Navigation Links
Embryonic Pathways Induce Stem Cell Traits
Date:5/15/2008

Regenerative ability holds promise for development of target-specific cancer drugs

THURSDAY, May 15 (HealthDay News) -- Scientists have found that normal cells and cancer cells that acquire the ability to use long dormant pathways to migrate through the body may gain properties of adult stem cells, including the ability to self-renew.

The finding helps researchers better understand adult stem cell creation -- knowledge they hope will lead to developing healthy stem cells for regenerative medicine and target-specific cancer drugs.

Research published online May 15 in Cell shows that cells that undergo an "epithelial-to-mesenchymal" (EMT) transition, in mice or humans, acquire many important stem cell characteristics. The study also shows that normal, naturally existing stem cells and tumor-seeding cancer stem cells share characteristics with these post-EMT cells.

"This for us is a very exciting discovery, not only because of its unexpectedness, but because it offers a route by which one could in principle generate unlimited numbers of stem cells committed to create a specific cell type," researcher Robert Weinberg, a professor of biology at Massachusetts Institute of Technology, said in a prepared statement. "One could imagine, for example, that if one takes skin cells and induces them to undergo an EMT, they could become skin stem cells."

Epithelial cells, which make up most of the human body, bind in sheet-like structures. In embryonic development, the EMT process disrupts this adhesion and changes the cells into more loosely associated mesenchymal cells. In the context of cancer development, some cancer cells within a primary cancer may undergo EMT, migrate through the body to their end destination, and then undergo a reverse conversion back to their original epithelial form.

Inducing the EMT process can produce cells with many characteristics of cancer stem cells, the researchers discovered. This finding could help solve why tumor cells spread into different sites and multiply enough to form a new tumor.

"If you take a population of human cancer cells that normally form a tumor very inefficiently and induce an EMT, their tumor-initiating abilities increase by about a hundredfold, so that it takes about 10,000 cells, rather than a million cells, to form a tumor," co-lead author Wenjun Guo, a postdoctoral researcher in Weinberg's lab, said in a prepared statement. "This suggests cancer stem cells are using preexisting normal stem cell machinery to propagate their own self-renewal and therefore their tumor-initiating ability."

More information

The National Institutes of Health has more about stem cells.



-- Kevin McKeever



SOURCE: Massachusetts Institute of Technology, news release, May 15, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Embryonic Stem Cells Repair Human Heart
2. Embryonic Human Stem Cells May Help Repair Heart Muscle, Lab Study Shows
3. Embryonic stem cells used to grow cartilage
4. Embryonic stem cells thrive when shaken
5. Stem cells in adult testes provide alternative to embryonic stem cells for organ regeneration
6. Study Probes Difference Between Embryonic, Adult Stem Cells
7. Serum carcinoembryonic antigen level can reflect adrenal adenoma
8. UC Davis researchers find evidence of mature heart cell potential in embryonic stem cells
9. Human embryonic stem cell lines created that avoid immune rejection
10. Embryonic Stem Cells Create Healthy Muscle in Mice
11. Scientists Reprogram Human Skin Cells Into Embryonic Stem Cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... (PRWEB) , ... February 10, 2016 , ... ... and Video Remote Interpreting (VRI) within Healthcare, recently partnered with Heart City ... interpreting (VRI). , For nearly 23 years, Heart City Health Center has provided ...
(Date:2/10/2016)... ... February 10, 2016 , ... Compliancy Group ... associations of medical professionals throughout the country. The Guard was specifically designed to ... and procedures, employee training, regulatory updates, and compliance coaching. , In addition to ...
(Date:2/10/2016)... ... 2016 , ... Emergency rooms provide emergency care to stabilize critical health issues, ... with dental emergencies at risk of losing a tooth or their smiles. Dr. Marine ... Common dental emergencies include:, , Avulsed or knocked-out teeth , ...
(Date:2/10/2016)... ... February 10, 2016 , ... Dr. Peyman ... is now offering a variety of comprehensive procedures for facial enhancement. The treatments ... volume restoration, lip enhancement and nasal reshaping. , As a result, patients ...
(Date:2/10/2016)... ... February 10, 2016 , ... Ongoing news of the ravages of traumatic ... to conduct a survey that takes a closer look at cases of TBI being ... and causes of TBI among the aging population, and identifies the challenges associated with ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... REDWOOD CITY, Calif., Feb. 10, 2016   Genomic Health, Inc. ... progress for the quarter and year ended December 31, 2015. ... in the fourth quarter of 2015, compared with $69.1 million in ... a constant currency basis, revenue increased 9 percent compared with the ... --> U.S. revenue was $63.9 million in the fourth ...
(Date:2/10/2016)... --> --> This press release is intended for U.S. and EU ... .  --> A separate press release has been prepared for use in ... continues to strengthen its presence in Japan ... strengthen its presence in Japan   ... strengthen its presence in Japan   ...
(Date:2/10/2016)... DIEGO , Feb. 10, 2016 ... gene therapy manufacturing, and Renova™ Therapeutics, a biopharmaceutical company ... other chronic diseases, have entered into a Manufacturing Services ... cGMP-grade RT-100 (Ad5.hAC6) Drug Product for use in Renova,s ... --> This relationship will leverage Lonza,s expertise ...
Breaking Medicine Technology: