Navigation Links
Elusive pancreatic progenitor cells found in mice
Date:1/25/2008

January 25, 2008 --New York, NY-- Researchers in Belgium have significantly advanced the discovery of a pancreatic progenitor cell with the capacity to generate new insulin-producing beta cells. If the finding made in mice holds for humans, the newfound progenitor cells may represent an obvious target for therapeutic regeneration of beta cells in diabetes, the researchers report in the Jan. 25 issue of the research journal Cell, a publication of Cell Press. In people with type 1 diabetes, blood sugar rises due to a loss of the insulin-producing pancreatic beta cells. Insulin is a hormone that helps the body use glucose for energy.

One of the most interesting characteristics of these [adult] progenitor cells is that they are almost indistinguishable from embryonic progenitor cells, said Harry Heimberg at the Juvenile Diabetes Research Foundation Center at Vrije Universiteit Brussel in Belgium and the Beta Cell Biology Consortium. In terms of their structure and gene expression, there are no major differences. They look and behave just like embryonic beta cell progenitors."

We at JDRF believe that this new research provides novel insights that may provide therapeutic potential to regenerate beta cells in type 1 diabetes, said Patricia Kilian, Regeneration Program Director at JDRF.

Previous studies have suggested the existence of a beta cell progenitor in the pancreas after birth, but the identification and characterization of the progenitor cell has not been fully achieved. Other studies showing that replication of adult beta cells can account for beta cell turnover and expansion of beta cells under normal physiologic conditions and called into question the role or existence of a progenitor cell in regeneration. Most people gave up looking because the cells are so few and so hard to activate, added Heimberg.

In the new study, Heimbergs team tied off a duct that drains digestive enzymes from the pancreas, a manipulation that led to a doubling of beta cell mass in the injured part of the pancreas within two weeks. The animals pancreases also began producing more insulin, evidence that the new beta cells were fully functional. Using a genetic labeling technique, the researchers found that the new beta cells were derived from precursor cells that expressed a gene expressed in embryonic progenitor cells called Neurogenin 3 (Ngn3) and that production of the new beta cells depended on activity of this gene. He suspects the regenerative process is sparked by an inflammatory response in the enzyme-flooded pancreas.

The most important challenge now is to extrapolate our findings to patients with diabetes, Heimberg reported. Although he cautioned that any potential diabetes treatment remains in the future, he said our findings reveal the significance of investigating the feasibility of both isolating facultative beta cell progenitors and newly formed beta cells from human pancreas in order to expand and differentiate them in vitro and transplant them in diabetic patients and also composing a mix of factors able to activate beta cell progenitors to expand and differentiate in situ in patients with an absolute or relative deficiency in insulin.


'/>"/>

Contact: Susan Sherman
ssherman@jdrf.org
212-479-7510
Juvenile Diabetes Research Foundation International
Source:Eurekalert

Related medicine news :

1. UGA researchers 1 step closer to elusive cancer vaccine
2. Cancer stem cell subpopulation drives metastasis of human pancreatic cancer
3. Chemotherapy with gemcitabine delays progression of operable pancreatic cancer
4. Jefferson scientists find protein may be key in developing deadly form of pancreatic cancer
5. Protein Gives Clues to Pancreatic Cancer
6. The most important candidate genes for pancreatic stone formation
7. Jefferson scientists find protein helps pancreatic cancer cells evade immune system and spread
8. Imaging neural progenitor cells in the living human brain
9. Tumors use enzyme to recruit regulatory T-cells and suppress immune response
10. Brain cells work differently than previously thought
11. Embryonic Stem Cells Repair Human Heart
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... 26, 2016 , ... Pixel Film Studios Released ProSlice Levels, a Media Slicing ... their videos a whole new perspective by using the title layers in ProSlice ... , ProSlice Levels contains over 30 Different presets to choose from. FCPX ...
(Date:6/26/2016)... ... June 26, 2016 , ... ... they have been diagnosed with endometriosis. These women need a treatment plan to ... a comprehensive approach that can help for preservation of fertility and ultimately achieving ...
(Date:6/25/2016)... Miami, FL (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton ... Plant City Observer , brings up a new, often overlooked aspect of head lice: ... The closing for fumigation is not a common occurrence, but a necessary one in the ...
(Date:6/25/2016)... ... , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his Bachelors ... Geffen School of Medicine at UCLA. He trained in Internal Medicine at Scripps Green ... hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to train ...
(Date:6/25/2016)... Montreal, Canada (PRWEB) , ... June 25, 2016 , ... ... the pursuit of success. In terms of the latter, setting the bar too high ... low, risk more than just slow progress toward their goal. , Research from ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... June 27, 2016 Jazz Pharmaceuticals plc (Nasdaq: ... under the Hart-Scott-Rodino Antitrust Improvements Act of 1976, as ... Celator Pharmaceuticals, Inc. ("Celator"; Nasdaq: CPXX ) ... Daylight Time). As previously announced on May ... definitive merger agreement under which Jazz Pharmaceuticals has commenced ...
(Date:6/24/2016)... 24, 2016  Global Blood Therapeutics, Inc. (GBT) (NASDAQ: ... novel therapeutics for the treatment of grievous blood-based ... closing of its previously announced underwritten public offering ... public offering price of $18.75 per share. All ... by GBT. GBT estimates net proceeds from the ...
(Date:6/24/2016)... -- Dehaier Medical Systems Ltd. (NASDAQ: DHRM ... sells medical devices and wearable sleep respiratory products in ... agreement with Hongyuan Supply Chain Management Co., Ltd. (hereinafter ... 2016, to develop Dehaier,s new Internet medical technology business. ... leverage Hongyuan Supply Chain,s sales platform to reach Dehaier,s ...
Breaking Medicine Technology: