Navigation Links
Embryonic Human Stem Cells May Help Repair Heart Muscle, Lab Study Shows

Problems with cell survival, functioning may have been solved in rat experiments

MONDAY, Aug. 27 (HealthDay News) -- Experiments in rats show that human embryonic stem cells can repair damaged heart muscle, improve heart function and slow the progression of heart failure.

Using stem cells to repair damaged hearts is something that appears promising, but so far it has been fraught with problems.

Previous experiments have shown that it is possible to create heart cells from embryonic stem cells. However, most of these cells do not become heart muscle cells, and many don't survive once transplanted into a damaged heart.

"We found a way to increase the survival of these cells," said lead researcher Dr. Charles Murry, director of the Center for Cardiovascular Biology and Regenerative Medicine at the University of Washington, in Seattle.

Murry's team created a "survival" cocktail that prevented the cells from dying. The treated cells were then implanted in rats that had had their hearts damaged to simulate a heart attack.

"If we prepared our cells in this cocktail and transplanted them, we could get virtually 100 percent of the rats to have human heart muscle grafts in them," Murry said.

The researchers compared the rats receiving the cells with three other groups of rats. One group received only injections of water, and another group was given the survival cocktail without cells. The third group was given non-cardiac cells.

The researchers found that the rats that didn't receive the human heart cells all developed heart failure, according to the report in the Aug. 27 online issue of Nature Biotechnology.

"In contrast, the animals that got the human heart muscle grafts implanted in them had a complete reversal of the progression of heart failure," Murry said.

The study shows that growing heart muscle in an injured heart is possible, Murry noted. "In patients who had suffered a heart attack, if we were able to re-muscularize their heart with stem cell-derived heart muscle cells, this should prevent them from developing heart failure," he said. "The rub is that the rat is not a person."

Murry thinks that while the finding is promising, it needs to be confirmed in larger animals such as sheep or pigs, because their hearts beat slower. Rat hearts beat 450 times a minute, while the human heart beats about 70 times a minute. "So, there may be problems that were not predicted with the rat model," he acknowledged.

One expert thinks that while the results of this study are promising, there are still many problems to be overcome before stem cells can be used to treat humans after a heart attack.

"This study makes the case that you can use embryonic stem cells after a heart attack, and shows that there is an improvement in cardiac function," said Dr. Kenneth R. Chien, a member of the Harvard Stem Cell Institute.

In contrast to adult stem cells, these embryonic heart cells appear to actually be heart muscle. Experiments with adult stem cells seem to show improved heart function by creating blood vessels, Chien explained.

Chien noted that long-term follow-up is needed to be sure the heart muscle continues to function and that some of these cells don't become cancer cells, as has been the case with adult stem cells.

"The other issue is whether these cells will survive over a long time and how efficiently are they grafted in with the neighboring cells," Chien said. "In addition, because rat hearts beat so fast, they are resistant to arrhythmias. When you put this into an animal with a slower heart rate, would there be arrhythmias over the long term?"

"Clinical applications are many years away," Chien said. "But this is an important step."

More information

For more information on stem cells and heart attack, visit the U.S. National Institutes of Health.

SOURCES: Charles Murry, M.D., Ph.D., director, Center for Cardiovascular Biology and Regenerative Medicine, University of Washington, Seattle; Kenneth R. Chien, M.D., Ph.D., professor, cell biology, Harvard Medical School, and member, Harvard Stem Cell Institute, Boston; Aug. 27, 2007, online edition, Nature Biotechnology

Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Embryonic Cells Might Prevent Parkinson’s Disease From Worsenin
2. Embryonic Genetic Testing Is Boosting IVF Pregnancies
3. Sperm stem cells could be an alternative to embryonic stem cells in future
4. T-cells Developed from Human Embryonic Stem Cells
5. Treatment of Spinal Cord Injury with Embryonic Stem Cells
6. Human Embryonic Stem Cells Could Be Later Used In Therapeutic Cloning
7. Researchers Create Genetically-Matched Embryonic Stem Cells for Transplantation
8. Embryonic Selection of Sex can Avoid Conceiving Blind Children
9. Lipid Plays Big Role in Embryonic Development
10. Mice can Produce Embryonic Stem Cells Similar to That of Humans
11. Bush Again Vetoes Embryonic Stem Cell Research Bill
Post Your Comments:
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, P.A. ... The attorneys chosen by their peers for this recognition are considered among the top ... Shareholders received special honors as members of this year’s Legal Elite Hall of Fame: ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is excited ... To Recovery® program to drive cancer patients to and from their cancer treatments. ... highest quality of life and ongoing independence. Getting to and from medical treatments ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are sharpening ... Talker Award, an essay contest in which patients and their families pay tribute to ... at the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute ... Dr. Barry M. Weintraub as a prominent plastic surgeon and the network’s newest ... world, and the most handsome men, look naturally attractive. Plastic surgery should be ...
(Date:6/24/2016)... ... 2016 , ... Strategic Capital Partners, LLC (SCP) in concert ... capital for emerging technology companies. SCP has delivered investment events and professional ... than a million dollars of capital investment for five companies. The ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Roche (SIX: RO, ROG; OTCQX: RHHBY) announced that it ... (procalcitonin) assay as a dedicated testing solution for people ... Roche is the first IVD company in the U.S ... assessment and management. PCT is a sepsis-specific ... blood can aid clinicians in assessing the risk of ...
(Date:6/23/2016)... June 23, 2016 , , ... July 7, 2016 , , , , LOCATION: , , ... , , , EXPERT PANELISTS:  , , , Frost & ... Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar and Unmesh Lal, ... The global pharmaceutical industry is witnessing an exceptional era. Several new ...
(Date:6/23/2016)... , June 23, 2016 The vast ... an outpatient dialysis facility.  Treatments are usually 3 times ... hours per visit, including travel time, equipment preparation and ... patient, but especially grueling for patients who are elderly ... a skilled nursing and rehabilitation centers for some duration ...
Breaking Medicine Technology: