Navigation Links
Elusive gene mutations found for malignant brain tumor
Date:8/4/2011

DURHAM, N.C. -- A discovery by scientists at Duke University Medical Center and Johns Hopkins University could increase the chances for an effective combination of drug therapy to treat the second most common type of brain tumor.

For years scientists have been looking for the primary cancer genes involved in the development of oligodendrogliomas. Scientists knew the two chromosomes that held the probable mutations, but not the particular gene information.

Now scientists at Duke and Johns Hopkins have discovered the most likely genetic mutations that researchers have been hunting for on chromosomes 1 and 19. These genes were difficult to find until the technology improved, said Hai Yan, M.D., Ph.D., Duke associate professor of pathology and co-corresponding author of the study.

"The team used whole genome sequencing technology so that no genes would be excluded, and we found to our surprise that one gene, on chromosome 19, was mutated in six out of the seven initial tumor specimens we sequenced," Yan said. "A mutation frequency of 85 percent is very high."

The study was published in the Aug. 4 ahead-of-print issue of the journal Science.

"Whenever we find genes mutated in a majority of tumors, it is likely that the pathway regulated by that gene is critical for the development and biology of the tumor," says Nickolas Papadopoulos, Ph.D., co-corresponding author and associate professor of oncology at the Johns Hopkins Kimmel Cancer Center.

The finding of two additional new genes involved in oligodendrogliomas increases the chances for an effective combination drug therapy for the tumor, Yan said. He envisions a combination cocktail of drugs similar to the combination-drug treatments taken by HIV patients that would target different pathways involved in cancer, and assist in reducing the chance of relapsing, increasing odds of success.

The genes they identified are tumor suppressor genes. The cancer-related pathways that involve these genes could become targets for future treatments, Yan said.

"Tumor suppressor genes like the ones we found, CIC or FUBP1, won't be targeted directly by small molecules, because the mutated gene products result in loss of function, but the pathways that these genes are involved in could be targeted," Yan said.

"Another very important feature is that the genes could be used as biomarkers to distinguish this type of cancer from other types of brain tumors."

The researchers found CIC on chromosome 19 and FUBP1 on chromosome 1 based on an initial study of seven oligodendrogliomas; they found six mutations and two mutations, respectively, in the seven tumors. Further study of 27 more of these tumors showed that there were 12 and three mutations of CIC and FUBP1, respectively. The two genes were rarely mutated in other types of cancers, indicating that they are oligodendroglioma-specific genes.

These tumors also contained a glioma (brain tumor) gene mutation identified earlier by Yan and colleagues, the IDH mutations.


'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

Related medicine news :

1. Brazils health care system vastly expands coverage, but universality, equity remain elusive
2. New Research Uncovers Elusive Target of Antifungal Agent
3. Scientists identify order of mutations that lead to cancer
4. Sequence of ovarian genome identifies predominant gene mutations, points to possible treatment
5. P7 protein resistance mutations identified; represent drug targets for hepatitis C virus
6. Study identifies genetic mutations associated with cancer risk for hereditary cancer syndrome
7. Matching targeted therapies to tumors specific gene mutations key to personalized cancer treatment
8. Tracking Swine Flu Virus in Pigs Reveals Mutations
9. Sporadic mutations identified in children with autism spectrum disorders
10. Scientists Spot Key Gene Mutations in Melanoma
11. Ovarian Cancer Prognosis May Depend on Gene Mutations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... , ... June 25, 2016 , ... Conventional wisdom preaches ... success. In terms of the latter, setting the bar too high can result in ... than just slow progress toward their goal. , Research from PsychTests.com ...
(Date:6/24/2016)... ... ... was in a crisis. Her son James, eight, was out of control. Prone to extreme ... “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If there was ... other children and say he was going to kill them. If we were driving ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is excited ... To Recovery® program to drive cancer patients to and from their cancer treatments. ... highest quality of life and ongoing independence. Getting to and from medical treatments ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute ... Dr. Barry M. Weintraub as a prominent plastic surgeon and the network’s newest ... world, and the most handsome men, look naturally attractive. Plastic surgery should be ...
(Date:6/24/2016)... ... June 24, 2016 , ... Venture Construction Group (VCG) ... held on June 20th at the Woodmont Country Club at 1201 Rockville Pike, Rockville, ... dedicated to helping service members that have been wounded in battle and their families. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 2016 Dehaier Medical Systems Ltd. (NASDAQ: ... markets and sells medical devices and wearable sleep respiratory ... strategic cooperation agreement with Hongyuan Supply Chain Management Co., ... June 20, 2016, to develop Dehaier,s new Internet medical ... Dehaier will leverage Hongyuan Supply Chain,s sales platform to ...
(Date:6/24/2016)... , June 24, 2016 ... Market by Type (Standard Pen Needles, Safety Pen Needles), ... (Insulin, GLP-1, Growth Hormone), Mode of Purchase (Retail, Non-Retail) ... MarketsandMarkets, This report studies the market for the forecast ... to reach USD 2.81 Billion by 2021 from USD ...
(Date:6/24/2016)...  Arkis BioSciences, a leading innovator in the ... cerebrospinal fluid treatments, today announced it has secured ... led by Innova Memphis, followed by Angel Capital ... Arkis, new financing will accelerate the commercialization of ... of its in-licensed Endexo® technology. ...
Breaking Medicine Technology: