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Embracing debate on how cancers develop: Without the answer, effective therapies remain elusive
Date:1/16/2013

New Rochelle, NY, January 16, 2013Scientists invariably conduct debates in private about whether a body of scientific work or thought is worthy of presentation to the community. Behind closed doors scientists and editors tussle over when is the right time to publish their work. In a disruptive departure from this norm, Disruptive Science and Technology, a peer-reviewed journal from Mary Ann Liebert, Inc. publishers, has launched a Debate section in which ideas and counterpoints can be debated in public. The Journal seeks not to sway opinions but rather to inform them. It is fitting that the first series of debates is focused on the root cause of cancer.

Most cancer researchers would likely agree that not understanding how cancer develops is a major obstacle in the ongoing "war on cancer." However, in some scientists' minds the mechanism that underlies tumor development is not settled science. Under the Somatic Mutation Theory, cancers arise as a consequence of changes to DNA, while the Tissue Organization Field Theory states that they result from disruptions in normal cell communication needed to correctly form tissues. The initial debate explores these two major theories of cancer development in Disruptive Science and Technology, and the articles are available free on the Journal website at http://www.liebertpub.com/dst.

Stuart Baker, ScD, National Cancer Institute (Bethesda, MD), initiates the debate with the article, "Paradoxes in Carcinogenesis Should Spur New Avenues of Research: An Historical Perspective." Dr. Baker describes "paradigm instability" between the two main explanations of how cancer develops the more the dominant theory is investigated without a conclusive resolution, the more proponents think they are getting closer to understanding and the more others think the evidence is pointing to an alternative theory. Dr. Baker discusses paradoxes experime
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Contact: Sophie Mohin
smophin@liebertpub.com
914-740-2100
Mary Ann Liebert, Inc./Genetic Engineering News
Source:Eurekalert  

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