Navigation Links
Elusive pancreatic progenitor cells found in mice
Date:1/25/2008

January 25, 2008 --New York, NY-- Researchers in Belgium have significantly advanced the discovery of a pancreatic progenitor cell with the capacity to generate new insulin-producing beta cells. If the finding made in mice holds for humans, the newfound progenitor cells may represent an obvious target for therapeutic regeneration of beta cells in diabetes, the researchers report in the Jan. 25 issue of the research journal Cell, a publication of Cell Press. In people with type 1 diabetes, blood sugar rises due to a loss of the insulin-producing pancreatic beta cells. Insulin is a hormone that helps the body use glucose for energy.

One of the most interesting characteristics of these [adult] progenitor cells is that they are almost indistinguishable from embryonic progenitor cells, said Harry Heimberg at the Juvenile Diabetes Research Foundation Center at Vrije Universiteit Brussel in Belgium and the Beta Cell Biology Consortium. In terms of their structure and gene expression, there are no major differences. They look and behave just like embryonic beta cell progenitors."

We at JDRF believe that this new research provides novel insights that may provide therapeutic potential to regenerate beta cells in type 1 diabetes, said Patricia Kilian, Regeneration Program Director at JDRF.

Previous studies have suggested the existence of a beta cell progenitor in the pancreas after birth, but the identification and characterization of the progenitor cell has not been fully achieved. Other studies showing that replication of adult beta cells can account for beta cell turnover and expansion of beta cells under normal physiologic conditions and called into question the role or existence of a progenitor cell in regeneration. Most people gave up looking because the cells are so few and so hard to activate, added Heimberg.

In the new study, Heimbergs team tied off a duct that drains digestive enzymes from the pancreas, a manipulation that led to a doubling of beta cell mass in the injured part of the pancreas within two weeks. The animals pancreases also began producing more insulin, evidence that the new beta cells were fully functional. Using a genetic labeling technique, the researchers found that the new beta cells were derived from precursor cells that expressed a gene expressed in embryonic progenitor cells called Neurogenin 3 (Ngn3) and that production of the new beta cells depended on activity of this gene. He suspects the regenerative process is sparked by an inflammatory response in the enzyme-flooded pancreas.

The most important challenge now is to extrapolate our findings to patients with diabetes, Heimberg reported. Although he cautioned that any potential diabetes treatment remains in the future, he said our findings reveal the significance of investigating the feasibility of both isolating facultative beta cell progenitors and newly formed beta cells from human pancreas in order to expand and differentiate them in vitro and transplant them in diabetic patients and also composing a mix of factors able to activate beta cell progenitors to expand and differentiate in situ in patients with an absolute or relative deficiency in insulin.


'/>"/>

Contact: Susan Sherman
ssherman@jdrf.org
212-479-7510
Juvenile Diabetes Research Foundation International
Source:Eurekalert

Related medicine news :

1. UGA researchers 1 step closer to elusive cancer vaccine
2. Cancer stem cell subpopulation drives metastasis of human pancreatic cancer
3. Chemotherapy with gemcitabine delays progression of operable pancreatic cancer
4. Jefferson scientists find protein may be key in developing deadly form of pancreatic cancer
5. Protein Gives Clues to Pancreatic Cancer
6. The most important candidate genes for pancreatic stone formation
7. Jefferson scientists find protein helps pancreatic cancer cells evade immune system and spread
8. Imaging neural progenitor cells in the living human brain
9. Tumors use enzyme to recruit regulatory T-cells and suppress immune response
10. Brain cells work differently than previously thought
11. Embryonic Stem Cells Repair Human Heart
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/20/2017)... ... February 20, 2017 , ... Today, Illuma ... plan partners, announced during the 2017 Annual HIMSS Conference & Exhibition ... for diabetic patients and integrating eye care into mainstream healthcare delivery is powered ...
(Date:2/19/2017)... ... February 19, 2017 , ... The Citadel’s new Swain Department ... being led by Amelia Joseph, Ph.D. Joseph was engaged by the college as a ... department in early 2016. After a nation-wide search, she was selected to head the ...
(Date:2/19/2017)... ... February 19, 2017 , ... ProBrand Glitch is a set of 30 glitch distortion logo reveals ... easily reveal any logo with a glitch reveal in just a few clicks of a ... and animation of each preset. Use these presets to add a uniquely animated logo to ...
(Date:2/19/2017)... ... February 19, 2017 , ... Orbita, ... join forces with Healthwise ® at HIMSS 2017 to showcase ... in evidence-based health education, technology and services, will demonstrate a voice-powered knowedge assistant ...
(Date:2/18/2017)... ... February 17, 2017 , ... Focused start-ups, not traditional health ... according to the recent NEJM Catalyst Insights Report on the New Marketplace. ... Insights Council, a qualified group of U.S. executives, clinical leaders, and clinicians at ...
Breaking Medicine News(10 mins):
(Date:2/20/2017)... 20, 2017  Today from HIMSS17, Ambra Health ... suite, announced the launch of  Ambra for Developers ... Built around modern, RESTful web-services, this is the first ... With these new APIs, IT departments at health ... data into other applications such as population health or ...
(Date:2/20/2017)... Research and Markets has announced the addition ... and Trends - Product (RFID refrigerators and RFID freezers), Application (Diagnostic ... to their offering. ... The Global RFID Blood Refrigerator and Freezer Market is poised ... 2025. This industry report analyzes the global markets ...
(Date:2/20/2017)... PUNE, India , February 20, 2017 According ... Formulation (Type (Solution, Suspension, Dry powder), Device Type (Metered dose, Dry Powder, ... to 2021" published by MarketsandMarkets, The market is projected to reach USD ... CAGR of 6.5% during the forecast period. ... ...
Breaking Medicine Technology: