Navigation Links
Elusive gene mutations found for malignant brain tumor
Date:8/4/2011

DURHAM, N.C. -- A discovery by scientists at Duke University Medical Center and Johns Hopkins University could increase the chances for an effective combination of drug therapy to treat the second most common type of brain tumor.

For years scientists have been looking for the primary cancer genes involved in the development of oligodendrogliomas. Scientists knew the two chromosomes that held the probable mutations, but not the particular gene information.

Now scientists at Duke and Johns Hopkins have discovered the most likely genetic mutations that researchers have been hunting for on chromosomes 1 and 19. These genes were difficult to find until the technology improved, said Hai Yan, M.D., Ph.D., Duke associate professor of pathology and co-corresponding author of the study.

"The team used whole genome sequencing technology so that no genes would be excluded, and we found to our surprise that one gene, on chromosome 19, was mutated in six out of the seven initial tumor specimens we sequenced," Yan said. "A mutation frequency of 85 percent is very high."

The study was published in the Aug. 4 ahead-of-print issue of the journal Science.

"Whenever we find genes mutated in a majority of tumors, it is likely that the pathway regulated by that gene is critical for the development and biology of the tumor," says Nickolas Papadopoulos, Ph.D., co-corresponding author and associate professor of oncology at the Johns Hopkins Kimmel Cancer Center.

The finding of two additional new genes involved in oligodendrogliomas increases the chances for an effective combination drug therapy for the tumor, Yan said. He envisions a combination cocktail of drugs similar to the combination-drug treatments taken by HIV patients that would target different pathways involved in cancer, and assist in reducing the chance of relapsing, increasing odds of success.

The genes they identified are tumor suppressor genes. The c
'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Brazils health care system vastly expands coverage, but universality, equity remain elusive
2. New Research Uncovers Elusive Target of Antifungal Agent
3. Scientists identify order of mutations that lead to cancer
4. Sequence of ovarian genome identifies predominant gene mutations, points to possible treatment
5. P7 protein resistance mutations identified; represent drug targets for hepatitis C virus
6. Study identifies genetic mutations associated with cancer risk for hereditary cancer syndrome
7. Matching targeted therapies to tumors specific gene mutations key to personalized cancer treatment
8. Tracking Swine Flu Virus in Pigs Reveals Mutations
9. Sporadic mutations identified in children with autism spectrum disorders
10. Scientists Spot Key Gene Mutations in Melanoma
11. Ovarian Cancer Prognosis May Depend on Gene Mutations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... Washington, D.C. (PRWEB) October 22, 2014 With ... November, a national survey by the American Institutes for Research ... they know how to use health insurance, but 42 percent ... review a plan’s details before signing up for coverage. , ... literacy, with only 20 percent able to calculate correctly how ...
(Date:10/22/2014)... 22, 2014 Losing Weight Your Body’s Way ... staring you in the face, it certainly can be difficult ... your body an extra favor by doing it the healthy ... diets. Instead, listen to your body, exercise regularly, and choose ... essential to losing weight; you need to exercise more and ...
(Date:10/22/2014)... WALTHAM, MA (PRWEB) October 22, 2014 ... developing new solutions for the treatment of bacterial infections, ... J. Sinskey has joined its board of directors. ... Microbiology and Engineering Systems at The Massachusetts Institute of ... the MIT faculty since 1968. Dr. Sinskey also holds ...
(Date:10/22/2014)... Tara Haelle HealthDay Reporter ... drinking among young adult men may lead to increased blood ... didn,t cause a similar rise in blood pressure for young ... fact, when young adult women drank lightly or moderately, their ... study found. "This finding parallels studies in older adult ...
(Date:10/22/2014)... HealthDay Reporter TUESDAY, Oct. 21, 2014 (HealthDay News) -- ... NBC News in Liberia has cleared the virus from ... Medical Center in Omaha, where he had been treated for the ... confirmed by the U.S. Centers for Disease Control and Prevention found ... NBC News reported Tuesday night. "Recovering from Ebola is ...
Breaking Medicine News(10 mins):Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 2Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 3Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 4Health News:ReductionGuruMD Presents Ways to Improve Your Weight Loss Results 2Health News:Akeso Biomedical Appoints Dr. Anthony J. Sinskey to Board of Directors 2Health News:Binge Drinking May Boost Blood Pressure in Young Men 2Health News:Binge Drinking May Boost Blood Pressure in Young Men 3Health News:Binge Drinking May Boost Blood Pressure in Young Men 4Health News:U.S. Cameraman Treated for Ebola 'Free' of the Virus 2Health News:U.S. Cameraman Treated for Ebola 'Free' of the Virus 3
... low oxygen, study suggests, , TUESDAY, Feb. 2 (HealthDay News) ... crucial to sudden infant death syndrome (SIDS), new research finds. ... of serotonin -- an important regulator of involuntary functions such ... died of other causes, the study found. This finding may ...
... Feb. 2 The National Committee for Quality Assurance (NCQA) ... of Ohio , the first health plan in Ohio ... , Medical Mutual,s wellness program is one of only 15 in ... , WHP is a comprehensive assessment of key areas of health ...
... over possible link between MMR vaccine, developmental disorder ... British medical journal The Lancet on Tuesday ... the measles, mumps and rubella vaccine to autism and ... Feb. 28, 1998, set off a worldwide furor, with ...
... (fictitious name) was born in Bangladesh yet raised in Montreal. At ... pretext of visiting her sick grandmother. The young woman was then ... resistance. The girl later wrote to her mother that she ... raped. After two months, her mother granted her return to Montreal. ...
... ... ... 22, 2010 -- Professional athletes, everyday athletes and even the occasional weekend warriors ... isn’t new technology – it’s been widely used and popular among European athletes ...
... parents over possible link between MMR vaccine, developmental disorder ... prestigious British medical journal The Lancet on ... linked the measles, mumps and rubella vaccine to autism ... Feb. 28, 1998, set off a worldwide furor, ...
Cached Medicine News:Health News:Serotonin May Be Key to Sudden Infant Deaths 2Health News:Serotonin May Be Key to Sudden Infant Deaths 3Health News:Medical Mutual is the First Ohio Health Plan to Receive NCQA Wellness & Health Accreditation 2Health News:Controversial Autism Study Retracted by Medical Journal 2Health News:Controversial Autism Study Retracted by Medical Journal 3Health News:Controversial Autism Study Retracted by Medical Journal 4Health News:From Quebec to France: forced marriages still exist 2Health News:Electrical Muscle Stimulation Proven to Enhance Muscle Development and Sports Performance 2Health News:Electrical Muscle Stimulation Proven to Enhance Muscle Development and Sports Performance 3Health News:Electrical Muscle Stimulation Proven to Enhance Muscle Development and Sports Performance 4Health News:Flawed Autism Study Retracted by Medical Journal 2Health News:Flawed Autism Study Retracted by Medical Journal 3
(Date:10/22/2014)... 21, 2014 Abaxis, Inc. (NasdaqGS: ... analysis systems, today reported financial results for the second ... quarter overview: , Revenues of $53.9 million, up ... EPS of $0.24, up 33% over last year,s comparable ... from Abaxis Veterinary Reference Laboratories (AVRL) of $3.5 million, ...
(Date:10/22/2014)... , Oct. 22, 2014 Sanomedics International Holdings, ... report by Global Research & Data Services, demand for ... from 2014 through 2018, as demand for more accurate ... is the world,s largest market for thermometers, and ... thermometers is Sanomedics International Holdings, Inc. Sanomedics ...
(Date:10/22/2014)... REDWOOD CITY, Calif. , Oct. 22, 2014 ... ) today announced that results from the  IAP310 ... and Pain Medicine (RAPM), a peer-reviewed journal ... placebo-controlled, Phase 3 trial evaluating the safety and ... sufentanil sublingual tablet system (SSTS), for the treatment ...
Breaking Medicine Technology:Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 2Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 3Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 4Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 5Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 6Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 7Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 8Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 9Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 10Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 11Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 12Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 13Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 14Sanomedics International Holdings Analyst Report: Taking Some Heat by BrokerBank Securities, Inc. 2AcelRx Announces Publication of Zalviso Phase 3 Abdominal Trial Results 2
... WASHINGTON, Feb. 9, 2012   The Pharmaceutical Care ... in Pennsylvania that highlights the core value proposition of pharmacy ... What PBMs Do" – focuses on key themes ... and consumers. , PBM mail-service pharmacies improve safety, savings, ...
... Feb. 9, 2012  As part of its ongoing restructuring ... of its subsidiaries as wholly owned subsidiaries of iMD ... time, a wholly owned subsidiary of Optimum Mobile Imaging ... Hyper-Interactive Marketing LLC, will now reside alongside the newly ...
Cached Medicine Technology:PCMA Launches New Pennsylvania Ad Campaign: 'That's What PBMs Do' 2Optimum Mobile Imaging Corp. (ICBU) Retains Securities Law Firm 2
... SPECIFICATIONS Appearance/Form: White to buff-colored powder Activity: >=590g of ... (A&B): Passes tests Limit of Methanol: Specific Rotation ... pH (4%, H 2 O): 3.5 to 5.5 Loss ... C 1 : 25-50% C 2 + C ...
Gentamicin is a selection antibiotic used for selection of a Bac-to-Bac recombinant expression bacmid following transposition. Gentamicin is provided as a solution at a concentration of 50 mg/ml....
Gentamicin is an aminoglycosidic antibiotic that inhibits bacterial growth by inhibiting protein synthesis. Gentamicin is used for prevention and elimination of bacterial contaminants in cell culture...
1.0% Tryptone, 0.5% yeast extract, 0.5% Sodium Chloride, 0.6% agarose....
Medicine Products: