO and AUBURN, ... only locally owned and operated,non-profit HMO, announced today that ... to support its next,generation of care management programs sponsored ...
... By Tobacco Advertising and Find It,Easy to Buy Cigarettes, ... against tobacco on April 2 as they join thousands ... Day, sponsored by the,Campaign for Tobacco-Free Kids. Hundreds of ... local events, go to http://www.kickbuttsday.org/events )., This ...
... Tobacco Advertising and Find It,Easy to Buy Cigarettes, ... tobacco on April 2 as they join thousands of ... sponsored by the,Campaign for Tobacco-Free Kids. Hundreds of events ... events, go to, http://www.kickbuttsday.org/events )., This year, Kick ...
... Proposed Bush FY 2009 Budget Slashes Nursing Home ... Medicare Cuts Place Greater,Pressure on State Medicaid Program ... National and state,front line caregivers voiced opposition ... care for Michigan seniors contained in the,Bush Administration,s ...
... properties of bitter melon, a vegetable and traditional Chinese ... 2 diabetes. , Teams from the Garvan Institute of ... pulped roughly a tonne of fresh bitter melon and ... all appear to activate the enzyme AMPK, a protein ...
Cached Medicine News:Health News:Accident Fund Recognizes Clark Construction Co. for 2 Million Hours without a Lost-Time Injury 2Health News:Community First Health Plans Selects TCS Healthcare Technologies' Care Management Software System 2Health News:Community First Health Plans Selects TCS Healthcare Technologies' Care Management Software System 3Health News:California Kids 'Kick Butts' on April 2 2Health News:California Kids 'Kick Butts' on April 2 3Health News:Georgia Kids 'Kick Butts' on April 2 2Health News:Georgia Kids 'Kick Butts' on April 2 3Health News:National, State Front Line Caregivers Warn About $64 Million Cut to Medicare Funding for Care of Michigan Seniors 2Health News:National, State Front Line Caregivers Warn About $64 Million Cut to Medicare Funding for Care of Michigan Seniors 3Health News:National, State Front Line Caregivers Warn About $64 Million Cut to Medicare Funding for Care of Michigan Seniors 4Health News:A ton of bitter melon produces sweet results for diabetes 2
(Date:1/23/2015)... 2015 /PRNewswire/-- Harwood Feffer LLP ( www.hfesq.com ) is investigating ... Inc. ("Advaxis" or the "Company") (NASDAQ: ADXS ... duties to shareholders. On January 21, 2015, ... that Advaxis had misrepresented the clinical data for its ...
(Date:1/23/2015)... , Jan. 23, 2015  iMD Companies, Inc. (ICBU) has repositioned ... market share and grab a foothold in the hydroponic, hemp ... capabilities and a presence in the sector, and recently partnering ... growth of hemp and medical marijuana, iMD is committing to ...
(Date:1/23/2015)... 2015  CytoSorbents Corporation (NASDAQ CM: CTSO), a critical ... adsorber to reduce deadly inflammation in critically-ill and ... net of transaction costs, in non-dilutive funding as ... Certificate Transfer Program sponsored by the New Jersey ...
Breaking Medicine Technology:Harwood Feffer LLP Announces Investigation of Advaxis, Inc. 2iMD Companies Poised to Make Impact in Multi-Billion Dollar Medical Marijuana Sector With Recent Investments and Strategic Partnerships 2CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 2CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 3
... Jan. 26, 2012 Masimo (NASDAQ: MASI ... year financial results for the period ended December 31, 2011, after ... review the results will begin at 1:30 p.m. PT (4:30 p.m. ... Executive Officer, and Mark P. de Raad, Executive Vice President and ...
... Dr. Ira J. Haimowitz, Executive Vice President, Group Director, Intelligence ... at the eMarketing University for Brand Managers, a symposium at ... 2012. The symposium is a full-day course designed ... tactics into their marketing mix. Dr. Haimowitz will be presenting ...
Cached Medicine Technology:Masimo to Report Fourth Quarter and Full Year 2011 Financial Results After Market Close on February 14, 2012 2Masimo to Report Fourth Quarter and Full Year 2011 Financial Results After Market Close on February 14, 2012 3Ira Haimowitz, PhD, EVP, at The CementBloc, to Present on Best Practices in iPad Interactive Selling at 11th Annual ePharma Summit™ 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: