Navigation Links
Embryonic Pathways Induce Stem Cell Traits
Date:5/15/2008

Regenerative ability holds promise for development of target-specific cancer drugs

THURSDAY, May 15 (HealthDay News) -- Scientists have found that normal cells and cancer cells that acquire the ability to use long dormant pathways to migrate through the body may gain properties of adult stem cells, including the ability to self-renew.

The finding helps researchers better understand adult stem cell creation -- knowledge they hope will lead to developing healthy stem cells for regenerative medicine and target-specific cancer drugs.

Research published online May 15 in Cell shows that cells that undergo an "epithelial-to-mesenchymal" (EMT) transition, in mice or humans, acquire many important stem cell characteristics. The study also shows that normal, naturally existing stem cells and tumor-seeding cancer stem cells share characteristics with these post-EMT cells.

"This for us is a very exciting discovery, not only because of its unexpectedness, but because it offers a route by which one could in principle generate unlimited numbers of stem cells committed to create a specific cell type," researcher Robert Weinberg, a professor of biology at Massachusetts Institute of Technology, said in a prepared statement. "One could imagine, for example, that if one takes skin cells and induces them to undergo an EMT, they could become skin stem cells."

Epithelial cells, which make up most of the human body, bind in sheet-like structures. In embryonic development, the EMT process disrupts this adhesion and changes the cells into more loosely associated mesenchymal cells. In the context of cancer development, some cancer cells within a primary cancer may undergo EMT, migrate through the body to their end destination, and then undergo a reverse conversion back to their original epithelial form.

Inducing the EMT process can produce cells with many characteristics of cancer stem cells, the researchers discovered. This finding could help solve why tumor cells spread into different sites and multiply enough to form a new tumor.

"If you take a population of human cancer cells that normally form a tumor very inefficiently and induce an EMT, their tumor-initiating abilities increase by about a hundredfold, so that it takes about 10,000 cells, rather than a million cells, to form a tumor," co-lead author Wenjun Guo, a postdoctoral researcher in Weinberg's lab, said in a prepared statement. "This suggests cancer stem cells are using preexisting normal stem cell machinery to propagate their own self-renewal and therefore their tumor-initiating ability."

More information

The National Institutes of Health has more about stem cells.



-- Kevin McKeever



SOURCE: Massachusetts Institute of Technology, news release, May 15, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Embryonic Stem Cells Repair Human Heart
2. Embryonic Human Stem Cells May Help Repair Heart Muscle, Lab Study Shows
3. Embryonic stem cells used to grow cartilage
4. Embryonic stem cells thrive when shaken
5. Stem cells in adult testes provide alternative to embryonic stem cells for organ regeneration
6. Study Probes Difference Between Embryonic, Adult Stem Cells
7. Serum carcinoembryonic antigen level can reflect adrenal adenoma
8. UC Davis researchers find evidence of mature heart cell potential in embryonic stem cells
9. Human embryonic stem cell lines created that avoid immune rejection
10. Embryonic Stem Cells Create Healthy Muscle in Mice
11. Scientists Reprogram Human Skin Cells Into Embryonic Stem Cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... The International Association ... standards of excellence for the field of eating disorders, announces the opening of ... 2018 in Orlando, Florida at the Omni Resort at ChampionsGate. , ...
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton Lakes , which ... evacuation of the facility as part of a disaster drill on October 3rd. , ... and Shelton City Emergency Manager, as well as the Connecticut Long Term Care ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids ... Milford, NJ. This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, ... run is geared towards children of all ages; it is a non-competitive, non-timed event, ...
(Date:10/13/2017)... ... 2017 , ... “The Journey: From the Mountains to the Mission Field”: the ... in the Philippines. “The Journey: From the Mountains to the Mission Field” is the ... She has taught all ages and currently teaches a class of ladies at her ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and fastest ... to open a flagship location in Covington, LA at 401 N. U.S. Highway 190, ... next to Office Depot in the Holiday Square shopping center. Its location allows it ...
Breaking Medicine News(10 mins):
(Date:10/7/2017)... --  Provista, a proven leader in the supply ... power, today announced a new resource area on Provistaco.com ... is the online home for case studies, articles on ... releases, slideshows and events. ... at their fingertips, viewers can also watch short videos ...
(Date:10/4/2017)... to the Centers for Disease Control and Prevention (CDC), influenza vaccination ... is helping communities across Massachusetts , Connecticut ... flu shots through the end of the month. *Some exclusions ... ... shot is by the end of October, according to the Centers for ...
(Date:10/2/2017)... , Oct. 2, 2017  Eli Lilly and ... financial results for the third quarter of 2017 on ... conference call on that day with the investment community ... The conference call will begin at 9 ... can access a live webcast of the conference call ...
Breaking Medicine Technology: