Navigation Links
Elusive pancreatic progenitor cells found in mice
Date:1/25/2008

January 25, 2008 --New York, NY-- Researchers in Belgium have significantly advanced the discovery of a pancreatic progenitor cell with the capacity to generate new insulin-producing beta cells. If the finding made in mice holds for humans, the newfound progenitor cells may represent an obvious target for therapeutic regeneration of beta cells in diabetes, the researchers report in the Jan. 25 issue of the research journal Cell, a publication of Cell Press. In people with type 1 diabetes, blood sugar rises due to a loss of the insulin-producing pancreatic beta cells. Insulin is a hormone that helps the body use glucose for energy.

One of the most interesting characteristics of these [adult] progenitor cells is that they are almost indistinguishable from embryonic progenitor cells, said Harry Heimberg at the Juvenile Diabetes Research Foundation Center at Vrije Universiteit Brussel in Belgium and the Beta Cell Biology Consortium. In terms of their structure and gene expression, there are no major differences. They look and behave just like embryonic beta cell progenitors."

We at JDRF believe that this new research provides novel insights that may provide therapeutic potential to regenerate beta cells in type 1 diabetes, said Patricia Kilian, Regeneration Program Director at JDRF.

Previous studies have suggested the existence of a beta cell progenitor in the pancreas after birth, but the identification and characterization of the progenitor cell has not been fully achieved. Other studies showing that replication of adult beta cells can account for beta cell turnover and expansion of beta cells under normal physiologic conditions and called into question the role or existence of a progenitor cell in regeneration. Most people gave up looking because the cells are so few and so hard to activate, added Heimberg.

In the new study, Heimbergs team tied off a duct that drains digestive enzymes from the pancreas, a manipulation that led to a doubling of beta cell mass in the injured part of the pancreas within two weeks. The animals pancreases also began producing more insulin, evidence that the new beta cells were fully functional. Using a genetic labeling technique, the researchers found that the new beta cells were derived from precursor cells that expressed a gene expressed in embryonic progenitor cells called Neurogenin 3 (Ngn3) and that production of the new beta cells depended on activity of this gene. He suspects the regenerative process is sparked by an inflammatory response in the enzyme-flooded pancreas.

The most important challenge now is to extrapolate our findings to patients with diabetes, Heimberg reported. Although he cautioned that any potential diabetes treatment remains in the future, he said our findings reveal the significance of investigating the feasibility of both isolating facultative beta cell progenitors and newly formed beta cells from human pancreas in order to expand and differentiate them in vitro and transplant them in diabetic patients and also composing a mix of factors able to activate beta cell progenitors to expand and differentiate in situ in patients with an absolute or relative deficiency in insulin.


'/>"/>

Contact: Susan Sherman
ssherman@jdrf.org
212-479-7510
Juvenile Diabetes Research Foundation International
Source:Eurekalert

Related medicine news :

1. UGA researchers 1 step closer to elusive cancer vaccine
2. Cancer stem cell subpopulation drives metastasis of human pancreatic cancer
3. Chemotherapy with gemcitabine delays progression of operable pancreatic cancer
4. Jefferson scientists find protein may be key in developing deadly form of pancreatic cancer
5. Protein Gives Clues to Pancreatic Cancer
6. The most important candidate genes for pancreatic stone formation
7. Jefferson scientists find protein helps pancreatic cancer cells evade immune system and spread
8. Imaging neural progenitor cells in the living human brain
9. Tumors use enzyme to recruit regulatory T-cells and suppress immune response
10. Brain cells work differently than previously thought
11. Embryonic Stem Cells Repair Human Heart
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/17/2017)... ... January 17, 2017 , ... Achieve TMS West, with ... a new office in San Clemente, California this month. Achieve TMS West is ... successfully treating individuals struggling with major depression. Depression impacts over 15 million adults ...
(Date:1/17/2017)... ... January 17, 2017 , ... Surgeons from ... primary eye care practitioners on the latest breakthroughs in the prevention, diagnosis and ... Education Symposium, according to eye surgeon, Jeffrey Martin, MD, FACS, Chief Executive Officer ...
(Date:1/17/2017)... ... January 17, 2017 , ... Wettstein Agencies, ... families and business professionals throughout central Colorado, is joining local nonprofit Aurora Warms ... Aurora Warms The Night organization is committed to breaking the cycle of homelessness ...
(Date:1/17/2017)... ... January 17, 2017 , ... Physicians ... Sandra Lee as keynote speaker for the 34th Annual Miami Breast Cancer Conference®, ... the announcement, PER® president, Phil Talamo, said, “We are delighted to have Sandra ...
(Date:1/17/2017)... ... ... Today, FloSports , a global leader in live digital sports and ... a long-term extension of their media partnership. The partnership, which began in 2013, will ... premier events exclusively on FloWrestling.com as well as usage of the FloArena meet management ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... company that brought a full line of equine first aid kits ... of companion animal pet first aid kits.  EquiMedic USA ... developed two sizes of small pet first aid kits under the ... a small and a large companion pet first aid kit, this ... newcomer to working with small animals either. Corporate owners, mother and ...
(Date:1/17/2017)... ® Technologies, Inc. announces that the Journal ... of Vibration on Molar Distalization," a study that focused ... Bowman , this prospective, peer-reviewed clinical study concluded that ... speeds up molar distalization rates in the apex ... to move the upper molars into a normal, Class ...
(Date:1/17/2017)... -- Research and Markets has announced the addition of ... to their offering. ... The global fluoropolymer market in the healthcare industry to grow ... Global Fluoropolymer Market in the Healthcare Industry 2016-2020, has been ... experts. The report covers the market landscape and its growth prospects ...
Breaking Medicine Technology: